2637243-08-2
Chemical Structure
(R)-Benpyrine
- CAS No.: 2637243-08-2
- Formula:C16H16N6O
- Molecular Weight:308.34
IUPAC Name: (R)-4-((9H-purin-6-yl)amino)-1-benzylpyrrolidin-2-one
InChIKey: HUWOMAVUXTXEKT-GFCCVEGCSA-N
SMILES: O=C(N(CC1=CC=CC=C1)C2)C[C@H]2NC3=C4C(NC=N4)=NC=N3
Biological Activity: (R)-Benpyrine is the isomer of Benpyrine (HY-133807), and can be used as an experimental control. Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1].
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(R)-Benpyrine | 99.08% | (R)-Benpyrine is the isomer of Benpyrine (HY-133807), and can be used as an experimental control. Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research. | ||||||||||||||||||||
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Keywords
