(Hai)long story short: Phages trip the DNA wire-Snap!

  • Mol Cell. 2025 Jul 3;85(13):2460-2461. doi: 10.1016/j.molcel.2025.06.011.
Johannes A Kuehn  1 ,  Rafael Pinilla-Redondo  2
Affiliations
  • 1. Section of Microbiology, University of Copenhagen, Copenhagen, Denmark.
  • 2. Section of Microbiology, University of Copenhagen, Copenhagen, Denmark. Electronic address: [email protected].
PMID: 40614705 DOI: 10.1016/j.molcel.2025.06.011
Abstract

In a recent paper in Nature, Tan et al.1 describe the Bacterial Hailong anti-phage system, in which constitutively synthesized DNA oligonucleotides inhibit a toxic ion channel-a molecular booby trap primed for activation by phage exonucleases.