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2599098-78-7

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "2599098-78-7" in MCE Product Catalog:

Cat. No.: HY-184471
CAS No.: 2599098-78-7
Research Areas:  

Cancer

BCL-XL-IN-5 is an orally active, highly selective BH3-mimetic BCL-XL inhibitor with a cKi of 7.96 pM. BCL-XL-IN-5 triggers caspase-3 activation and robust PARP cleavage to initiate apoptosis in BCL-XL-dependent MOLT-4 T-cell acute lymphoblastic leukemia cells. BCL-XL-IN-5 serves as a potent selective probe for investigating BCL-XL-dependent malignancies, such as acute lymphoblastic leukemia .
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