Structural elucidation and α‑glucosidase inhibitory activity of a new xanthone glycoside from Lomatogonium rotatum (L.) Fries es Nym

  • Nat Prod Res. 2022 Sep;36(17):4317-4321. doi: 10.1080/14786419.2021.1995864.
Meili Wang  1 ,  Guojun Zhang  1 ,  Nabuqi Bao  1 ,  Aorigele Chen  1 ,  Suya Bai  1 ,  Qinghu Wang  1
Affiliations
  • 1. College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao, China.
PMID: 34727813 DOI: 10.1080/14786419.2021.1995864
Abstract

A new xanthone glycoside, 1,8-dihydroxyl-2,5-dimethoxy-xanthone-6-O-β-D-glucoside (1), along with two known xanthone glycosides and two flavonoid glycosides were isolated from the aerial parts of Lomatogonium rotatum (L.) Fries es Nym. The structure of 1 was elucidated by analysis of its spectroscopic data, including UV, IR, HR-ESI-MS and extensive 1 D and 2 D NMR techniques. In vitro test, compound 1 behaved similarity to swertianolin against α‑glucosidase and more potent inhibitory effects than the positive control, acarbose.

Keywords
Lomatogonium rotatum; Spectroscopic method; Xanthone glycoside; α‑glucosidase inhibitory activity.
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