VSTM5 Protein, Human (His)

The VSTM5 protein acts as a cell adhesion-like membrane protein in the central nervous system (CNS) and exerts a critical influence on the positioning and complexity of central neurons by regulating their membrane morphology and dynamics. It is actively involved in the formation of neuronal dendrites and protrusions, including dendritic filopodia, contributing to the complex structure of neural networks. VSTM5 Protein, Human (His) is the recombinant human-derived VSTM5 protein, expressed by E. coli , with N-His labeled tag. The total length of VSTM5 Protein, Human (His) is 119 a.a., with molecular weight of ~19.3 kDa.

VSTM5, a cell adhesion-like membrane protein predominantly found in the central nervous system (CNS), exerts a significant impact on the positioning and intricacy of central neurons by modifying their membrane morphology and dynamics. Functionally, VSTM5 is involved in shaping neuronal dendrites and protrusions, including dendritic filopodia, and plays a pivotal role in synaptogenesis by regulating synapse formation through alterations in dendritic spine morphology and actin distribution. Notably, it promotes the formation of unstable neuronal spines, particularly of the thin and branched types. During cortical development in the brain, VSTM5 plays a regulatory role in neuronal morphogenesis and migration. Furthermore, VSTM5 demonstrates the ability to homooligomerize through cis interactions within the same cell membrane.

Human

E. coli

N-His

A8MXK1 (29L-147H)

387804  [NCBI]

LQSQGVSLYIPQATINATVKEDILLSVEYSCHGVPTIEWTYSSNWGTQKIVEWKPGTQANISQSHKDRVCTFDNGSIQLFSVGVRDSGYYVITVTERLGSSQFGTIVLHVSEILYEDLH

Approximately 19.3 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.