1 Result for "

2635386-51-3

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "2635386-51-3" in MCE Product Catalog:

Cat. No.: HY-180979
CAS No.: 2635386-51-3
Target:  

PROTACs Bcr-Abl

Research Areas:  

Cancer

P22D is a BCR-ABL PROTAC degrader based on Dasatinib (HY-10181), with a DC50 value of approximately 10 nM for the wild-type BCR-ABL protein. P22D cannot degrade the BCR-ABL T315I mutant. P22D has inhibitory activity against K562 cells (wild type), but is ineffective against BaF3-BCR-ABL (T315I) cells. P22D can be used for research on chronic myeloid leukemia and acute lymphocytic leukemia .
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