Luteolin Attenuates Oxidative Stress and Colonic Hypermobility in Water Avoidance Stress Rats by Activating the Nrf2 Signaling Pathway

  • Mol Nutr Food Res. 2023 Nov 30:e2300126. doi: 10.1002/mnfr.202300126.
Yuan Xia  1  2 ,  Wei Tan  1  2 ,  Fangting Yuan  1  2 ,  Mengjuan Lin  1  2 ,  Hesheng Luo  1  2
Affiliations
  • 1. Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
  • 2. Key Laboratory of Hubei Province for Digestive System Diseases, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
PMID: 38037466 DOI: 10.1002/mnfr.202300126
Abstract

Scope: Irritable bowel syndrome (IBS) is an intestinal disorder, whose symptoms can be alleviated by certain dietary phytochemicals. This study explores the role and potential mechanisms of a natural flavonoid luteolin (LUT) in alleviating the excessive motility of colonic smooth muscles and reducing oxidative stress in IBS with diarrhea (IBS-D) rats.

Methods and results: LUT reduces excessive intestinal motility and lowers Reactive Oxygen Species (ROS) levels in a water avoidance stress (WAS) rat model. Moreover, LUT increases the protein expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1), activates the nuclear translocation of Nrf2, and greatly reduces the hydrogen peroxide (H2 O2 )-induced oxidative damage in intestinal epithelial cells.

Conclusions: LUT, a phyto-active component, protects against excessive intestinal motility and diarrhea by regulating the Nrf2 signaling pathway and effectively reduces oxidative stress damage in the colon.

Keywords
Nrf2, oxidative stress; antioxidants, gastrointestinal motility, luteolin.
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