VSTM5 Protein, Human (His)
The VSTM5 protein acts as a cell adhesion-like membrane protein in the central nervous system (CNS) and exerts a critical influence on the positioning and complexity of central neurons by regulating their membrane morphology and dynamics. It is actively involved in the formation of neuronal dendrites and protrusions, including dendritic filopodia, contributing to the complex structure of neural networks. VSTM5 Protein, Human (His) is the recombinant human-derived VSTM5 protein, expressed by E. coli , with N-His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The VSTM5 protein acts as a cell adhesion-like membrane protein in the central nervous system (CNS) and exerts a critical influence on the positioning and complexity of central neurons by regulating their membrane morphology and dynamics. It is actively involved in the formation of neuronal dendrites and protrusions, including dendritic filopodia, contributing to the complex structure of neural networks. VSTM5 Protein, Human (His) is the recombinant human-derived VSTM5 protein, expressed by E. coli , with N-His labeled tag.
Background
VSTM5, a cell adhesion-like membrane protein predominantly found in the central nervous system (CNS), exerts a significant impact on the positioning and intricacy of central neurons by modifying their membrane morphology and dynamics. Functionally, VSTM5 is involved in shaping neuronal dendrites and protrusions, including dendritic filopodia, and plays a pivotal role in synaptogenesis by regulating synapse formation through alterations in dendritic spine morphology and actin distribution. Notably, it promotes the formation of unstable neuronal spines, particularly of the thin and branched types. During cortical development in the brain, VSTM5 plays a regulatory role in neuronal morphogenesis and migration. Furthermore, VSTM5 demonstrates the ability to homooligomerize through cis interactions within the same cell membrane.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-His
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Accession
A8MXK1 (L29-H147)
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Gene ID387804 [NCBI]
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Molecular Construction
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N-term
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His
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VSTM5 (L29-H147)
Accession # A8MXK1 -
C-term
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Protein Length
Extracellular Domain
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Synonyms
VSTM5; V-Set And Transmembrane Domain Containing 5; C11orf90; V-Set And Transmembrane Domain-Containing Protein 5; LOC387804; Chromosome 11 Open Reading Frame 90
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AA Sequence
LQSQGVSLYIPQATINATVKEDILLSVEYSCHGVPTIEWTYSSNWGTQKIVEWKPGTQANISQSHKDRVCTFDNGSIQLFSVGVRDSGYYVITVTERLGSSQFGTIVLHVSEILYEDLH
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Predicted Molecular Mass
19.3 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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