TPH2 Protein, Human (His)

TPH2 Protein, an isozyme of tryptophan hydroxylase, is a member of the pterin-dependent aromatic acid hydroxylase family. TPH2 is selectively expressed only in the serotonergic neurons of the raphe nuclei and is a rate-limiting enzyme in the brain serotonin synthesis pathway. TPH2 plays a more prominent role in the 5-HT synthesis in the brain. Moreover, it is a key factor in maintaining normal serotonin transfer in the central nervous system. TPH2 Protein, Human (His) is the recombinant human-derived TPH2 protein, expressed by E. coli, with N-6*His labeled tag. The total length of TPH2 Protein, Human (His) is 490 a.a., with molecular weight of ~60.0 kDa.

Tryptophan 5-hydroxylase 2 (TPH2), an isozyme of tryptophan hydroxylase, is a member of the pterin-dependent aromatic acid hydroxylase family. TPH2 is selectively expressed only in the serotonergic neurons of the raphe nuclei and is a rate-limiting enzyme in the brain serotonin synthesis pathway. TPH2 plays a more prominent role in the 5-HT synthesis in the brain. 5HT is causally involved in numerous central nervous activities, and it has several functions in peripheral tissues, including the maintenance of vascular tone and gut motility. TPH2 plays a role in anxiety-, aggression- and depression-related personality traits and in the pathogenesis of disorders featuring deficits in cognitive control and emotion regulation. Moreover, it is a key factor in maintaining normal serotonin transfer in the central nervous system. TPH2 isoform is specifically expressed in the brain^[1][2].

Human

E. coli

N-6*His

Q8IWU9 (M1-I490)

121278

MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATESGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI

Approximately 60.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.