1 Result for "

1446322-73-1

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "1446322-73-1" in MCE Product Catalog:

Cat. No.: HY-P10426
CAS No.: 1446322-73-1
Research Areas:  

Cancer

cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers .
loading...
    loading...