CNOT9 Protein, Human (His, Strep)
CNOT9 Protein, Human (His, Strep) is the recombinant human-derived CNOT9, expressed by E. coli , with Strep, His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
CNOT9 Protein, Human (His, Strep) is the recombinant human-derived CNOT9, expressed by E. coli , with Strep, His labeled tag.
Background
CNOT9 is a component of the CCR4-NOT complex, a major cellular mRNA deadenylase involved in processes such as bulk mRNA degradation, miRNA-mediated repression, translational repression during initiation, and general transcription regulation. Its broader functions may stem from modulating mRNA expression. It downregulates MYB- and JUN-dependent transcription (by similarity) and potentially contributes to cell differentiation. In vitro, CNOT9 binds oligonucleotides like poly-G, poly-C, or poly-T, though the physiological relevance remains unclear, and it does not bind poly-A. It enhances ligand-dependent transcriptional activity of nuclear hormone receptors (e.g., RARA) but has minimal or no effect on ESR1-mediated transcription.
Technical Parameters
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Species Human
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Source E. coli
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Tag Strep;His
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Accession
Q92600-1 (M1-Q299)
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Gene ID9125
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Protein Length
Full Length of Isoform-1
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Synonyms
CNOT9; RCD1+; Prev. RQCD1; RCD1 Required For Cell Differentiation1 Homolog (S. Pombe); RCD1; RCD1 Required For Cell Differentiation1 Homolog; Cell Differentiation Protein RQCD1 Homolog; Cell Differentiation Protein RCD1 Homolog; CT129; Protein Involved In
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AA Sequence
MHSLATAAPVPTTLAQVDREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQVLKDDTTTKRWLAQLVKNLQEGQVTDPRGIPLPPQ
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Predicted Molecular Mass
36.8 kDa
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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