Melatonin Ameliorates Abnormal Sleep-Wake Behavior via Facilitating Lipid Metabolism in a Zebrafish Model of Parkinson's Disease

  • Neurosci Bull. 2024 Sep 16. doi: 10.1007/s12264-024-01299-8.
Meng-Zhu Pang  #  1  2 ,  Han-Xing Li  #  1 ,  Xue-Qin Dai  2 ,  Xiao-Bo Wang  2 ,  Jun-Yi Liu  3 ,  Yun Shen  1 ,  Xing Xu  1 ,  Zhao-Min Zhong  4  5 ,  Han Wang  4  5 ,  Chun-Feng Liu  6  7  8 ,  Fen Wang  9  10
Affiliations
  • 1. Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
  • 2. Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institutes of Neuroscience, Soochow University, Suzhou, 215123, China.
  • 3. Department of Neurology, The Fourth Affiliated Hospital of Soochow University, Suzhou, 215000, China.
  • 4. Center for Circadian Clocks, Soochow University, Suzhou, 215123, China.
  • 5. School of Biology & Basic Medical Sciences, Medical College, Soochow University, Suzhou, 215123, China.
  • 6. Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. [email protected].
  • 7. Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institutes of Neuroscience, Soochow University, Suzhou, 215123, China. [email protected].
  • 8. Department of Neurology, Xiongan Xuanwu Hospital, Xiongan, 071700, China. [email protected].
  • 9. Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. [email protected].
  • 10. Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institutes of Neuroscience, Soochow University, Suzhou, 215123, China. [email protected].
  • # Contributed equally.
PMID: 39283564 DOI: 10.1007/s12264-024-01299-8
Abstract

Sleep-wake disorder is one of the most common nonmotor symptoms of Parkinson's disease (PD). Melatonin has the potential to improve sleep-wake disorder, but its mechanism of action is still unclear. Our data showed that melatonin only improved the motor and sleep-wake behavior of a zebrafish PD model when Melatonin Receptor 1 was present. Thus, we explored the underlying mechanisms by applying a rotenone model. After the PD zebrafish model was induced by 10 nmol/L rotenone, the motor and sleep-wake behavior were assessed. In situ hybridization and real-time quantitative PCR were used to detect the expression of melatonin receptors and lipid-metabolism-related genes. In the PD model, we found abnormal lipid metabolism, which was reversed by melatonin. This may be one of the main pathways for improving PD sleep-wake disorder.

Keywords
Lipid metabolism; Melatonin; Melatonin receptor 1; Parkinson’s disease; Sleep-wake disorder; Zebrafish.
Products