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54627-18-8

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "54627-18-8" in MCE Product Catalog:

N-Palmitoyl-D-glucosamine
N-Palmitoyl-D-glucosamine
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Cat. No.: HY-N19801
CAS No.: 54627-18-8
Category:  

Natural Products Microorganisms

Target:  

Toll-like Receptor (TLR) NF-κB Interleukin Related TNF Receptor

N-Palmitoyl-D-glucosamine is an orally active TLR4 antagonist. N-Palmitoyl-D-glucosamine stably binds MD-2 with, preventing LPS-induced NF-κB signaling, decreases pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), increases anti-inflammatory IL-10 and IL-1rα, and normalizes miR-20a-5p, miR-106a-5p, and miR-27a-3p levels. N-Palmitoyl-D-glucosamine decreases allodynia and prevents myelino-axonal degeneration of peripheral nerves. N-Palmitoyl-D-glucosamine can be used for the researches of keratitis and peripheral neuropathy .
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