country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-182065

Copy Link Print Information

SARS-CoV-2 Mpro-IN-56

SARS-CoV-2 Mpro-IN-56 is an orally active SARS-CoV-2 Mpro inhibitor with an IC₅₀ of 0.026 μM. SARS-CoV-2 Mpro-IN-56 can be used for the research of COVID-19.

For research use only. We do not sell to patients.

Formula: C₃₄H₂₂F₂N₄O₂S₂
Molecular Weight:620.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SARS-CoV-2 Mpro-IN-56 Chemical Structure

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

SARS-CoV-2 Mpro-IN-56 is an orally active SARS-CoV-2 Mpro inhibitor with an IC₅₀ of 0.026 μM. SARS-CoV-2 Mpro-IN-56 can be used for the research of COVID-19^[1].

In Vitro

SARS-CoV-2 Mpro-IN-56 (Compound 35) has a CC₅₀ of 277 μM in HEK-293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SARS-CoV-2 Mpro-IN-56 (50-1500 mg/kg; oral gavage; single dose) has an LD₅₀ of 947.6 mg/kg BW in female Swiss albino mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss female albino mice (25-30 g)^[1]
Dosage:

50, 250, 500, 750, 1000, 1250, 1500 mg/kg BW
Administration:

p.o.; single dose
Result:

Resulted in 100% mortality (3/3 mice) at 1500 mg/kg BW.
Resulted in 80% mortality (4/5 mice) at 1250 mg/kg BW.
Resulted in 57.14% mortality (4/7 mice) at 1000 mg/kg BW.
Resulted in 22.22% mortality (2/9 mice) at 750 mg/kg BW.
Resulted in 0% mortality (9/9 mice per dose) at 500, 250, and 50 mg/kg BW.
Calculated an oral LD₅₀ of 947.6 mg/kg BW (95% CI: 892.3-1003 mg/kg BW; R²=0.9930).
Determined an oral LD₁₀₀ of 1500 mg/kg BW.

Chemical Information

Molecular Weight 620.69
Formula C₃₄H₂₂F₂N₄O₂S₂
SMILES

O=C(NC1=CC=C(SC(N(C/2=O)C(C3=CC=C(F)C(F)=C3)SC2=C/C4=CNC5=C4C=CC=C5)=N6)C6=C1)/C=C/C7=CC=CC=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kanwal S, et al. Electrophilic warhead engagement and structure-activity relationship of Benzothiazole-based putative covalent inhibitors targeting SARS-CoV-2 Main protease. Bioorg Chem. 2026 Jun 5;173:109664. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote