3053447-54-1
Chemical Structure
TNFR1-IN-1
- CAS No.: 3053447-54-1
- Formula:C104H122ClN21O22
- Molecular Weight:2053.66
InChIKey: JOMUSDINXORLJL-OADJCKAESA-N
SMILES: C[C@H]([C@@]1([H])C(N[C@]2([H])C[C@@](C(N[C@H](C(N[C@H](C(N3[C@](CNCC3)([H])C(N[C@H](C(N([C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@](C)(C(N[C@H](C(N[C@H](C(N(CC(N1)=O)C)=O)CC4=CC=C(C=C4)O)=O)CC5=CC=C(C=C5)C(O)=O)=O)CO)=O)CC(C6=CC=C7)=CNC6=C7Cl)=O)CC8=CC=NC=C8)=O)CC(N)=O)=O)CCC(O)=O)C)=O)CC9=CNC%10=CC=CC=C9%10)=O)=O)CC%11=CC=NC=C%11)=O)CCCC)=O)([H])CC2)=O)C(C%12=CC=C%13)=CNC%12=C%13OC
Biological Activity: TNFR1-IN-1 is a selective TNFR1 inhibitor with a Kd of 0.1 nM for hTNFR1. TNFR1-IN-1 inhibits TNFα-induced NF-κB signaling, with an IC50 value of 1.2 nM. TNFR1-IN-1 can be used in research related to inflammatory and immune diseases[1].
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TNFR1-IN-1 | TNFR1-IN-1 is a selective TNFR1 inhibitor with a Kd of 0.1 nM for hTNFR1. TNFR1-IN-1 inhibits TNFα-induced NF-κB signaling, with an IC50 value of 1.2 nM. TNFR1-IN-1 can be used in research related to inflammatory and immune diseases. | |||||||||||||||||||||
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Keywords
