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319-78-8

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D-Isoleucine
D-Isoleucine
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Cat. No.: HY-I1070
CAS No.: 319-78-8
Synonyms: (R)-Isoleucine
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

ASCT

D-Isoleucine is a selective competitive activator of the Asc-1 antiporter (Ki=0.98 mM). D-Isoleucine promotes the release of D-serine and glycine by binding to the Asc-1 protein on the neuronal cell membrane, and enhances NMDA receptor-dependent synaptic plasticity. D-Isoleucine can be used in the study of neurodegenerative diseases (such as Alzheimer's disease and schizophrenia). D-Isoleucine also acts as a non-classical D-amino acid, interferes with bacterial peptidoglycan synthesis, and inhibits the formation of Staphylococcus aureus biofilm, and has potential antibacterial application value[1][2].
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