48 Results for "

TNF-R1

" in MedChemExpress (MCE) Product Catalog:
Products (48)

48 Results for "TNF-R1" in MCE Product Catalog:

Cat. No.: HY-P11214
CAS No.: 2243975-43-9
Synonyms: H-TL1
Hydrostatin-TL1 (H-TL1), a nine-amino-acid peptide, is a TNF-α antagonist. Hydrostatin-TL1 can be isolated from the venom gland of sea snake Hydrophis cyanocinctus. H-TL1 competitively inhibits the interaction between TNF-α/TNFR1 and attenuates the cytotoxicity and inflammation of TNF-α. Hydrostatin-TL1 can be used for TNF-α-associated inflammatory diseases, such as rheumatoid arthritis, osteoporosis and inflammatory bowel disease (IBD) research [1].
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Cat. No.: HY-P11108A
RP-182 acetate is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (Kd = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 acetate induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 high TAMs. RP-182 acetate has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 acetate is used in pancreatic cancer and melanoma research [1] .
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Cat. No.: HY-178053
CAS No.: 1191937-43-5
AHR agonist 10 is a potent AHR agonist (EC50 = 2.01 nM). AHR agonist 10 can elevate the transcript levels of key AHR downstream pathway target genes, including CYP1A1 and CYP1B1. AHR agonist 10 can downregulate the expression levels of CD36, IL-18 and shows low cytotoxicity (>40 μM) to normal cells. AHR agonist 10 can suppress the expression of CCL5, CCL20, IL-6, IL-8, S100A9, TLR4, TNF-α, and TNFR1, demonstrating that AHR agonist 10 effectively modulate inflammatory responses through AHR dependent signaling pathways. AHR agonist 10 can be used for psoriasis research [1].
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Cat. No.: HY-B0190B
CAS No.: 80251-32-7
Nafamostat hydrochloride, an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat hydrochloride has anticancer and antivirus effect. Nafamostat hydrochloride induces apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat hydrochloride can be used in the development of the pathological thickening of the arterial wall [1] .
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Cat. No.: HY-133807B
CAS No.: 2637243-08-2
Purity:  99.17%
Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

(R)-Benpyrine is the isomer of Benpyrine (HY-133807), and can be used as an experimental control. Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research [1].
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Cat. No.: HY-RS17435
Research Areas:  

Others

Tnfrsf1b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf1b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS14810
Research Areas:  

Others

TNFRSF1A Human Pre-designed siRNA Set A contains three designed siRNAs for TNFRSF1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-N0481R
CAS No.: 6812-81-3
Roburic acid (Standard) is the analytical standard of Roburic acid. This product is intended for research and analytical applications. Roburic acid acts as an anti-inflammatory, anti-tumor and osteoclastogenesis inhibitor, with a Ki of 7.066 μM against human TNF, an IC50 of 9 μM against human COX-2, and an IC50 of 5 μM against ovine COX-1. Roburic acid reduces the production of inflammatory mediators such as NO and IL-6 in macrophages by inhibiting the NF-κB and MAPK (p38/JNK) pathways. By competitively inhibiting the TNF-TNF-R1 interaction, Roburic acid blocks the downstream NF-κB signaling pathway, thereby inducing cell cycle arrest and apoptosis in cancer cells. Roburic acid specifically inhibits osteoclastogenesis and bone resorption by suppressing the RANKL/TRAF6/NF-κB/NFATc1 axis. Roburic acid can be used in research related to osteolytic diseases such as osteoporosis, colorectal cancer and inflammatory diseases.
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Cat. No.: HY-P70801
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1A; Tumor Necrosis Factor Receptor 1; Prev. TNFR1; TNF-RI; TNFAR; TNFR-I; Tumor Necrosis Factor Receptor Superfamily Member 1A; Tumor Necrosis Factor Receptor Superfamily, Member 1A; TNF-R-I; Tumor Necrosis Factor Binding Protein 1; TNF-R55; Tumor N
Species:  
Human
Source:  
E. coli
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Cat. No.: HY-P7305
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1A; Tumor Necrosis Factor Receptor 1; Prev. TNFR1; TNF-RI; TNFAR; TNFR-I; Tumor Necrosis Factor Receptor Superfamily Member 1A; Tumor Necrosis Factor Receptor Superfamily, Member 1A; TNF-R-I; Tumor Necrosis Factor Binding Protein 1; TNF-R55; Tumor N
Species:  
Human
Source:  
CHO
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Cat. No.: HY-P11833
CAS No.: 3053447-54-1
Target:  

TNF Receptor NF-κB

Research Areas:  

Inflammation/Immunology

TNFR1-IN-1 is a selective TNFR1 inhibitor with a Kd of 0.1 nM for hTNFR1. TNFR1-IN-1 inhibits TNFα-induced NF-κB signaling, with an IC50 value of 1.2 nM. TNFR1-IN-1 can be used in research related to inflammatory and immune diseases [1].
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Cat. No.: HY-P11834
CAS No.: 3053449-34-3
Target:  

TNF Receptor NF-κB

Research Areas:  

Inflammation/Immunology

TNFR1-IN-2 is a selective TNFR1 inhibitor with a Kd of 0.1 nM for hTNFR1. TNFR1-IN-1 inhibits TNFα-induced NF-κB signal transduction, with an IC50 value of 2.8 nM. TNFR1-IN-1 can be used in research related to inflammatory and immune diseases [1].
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Cat. No.: HY-P700263
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1A; Tumor Necrosis Factor Receptor 1; Prev. TNFR1; TNF-RI; TNFAR; TNFR-I; Tumor Necrosis Factor Receptor Superfamily Member 1A; Tumor Necrosis Factor Receptor Superfamily, Member 1A; TNF-R-I; Tumor Necrosis Factor Binding Protein 1; TNF-R55; Tumor N
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P700264
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1A; Tumor Necrosis Factor Receptor 1; Prev. TNFR1; TNF-RI; TNFAR; TNFR-I; Tumor Necrosis Factor Receptor Superfamily Member 1A; Tumor Necrosis Factor Receptor Superfamily, Member 1A; TNF-R-I; Tumor Necrosis Factor Binding Protein 1; TNF-R55; Tumor N
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-RS23455
Research Areas:  

Others

Tnfrsf1a Rat Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf1a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P700838
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1A; Tumor Necrosis Factor Receptor 1; Prev. TNFR1; TNF-RI; TNFAR; TNFR-I; Tumor Necrosis Factor Receptor Superfamily Member 1A; Tumor Necrosis Factor Receptor Superfamily, Member 1A; TNF-R-I; Tumor Necrosis Factor Binding Protein 1; TNF-R55; Tumor N
Species:  
Cynomolgus
Source:  
HEK293
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Cat. No.: HY-P82531
Synonyms: AA930854; TNFR1 associated DEATH domain protein; tradd

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P74504
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1A; Tumor Necrosis Factor Receptor 1; Prev. TNFR1; TNF-RI; TNFAR; TNFR-I; Tumor Necrosis Factor Receptor Superfamily Member 1A; Tumor Necrosis Factor Receptor Superfamily, Member 1A; TNF-R-I; Tumor Necrosis Factor Binding Protein 1; TNF-R55; Tumor N
Species:  
Rat
Source:  
HEK293
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Cat. No.: HY-P74505
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1A; Tumor Necrosis Factor Receptor 1; Prev. TNFR1; TNF-RI; TNFAR; TNFR-I; Tumor Necrosis Factor Receptor Superfamily Member 1A; Tumor Necrosis Factor Receptor Superfamily, Member 1A; TNF-R-I; Tumor Necrosis Factor Binding Protein 1; TNF-R55; Tumor N
Species:  
Rat
Source:  
HEK293
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Cat. No.: HY-P72443
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1A; Tumor Necrosis Factor Receptor 1; Prev. TNFR1; TNF-RI; TNFAR; TNFR-I; Tumor Necrosis Factor Receptor Superfamily Member 1A; Tumor Necrosis Factor Receptor Superfamily, Member 1A; TNF-R-I; Tumor Necrosis Factor Binding Protein 1; TNF-R55; Tumor N
Species:  
Mouse
Source:  
E. coli
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