MYC Protein, Human (C-His)
Based on 1 publication(s) in Google Scholar
MYC Protein, Human (C-His) is the recombinant human-derived MYC protein, expressed by E. coli, with C-6*His tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
MYC Protein, Human (C-His) is the recombinant human-derived MYC protein, expressed by E. coli, with C-6*His tag.
Background
C-MYC is a transcription factor that binds DNA non-specifically while also recognizing the core sequence 5'-CAC[GA]TG-3'. It activates the transcription of growth-related genes and binds to the VEGFA promoter to promote VEGFA production and sprouting angiogenesis. As a regulator of somatic reprogramming, it controls the self-renewal of embryonic stem cells (by similar). It functions with TAF6L to activate target gene expression through RNA polymerase II pause release (by similar). Additionally, it positively regulates the transcription of HNRNPA1, HNRNPA2, and PTBP1, which modulate the splicing of pyruvate kinase PKM by repressing exon 9 inclusion, leading to exon 10 inclusion and the production of the PKM M2 isoform.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Bioenerg Biomembr
DNMT1 methylates E3 ligase FBXO32 to regulate Myc stability and glycolytic reprogramming in diabetic retinopathy associated endothelial cells. [Abstract]2026 Jun 25;58(1):34. PMID: 42348038
Technical Parameters
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Species Human
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Source E. coli
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Tag C-6*His
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Accession
P01106-1 (M1-A439)
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Gene ID4609
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Molecular Construction
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N-term
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(M1-A439)
Accession # P01106-1 -
6*His
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C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
MYC; V-Myc Myelocytomatosis Viral Oncogene Homolog; MYC Proto-Oncogene, BHLH Transcription Factor; Class E Basic Helix-Loop-Helix Protein 39; BHLHe39; MRTL; Myc Proto-Oncogene Protein; V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian), Isoform CRA_b;
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AA Sequence
MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA
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Predicted Molecular Mass
49.6 kDa
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Molecular Weight
Approximately 58 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder
1.Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.
2.Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 1 mM DTT, 8% trehalose.
Please refer to the lot-specific COA for specific buffer information.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (238 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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