2 Results for "

6926-14-3

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "6926-14-3" in MCE Product Catalog:

1
8-​O-​Acetylharpagide
8-​O-​Acetylharpagide
0 Images
1 Cited Publications
Cat. No.: HY-N0757
CAS No.: 6926-14-3
Category:  

Infection other families Iridoids Terpenoids Plants Disease Research Fields Inflammation/Immunology

Target:  

Akt Bcl-2 Family Apoptosis Adrenergic Receptor

8-O-Acetylharpagide is an orally active iridoid glycoside compound. 8-O-Acetylharpagide exhibits anti-aging activity at low doses and anticancer activity at high doses. 8-O-Acetylharpagide induces late-stage apoptosis and necrosis-like death in cancer cells, and downregulates anti-apoptotic proteins such as Akt, p-Akt and Bcl-2. 8-O-Acetylharpagide is mainly metabolized in rats via demethylation, hydrolysis and glucuronidation, and its active metabolites downregulate the AKT/NF-κB/MMP9 signaling axis. 8-O-Acetylharpagide exerts vasoconstrictive effects by activating vascular α-adrenoceptor .
loading...
    loading...
View All Sizes
8-O-Acetylharpagide (Standard)
8-O-Acetylharpagide (Standard)
0 Images
Cat. No.: HY-N0757R
CAS No.: 6926-14-3
Category:  

other families Iridoids Terpenoids Plants

Target:  

Reference Standards Akt Bcl-2 Family Apoptosis Adrenergic Receptor

8-O-Acetylharpagide (Standard) is the analytical standard of 8-O-Acetylharpagide. This product is intended for research and analytical applications. 8-O-Acetylharpagide is an iridoid glycoside compound. 8-O-Acetylharpagide exhibits anti-aging activity at low doses and anticancer activity at high doses. 8-O-Acetylharpagide induces late-stage apoptosis and necrosis-like death in cancer cells, and downregulates anti-apoptotic proteins such as Akt, p-Akt and Bcl-2. 8-O-Acetylharpagide is mainly metabolized in rats via demethylation, hydrolysis and glucuronidation, and its active metabolites downregulate the AKT/NF-κB/MMP9 signaling axis. 8-O-Acetylharpagide exerts vasoconstrictive effects by activating vascular α-adrenoceptor.
loading...
    loading...
View All Sizes
Assay Types