CD8 is down(regulated) for tolerance

  • Trends Immunol. 2024 Jun;45(6):442-453. doi: 10.1016/j.it.2024.04.012.
Noé Rodríguez-Rodríguez  1 ,  Florencia Rosetti  2 ,  José C Crispín  3
Affiliations
  • 1. Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.
  • 2. Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  • 3. Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Monterrey, Mexico. Electronic address: [email protected].
PMID: 38782625 DOI: 10.1016/j.it.2024.04.012
Abstract

Activated CD8+ T cells directly kill target cells. Therefore, the regulation of their function is central to avoiding immunopathology. Mechanisms that curb effector functions in CD4+ and CD8+ T cells are mostly shared, yet important differences occur. Here, we focus on the control of CD8+ T cell activity and discuss the importance of a poorly understood aspect of tolerance that directly impairs engagement of target cells: the downregulation of CD8. We contextualize this process and propose that it represents a key element during CD8+ T cell modulation.

Keywords
CD8; double negative T cell; tolerance.