ICAM-2/CD102 Protein, Mouse (HEK293)
Based on 1 Customer Validation
The ICAM-2/CD102 protein is a key player in cellular interactions, acting as a ligand for the leukocyte adhesion protein LFA-1. It inhibits LFA-1-dependent cell adhesion and contributes to lymphocyte recycling. ICAM-2/CD102 Protein, Mouse (HEK293) is the recombinant mouse-derived ICAM-2/CD102 protein, expressed by HEK293 , with tag free.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The ICAM-2/CD102 protein is a key player in cellular interactions, acting as a ligand for the leukocyte adhesion protein LFA-1. It inhibits LFA-1-dependent cell adhesion and contributes to lymphocyte recycling. ICAM-2/CD102 Protein, Mouse (HEK293) is the recombinant mouse-derived ICAM-2/CD102 protein, expressed by HEK293 , with tag free.
Background
ICAM-2/CD102 protein emerges as a significant participant in cellular interactions, functioning as a ligand for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). Notably, ICAM-2 may contribute to lymphocyte recirculation by inhibiting LFA-1-dependent cell adhesion. Its involvement extends to mediating adhesive interactions crucial for various immune processes, including antigen-specific immune responses, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions vital for immune response and surveillance. The protein further interacts with RDX, EZR, and MSN, emphasizing its intricate associations in the cellular machinery that underlies immune regulation and surveillance.
Verified Bioactivity
Measured by its ability to support the adhesion of PMA-stimulated jurkat cells to plates pre-coated with ICAM-2. Recombinant Mouse ICAM‑2/CD102 immobilized at 12.5 µg/mL (100 µL/well) will induce 66.89% cell adhesion.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag Tag Free
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Accession
P35330 (S20-Q222)
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Molecular Construction
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N-term
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ICAM-2 (S20-Q222)
Accession # P35330 -
C-term
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Protein Length
Extracellular Domain
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Synonyms
ICAM2; Intercellular Adhesion Molecule 2, Isoform CRA_a; Intercellular Adhesion Molecule 2; CD102 Antigen; CD102; ICAM2 Protein; ICAM-2
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AA Sequence
SGEKAFEVYIWSEKQIVEATESWKINCSTNCAAPDMGGLETPTNKIMLEEHPQGKWKQFLVSNVSKDTVFFCHFTCSGKQHSESLNIRVYQPPAQVTLKLQPPRVFVGEDFTIECTVSPVQPLERLTLSLLRGRETLKNQTFGGAETVPQEATATFNSTALKKDGLNFSCQAELDLRPHGGYIIRSISEYQILEVYEPMQDNQ
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Molecular Weight
Approximately 38-42 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (236 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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