IAPP Protein, Human (GST)
Based on 1 Customer Validation
The IAPP protein selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, affecting glucose metabolism without affecting adipocytes. IAPP interacts with IDE (insulin-degrading enzyme) and insulin (INS) to form homodimers, affecting their fibril formation. IAPP Protein, Human (GST) is the recombinant human-derived IAPP protein, expressed by E. coli , with N-GST labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The IAPP protein selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, affecting glucose metabolism without affecting adipocytes. IAPP interacts with IDE (insulin-degrading enzyme) and insulin (INS) to form homodimers, affecting their fibril formation. IAPP Protein, Human (GST) is the recombinant human-derived IAPP protein, expressed by E. coli , with N-GST labeled tag.
Background
IAPP protein demonstrates selective inhibition of insulin-stimulated glucose utilization and glycogen deposition in muscle, exhibiting a specific impact on muscle glucose metabolism without affecting adipocytes. This protein is known to interact with IDE (insulin-degrading enzyme) and insulin (INS), forming homodimers as part of its functional mechanisms. Notably, the interaction with insulin not only influences the homodimerization of IAPP but also inhibits fibril formation, suggesting a regulatory role in modulating the assembly of fibrillar structures associated with IAPP. These interactions highlight the intricate interplay of IAPP in the regulation of glucose metabolism and its dynamic relationship with key molecular partners.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-GST
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Accession
P10997 (K34-Y70)
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Molecular Construction
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N-term
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GST
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IAPP (K34-Y70)
Accession # P10997 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
IAPP; Diabetes-Associated Peptide; Islet Amyloid Polypeptide; Insulinoma Amyloid Peptide; DAP; Amylin; AMYLIN; Islet Amyloid Polypeptide (Diabetes-Associated Peptide; Amylin); IAP
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AA Sequence
KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY
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Predicted Molecular Mass
31.4 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, 6% trehalose, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
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Data Sheet (232 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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