Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors

  • Curr Top Med Chem. 2020;20(10):815-834. doi: 10.2174/1568026620666200303123102.
Dima A Sabbah  1 ,  Rima Hajjo  1 ,  Kamal Sweidan  2
Affiliations
  • 1. Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, P.O. Box 130, Amman 11733, Jordan.
  • 2. Department of Chemistry, The University of Jordan, Amman 11942, Jordan.
PMID: 32124699 DOI: 10.2174/1568026620666200303123102
Abstract

The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and Cancer development. In this review, the EGFR structure and its mutations, signaling pathway, ligand binding and EGFR dimerization, EGF/EGFR interaction, and the progress in the development of EGFR inhibitors have been explored.

Keywords
EGF; EGFR; ERBB-1; HER-1; Inhibitors; TGF-α; Tyrosine kinase; cancer; mAbs..