1. PI3K/Akt/mTOR
  2. PI3K
  3. (S)-PI3Kα-IN-4

(S)-PI3Kα-IN-4 

Cat. No.: HY-131345A
Handling Instructions

(S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM. (S)-PI3Kα-IN-4 shows 38.3-, 4.25-, and 4.93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (S)-PI3Kα-IN-4 can be used for the research of cancer.

For research use only. We do not sell to patients.

(S)-PI3Kα-IN-4 Chemical Structure

(S)-PI3Kα-IN-4 Chemical Structure

CAS No. : 2322293-84-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 493 In-stock
Estimated Time of Arrival: December 31
5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
10 mg USD 680 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3400 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

(S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM. (S)-PI3Kα-IN-4 shows 38.3-, 4.25-, and 4.93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (S)-PI3Kα-IN-4 can be used for the research of cancer[1].

IC50 & Target[1]

PI3Kα

2.3 nM (IC50)

In Vitro

(S)-PI3Kα-IN-4 (compound 11) is a quinazolin-4(3H)-one derivative with 2-substituted-N-methylpropanamide substitution[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

560.00

Formula

C₂₅H₂₃ClFN₅O₅S

CAS No.

2322293-84-3

SMILES

O=C(NC)[[email protected]@H](C)CN1C=NC2=C(C=C(C3=CC(NS(=O)(C4=CC=C(F)C=C4Cl)=O)=C(OC)N=C3)C=C2)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

(S)-PI3Kα-IN-4PI3KPhosphoinositide 3-kinasePI3KαPI3KβPI3KδPI3KγcancerInhibitorinhibitorinhibit

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(S)-PI3Kα-IN-4
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