2. Recombinant Proteins
  3. Complement System
  4. Complement Regulatory Proteins
  5. Factor D
  6. Complement Factor D/Adipsin Protein, Mouse (HEK293, Fc)

Complement Factor D/Adipsin Protein, Mouse (HEK293, Fc)

Cat. No.: HY-P78273
Handling Instructions

Complement Factor D/Adipsin Protein cleaves factor B in complex with factor C3b, activating the C3bbb complex to form the C3 convertase in the alternate pathway, analogous to C1s in the classical pathway. Complement Factor D/Adipsin Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Complement Factor D/Adipsin Protein, Mouse (HEK293, Fc) is 234 a.a., with molecular weight of 60-70 kDa.

For research use only. We do not sell to patients.

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Description

Complement Factor D/Adipsin Protein cleaves factor B in complex with factor C3b, activating the C3bbb complex to form the C3 convertase in the alternate pathway, analogous to C1s in the classical pathway. Complement Factor D/Adipsin Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Complement Factor D/Adipsin Protein, Mouse (HEK293, Fc) is 234 a.a., with molecular weight of 60-70 kDa.
Background

Complement Factor D/Adipsin Protein functions by cleaving factor B, specifically when it is complexed with factor C3b. This cleavage activates the C3bbb complex, transforming it into the C3 convertase of the alternate pathway. The protein's role is homologous to that of C1s in the classical pathway.
Species

Mouse
Source

HEK293
Tag

C-hFc
Accession

P03953 (I26-S259)
Gene ID

11537  [NCBI]
Molecular Construction
N-term
CFD (I26-S259)
Accession # P03953
hFc
C-term
Synonyms
Adipsin; C3 convertase activator; Complement factor D; CFD; PFD; DF; ADN; FACTOR D; AMBP-1; EC 3.4.21; EC 3.4.21.46
Molecular Weight

60-70 kDa
Purity

Greater than 95% as determined by Tris-Bis PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

Complement Factor D/Adipsin Protein, Mouse (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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