Phomopsols A and B from the Mangrove Endophytic Fungus Phomopsis sp. xy21: Structures, Neuroprotective Effects, and Biogenetic Relationships

  • Org Lett. 2019 Oct 4;21(19):7919-7922. doi: 10.1021/acs.orglett.9b02906.
Wan-Shan Li  1 ,  Han-Bo Hu  2 ,  Zhong-Hui Huang  1 ,  Ren-Jie Yan  1 ,  Li-Wen Tian  1 ,  Jun Wu  1
Affiliations
  • 1. School of Pharmaceutical Sciences , Southern Medical University , 1838 Guangzhou Avenue North , Guangzhou 510515 , P. R. China.
  • 2. Marine Drugs Research Center, College of Pharmacy , Jinan University , 601 Huangpu Avenue West , Guangzhou 510632 , P. R. China.
PMID: 31525876 DOI: 10.1021/acs.orglett.9b02906
Abstract

A polyketide-derived alkaloid featuring a unique 3,4-dihydro-2H-indeno[1,2-b]pyridine 1-oxide motif, named phomopsol A (1), and a highly oxidized polyketide containing a new 3,5-dihydro-2H-2,5-methanobenzo[e][1,4]dioxepine moiety, named phomopsol B (2), were isolated from the Thai mangrove endophytic fungus Phomopsis sp. xy21, together with the related biosynthetic polyketide 3. The structures of 1-3 were unambiguously established by single-crystal X-ray diffraction analysis (Cu Kα), and their neuroprotective effects in PC12 cells were evaluated. The biosynthetic origins of 1-3 are proposed.

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