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111974-74-4

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W040555
    Norquetiapine dihydrochloride
    1 Publications Verification

    N-Desalkylquetiapine dihydrochloride

    		 Drug Metabolite 5-HT Receptor HCN Channel Serotonin Transporter Neurological Disease
    Norquetiapine ( N-Desalkylauetiapine) dihydrochloride, a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC50 of 13.9 μM. Norquetiapine dihydrochloride selectively inhibits noradrenaline reuptake, is a partial 5-HT1A (Ki = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (Ki = 237 nM), 5-HT2C(Ki = 107 nM), and 5-HT7 (Ki = 76 nM) receptors. Norquetiapine dihydrochloride blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine dihydrochloride shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine dihydrochloride can be used for the study of depression and inflammation .
    Norquetiapine dihydrochloride
  • HY-W040555R
    Norquetiapine dihydrochloride (Standard)

    N-Desalkylquetiapine dihydrochloride (Standard)

    		 Reference Standards
    11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride (Standard) is the analytical standard of 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride. This product is intended for research and analytical applications.
    Norquetiapine dihydrochloride (Standard)
  • HY-W052508
    Norquetiapine
    1 Publications Verification

    N-Desalkylquetiapine

    		 Drug Metabolite 5-HT Receptor HCN Channel Serotonin Transporter Neurological Disease
    Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC50 of 13.9 μM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT1A (Ki = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (Ki = 237 nM), 5-HT2C(Ki = 107 nM), and 5-HT7 (Ki = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation .
    Norquetiapine

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