GPR52 Protein, Human (HEK293, Flag, His)
GPR52 Protein, Human (HEK293, Flag, His) is the recombinant human-derived GPR52, expressed by HEK293 , with His, Flag labeled tag. ,
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
GPR52 Protein, Human (HEK293, Flag, His) is the recombinant human-derived GPR52, expressed by HEK293 , with His, Flag labeled tag. ,
Background
GPR52 is a Gs-coupled receptor activated by the antipsychotic drug reserpine, leading to increased intracellular cAMP and its internalization. It may play a role in locomotor activity by modulating dopamine, NMDA, and ADORA2A-induced locomotor responses, with these behavioral changes accompanied by alterations in dopamine receptor signaling pathways in the striatum. Additionally, GPR52 modulates HTT levels via cAMP-dependent but PKA-independent mechanisms by activating RAB39B, which translocates HTT to the endoplasmic reticulum, thereby preventing proteasomal degradation. by similar: These findings suggest GPR52 as a potential therapeutic target in neuropsychiatric disorders.
Technical Parameters
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Species Human
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Source HEK293
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Tag His;Flag
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Accession
Q9Y2T5 (G17-K235, R262-M340, A130W, A264L, W278Q, C314P, S318A, N321D, V323T)
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Gene ID9293
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Protein Length
Partial
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Synonyms
GPR52; G-Protein Coupled Receptor 52; G Protein-Coupled Receptor 52; Probable G-Protein Coupled Receptor 52
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AA Sequence
RYLMVLFRITSVFYMLQLPYIIYFLLESSRVLDNPTLSFLTTWLAISNSFCNPVIYALSDSTFRLGLRRLSETMCTSCM
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Predicted Molecular Mass
65.5 kDa
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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