2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Efdamrofusp alfa

Efdamrofusp alfa is a bispecific fusion protein. Efdamrofusp alfa is capable of neutralizing both VEGF isoforms and C3b/C4b. Efdamrofusp alfa can be used for the research of neovascular age-related macular degeneration (nAMD) and other complement-related ocular conditions.

For research use only. We do not sell to patients.

Efdamrofusp alfa Chemical Structure

Efdamrofusp alfa Chemical Structure

CAS No. : 2375661-82-6

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Efdamrofusp alfa Related Antibodies

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1 Publications Citing Use of MCE Efdamrofusp alfa

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Description

Efdamrofusp alfa is a bispecific fusion protein. Efdamrofusp alfa is capable of neutralizing both VEGF isoforms and C3b/C4b. Efdamrofusp alfa can be used for the research of neovascular age-related macular degeneration (nAMD) and other complement-related ocular conditions[1].

In Vitro

Efdamrofusp alfa (0.135 mg/mL; 0, 6, 12, or 24 h) suppresses endothelial cell migration and tube formation[1].
Efdamrofusp alfa (0-1000 μg/mL) inhibits complement activation in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Efdamrofusp alfa Related Antibodies

Cell Migration Assay [1]

Cell Line: Human primary umbilical vein endothelial cell (HUVEC)
Concentration: 0.135 mg/mL
Incubation Time: 0, 6, 12, or 24 h
Result: Showed a 20.91% reduction in migration.
In Vivo

Efdamrofusp alfa (13.5 μg; 3 days) inhibits activation ofthe complement system in a mouse model oflaser-induced CNV[1].
Efdamrofusp alfa (1.35 mg; single intravitreal injection) shows favorable safety profiles and exhibited antiangiogenetic efficacy in a nonhuman primate laser-induced CNV model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice[1]
Dosage: 13.5 μg; 13.0 μg
Administration: 3 days; 7days
Result: Significantly reduced C3d deposition.
Reduced vascular leakage at 7 days after laser-induced injury.
Significantly suppressed CNV formation 7 days after laser-induced injury.
Reduced the concentrations of vitreous VEGF-A.
Animal Model: Rhesus monkeys[1]
Dosage: 1.35 mg
Administration: Single intravitreal injection
Result: Decreased the CNV leakage at 14 and 28 days and effectively reduced CNV volume 28 days.
CAS No.
SMILES

[Efdamrofusp alfa]
Storage

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Purity & Documentation
References
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Efdamrofusp alfa Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Efdamrofusp alfa2375661-82-6VEGFRVascular endothelial growth factor receptorfusion proteinVEGF isoformC3b/C4bneovascular age-related macular degeneration (nAMD)complementInhibitorinhibitorinhibit

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