hflC Protein, E.coli (His)
The hflC protein cooperates with HflK to centrally regulate the stability of the phage lambda cII protein and affect the lysogenization frequency. HflC and HflK cooperate to form HflKC, which inhibits the SecY degradation activity of FtsH and may contribute to overall membrane protein quality control. hflC Protein, E.coli (His) is the recombinant E. coli-derived hflC protein, expressed by E. coli , with N-6*His labeled tag.
- Species: E.coli
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The hflC protein cooperates with HflK to centrally regulate the stability of the phage lambda cII protein and affect the lysogenization frequency. HflC and HflK cooperate to form HflKC, which inhibits the SecY degradation activity of FtsH and may contribute to overall membrane protein quality control. hflC Protein, E.coli (His) is the recombinant E. coli-derived hflC protein, expressed by E. coli , with N-6*His labeled tag.
Background
The hflC Protein, in collaboration with HflK, plays a pivotal role in regulating the stability of the phage lambda cII protein, thereby exerting control over the lysogenization frequency of phage lambda. Beyond its involvement in phage dynamics, HflC, in conjunction with HflK, forms a complex known as HflKC, originally referred to as HflA. This complex interacts with FtsH, inhibiting its SecY-degrading activity and potentially contributing to the quality control of integral membrane proteins. The interaction between HflKC and FtsH is stimulated by ATP, emphasizing the dynamic nature of this regulatory mechanism. Additionally, HflKC engages with YccA, further expanding its network of interactions and underscoring its multifaceted role in cellular processes.
Technical Parameters
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Species E.coli
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Source E. coli
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Tag N-6*His
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Accession
P0ABC4 (M1-R334)
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Gene ID75202409
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Molecular Construction
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N-term
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6*His
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hflC (M1-R334)
Accession # P0ABC4 -
C-term
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Protein Length
Full Length
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Synonyms
Modulator of FtsH protease HflC; hflC; c5259
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AA Sequence
MRKSVIAIIIIVLVVLYMSVFVVKEGERGITLRFGKVLRDDDNKPLVYEPGLHFKIPFIETVKMLDARIQTMDNQADRFVTKEKKDLIVDSYIKWRISDFSRYYLATGGGDISQAEVLLKRKFSDRLRSEIGRLDVKDIVTDSRGRLTLEVRDALNSGSAGTEDEVTTPAADNAIAEAAERVTAETKGKVPVINPNSMAALGIEVVDVRIKQINLPTEVSEAIYNRMRAEREAVARRHRSQGQEEAEKLRATADYEVTRTLAEAERQGRIMRGEGDAEAAKLFADAFSKDPDFYAFIRSLRAYENSFSGNQDVMVMSPDSDFFRYMKTPTSATR
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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