380 Results for "

complement

" in MedChemExpress (MCE) Product Catalog:
Products (380)

380 Results for "complement" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-N9481
CAS No.: 56411-57-5
Lipoteichoic acid is an orally effect anti-inflammatory and antitumor agent. Lipoteichoic acid is a crucial immune molecule in Gram-positive bacteria that activates the complement system by inducing C3 and inhibiting CD55. Lipoteichoic acid regulates macrophage autophagy through the PI3K/Akt/mTOR pathway. Lipoteichoic acid induces lung damage in mice. Lipoteichoic acid inhibits the production of melanin .
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2 Cited Publications
Cat. No.: HY-P1345A
Target:  

Complement System

Research Areas:  

Neurological Disease Endocrinology

TLQP-21 TFA, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8μM). TLQP-21 TFA activates C3aR1 to induce an increase of intracellular Ca 2+. TLQP-21 TFA is used for the research in regulation of nociception and other relevant physiologic functions .
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2
2 Cited Publications
Cat. No.: HY-139588
CAS No.: 2086178-00-7
Purity:  98.61%
Synonyms: ALXN2050; ACH 0145228; ACH-5228
Vemircopan (ALXN2050) is an orally active complement factor D (FD) inhibitor. Vemircopan can be used in the research of diseases such as myasthenia gravis, lupus nephritis, IgA nephropathy, and paroxysmal nocturnal hemoglobinuria .
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2
2 Cited Publications
Cat. No.: HY-P70485
Purity:  ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: VTN; Vitronectin; VN; Serum Spreading Factor; Serum‑Spreading Factor; complement S‑Protein; Somatomedin B; S‑Protein; V75; Vitronectin (Serum Spreading Factor, Somatomedin B, complement S‑Protein); Epibolin; VNT
Species:  
Source:  
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2 Cited Publications
Cat. No.: HY-A0183
CAS No.: 1446756-47-3
Synonyms: Phospholipids, phosphatidylserines; Serine glycerophosphatides
Category:  

Animals

Target:  

Akt TGF-β Receptor

Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses .
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1
1 Cited Publications
Cat. No.: HY-P3252A
Target:  

Complement System

Research Areas:  

Inflammation/Immunology

Pegcetacoplan acetate is a pegylated complement C3/C3b inhibitor. Pegcetacoplan acetate acts by specifically binding to and inhibiting C3 and C3b, thereby suppressing the complement cascade at its proximal stage. Pegcetacoplan is not a known inhibitor or inducer of CYP450 isoenzymes. Pegcetacoplan acetate can be used for the research of complement-mediated diseases, including paroxysmal nocturnal hemoglobinuria (PNH) and age-related macular degeneration (AMD) .
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1
1 Cited Publications
Cat. No.: HY-128342
CAS No.: 2365402-67-9
Purity:  99.14%
Target:  

Complement System

Research Areas:  

Inflammation/Immunology

Compound C5-IN-1 (Compound 7) is a selective allosteric inhibitor of complement component protein C5. Compound C5-IN-1 prevents C5 from being cleaved by C5 convertase, inhibits the cleavage of C5 into C5a and C5b, and thus blocks the formation of membrane attack complex (MAC). Compound C5-IN-1 has an IC50 of 0.77 μM and 5 nM in 50% human whole blood and 2% human serum to block MAC deposition induced by zymosan, respectively. Compound C5-IN-1 can be used to study diseases related to complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .
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1 Cited Publications
Cat. No.: HY-P1505A
Synonyms: complement 3a (70-77) TFA
Target:  

Complement System

Research Areas:  

Inflammation/Immunology

C3a (70-77) TFA (Complement 3a (70-77) TFA) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a .
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1 Cited Publications
Cat. No.: HY-Y0641
CAS No.: 39515-51-0
Synonyms: m-Phenoxybenzaldehyde
Target:  

Complement System

Research Areas:  

Inflammation/Immunology

3-Phenoxybenzaldehyde has weak complement classical pathway inhibition and hemolytic activity .
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1
1 Cited Publications
Cat. No.: HY-P7864
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: C5; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4; complement C5; C5a Anaphylatoxin; CPAMD4; Prepro-C5; complement Component 5; Anaphylatoxin C5a Analog; C5a; ECLZB; C5b; C5D
Species:  
Source:  
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1 Cited Publications
Cat. No.: HY-P700862
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: C5; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4; complement C5; C5a Anaphylatoxin; CPAMD4; Prepro-C5; complement Component 5; Anaphylatoxin C5a Analog; C5a; ECLZB; C5b; C5D
Species:  
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1
1 Cited Publications
Cat. No.: HY-P72137
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CFB; complement Factor B Preproprotein; Prev. BFD; Glycine-Rich Beta Glycoprotein; Prev. BF; C3 Proaccelerator; Properdin Factor B; C3 Proactivator; C3/C5 Convertase; ARMD14; H2-Bf; AHUS4; B-Factor, Properdin; FBI12; Properdin B; CFAB; PBF2; CFBD; GBG; FB
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1 Cited Publications
Cat. No.: HY-P99905
CAS No.: 2375661-82-6
Synonyms: IBI302

Target:  

VEGFR

Efdamrofusp alfa is a bispecific fusion protein. Efdamrofusp alfa is capable of neutralizing both VEGF isoforms and C3b/C4b. Efdamrofusp alfa can be used for the research of neovascular age-related macular degeneration (nAMD) and other complement-related ocular conditions .
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1 Cited Publications
Cat. No.: HY-P74375
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: C2; complement Component 2; complement C2; complement Protein; C3/C5 Convertase; ARMD14; complement Component C2; CO2
Species:  
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1
1 Cited Publications
Cat. No.: HY-P75464
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: C1QB; complement Subcomponent C1q Chain B; complement C1q B Chain; complement C1q Chain B; complement Component 1, Q Subcomponent, Beta Polypeptide; complement Component C1q, B Chain; complement Component 1, Q Subcomponent, B Chain; C1QD2; complement C1q
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1 Cited Publications
Cat. No.: HY-P81185
Synonyms: C5; C6; C7; C8; C9; complement component 5; complement component 6; complement component 7; complement component 8; complement component 9; MAC; Membrane attack complex; TCC; Terminal complement complex.

Host:  

Rabbit

Application:  

WB, IHC-P, IHC-F, ICC/IF

Reactivity:  

Human, Rat

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1 Cited Publications
Cat. No.: HY-P71718
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: C1QA; complement Component 1, Q Subcomponent, A Chain; complement C1q A Chain; complement C1q Chain A; complement C1q Subcomponent Subunit A; complement Component C1q, A Chain; complement Component 1, Q Subcomponent, Alpha Polypeptide; C1QD1
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1 Cited Publications
Cat. No.: HY-P3204
CAS No.: 934461-40-2
Synonyms: AL-78898A
Target:  

Complement System

Research Areas:  

Metabolic Disease

POT-4 (AL-78898A), a Compstatin derivative, is a potent inhibitor of complement factor C3 activation. POT-4 can be used for age-related macular degeneration research
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1 Cited Publications
Cat. No.: HY-P7535
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CLU; complement-Associated Protein SP-40,40; Prev. APOJ; complement Lysis Inhibitor; Prev. CLI; Ku70-Binding Protein 1; Apolipoprotein J; NA1/NA2; TRPM-2; Clusterin (complement Lysis Inhibitor, SP-40,40, Sulfated Glycoprotein 2, Testosterone-Repressed Pro
Species:  
Source:  
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1 Cited Publications
Cat. No.: HY-P99730
CAS No.: 2227490-52-8
Synonyms: TAK-079

Target:  

CD38 Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Mezagitamab (TAK-079) is a IgG1λ anti-CD38 monoclonal antibody. Mezagitamab depletes tumor cells expressing CD38 through antibody and complement dependent cytotoxicity. Mezagitamab has potential application in relapsed/refractory multiple myeloma (RRMM) and idiopathic thrombocytopenic purpura (ITP) .
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