3 Results for "

1781223-80-0

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "1781223-80-0" in MCE Product Catalog:

Cat. No.: HY-P99391
CAS No.: 1781223-80-0
Synonyms: ABT-700; ABBV-400 Antibody

Target:  

c-Met/HGFR Apoptosis

Research Areas:  

Cancer

Telisotuzumab (ABT-700) is a bivalent humanized IgG1 anti-c-Met monoclonal antibody. Telisotuzumab binds cellular c-Met and disrupts its productive dimerization and activation induced by HGF or by the high density of c-Met on the cell surface independent of ligand. Telisotuzumab induces apoptosis. Telisotuzumab can be used for the study of cancers harboring amplified MET, such as gastric and lung cancers .
loading...
    loading...
Cat. No.: HY-P99391A
CAS No.: 1781223-80-0
Synonyms: ABT-700 (powder)

Target:  

c-Met/HGFR Apoptosis

Research Areas:  

Cancer

Telisotuzumab (ABT-700) (powder) is a bivalent humanized IgG1 anti-c-Met monoclonal antibody. Telisotuzumab (powder) binds cellular c-Met and disrupts its productive dimerization and activation induced by HGF or by the high density of c-Met on the cell surface independent of ligand. Telisotuzumab (powder) induces apoptosis. Telisotuzumab (powder) can be used for the study of cancers harboring amplified MET, such as gastric and lung cancers .
loading...
    loading...
Cat. No.: HY-P99391B
CAS No.: 1781223-80-0
Synonyms: ABT-700 (WT IgG1); ABBV-400 Antibody (WT IgG1)
Target:  

c-Met/HGFR

Research Areas:  

Cancer

Telisotuzumab (WT IgG1) is a monoclonal antibody that retains the natural wild-type IgG1 Fc structure without engineering modification. Telisotuzumab (HY-P99391) is a humanized IgG1 anti-c-Met monoclonal antibody whose Fc hinge region has been engineered to introduce additional cysteine ​​coupling sites for targeted drug conjugation .
loading...
    loading...