1. Recombinant Proteins
  2. Receptor Proteins
  3. Pattern Recognition Receptors
  4. C-type Lectin Receptors
  5. C-Type Lectin Domain Family 10 Member A/CD301
  6. CLEC10A/CD301 Protein, Mouse (HEK293, His)

CLEC10A/CD301 Protein, Mouse (HEK293, His)

Cat. No.: HY-P76266
COA Handling Instructions

The CLEC10A/CD301 protein is a receptor that recognizes terminal galactose and N-acetylgalactosamine units and is involved in a variety of biological processes. It may play a crucial role by promoting interactions between tumor-killing macrophages and tumor cells. CLEC10A/CD301 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CLEC10A/CD301 protein, expressed by HEK293 , with C-His labeled tag. The total length of CLEC10A/CD301 Protein, Mouse (HEK293, His) is 248 a.a., with molecular weight of 38-45 KDa.

For research use only. We do not sell to patients.

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50 μg $350 In-stock
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  • Biological Activity

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Description

The CLEC10A/CD301 protein is a receptor that recognizes terminal galactose and N-acetylgalactosamine units and is involved in a variety of biological processes. It may play a crucial role by promoting interactions between tumor-killing macrophages and tumor cells. CLEC10A/CD301 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CLEC10A/CD301 protein, expressed by HEK293 , with C-His labeled tag. The total length of CLEC10A/CD301 Protein, Mouse (HEK293, His) is 248 a.a., with molecular weight of 38-45 KDa.

Background

CLEC10A/CD301 Protein is a receptor that specifically recognizes terminal galactose and N-acetylgalactosamine units, suggesting its involvement in various biological processes. It may play a crucial role in facilitating the interaction between tumoricidal macrophages and tumor cells. Additionally, CLEC10A/CD301 Protein has been implicated in the recruitment of inflammatory monocytes to adipose tissue during diet-induced obesity. It forms homooligomers and interacts with SIGLEC1, potentially acting as a counter-receptor for CLEC10A/CD301 Protein in lymph nodes.

Species

Mouse

Source

HEK293

Tag

C-His

Accession

P49300 (Q57-S304)

Gene ID

17312  [NCBI]

Molecular Construction
N-term
CLEC10A (Q57-S304)
Accession # P49300
His
C-term
Synonyms
C-type lectin domain family 10 member A; CD301; CLEC10A; CLECSF13; CLECSF14; HML
Molecular Weight

38-45 kDa.

Purity

Greater than 95% as determined by Tris-Bis PAGE under reduced condition.

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
CLEC10A/CD301 Protein, Mouse (HEK293, His)
Cat. No.:
HY-P76266
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