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2445565-58-0

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "2445565-58-0" in MCE Product Catalog:

Cat. No.: HY-146307
CAS No.: 2445565-58-0
Target:  

TrxR

Research Areas:  

Cancer

TrxR-IN-3 (Compound 2c) is a potent inhibitor of TrxR. TrxR-IN-3 exhibits potent antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and resulted in marked apoptosis by regulating apoptosis-related proteins expressed in the breast cancer cells. TrxR-IN-3 also triggers the formation of autophagosomes and autolysosomes by promoting the expression of LC3-II and Beclin-1 and diminishing the expression of LC3-I and p62 proteins .
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