2 Results for "

74805-90-6

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "74805-90-6" in MCE Product Catalog:

Methylophiopogonone A
Methylophiopogonone A
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Cat. No.: HY-N2441
CAS No.: 74805-90-6
Category:  

Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Flavonoids Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Other Flavonoids

Target:  

NO Synthase Collagen p38 MAPK

Methylophiopogonone A is a homoisoflavonoid compound found in the tuberous roots of Ophiopogon japonicus. Methylophiopogonone A inhibits lipopolysaccharide-induced NO production in mouse microglia with an IC50 of 19.2 μM. Methylophiopogonone A blocks the proliferation of LX-2 hepatic stellate cells and downregulates TGF-β1-induced expressions of type I collagen and α-SMA. Methylophiopogonone A blocks RELA/EGFR-mediated hepatic stellate cell activation, inhibits the MAPK12 pathway to reduce extracellular matrix accumulation, and simultaneously suppresses inflammatory signal transduction. Methylophiopogonone A can be used in studies related to chronic hepatitis B-associated hepatic fibrosis and neuroinflammation .
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Methylophiopogonone A (Standard)
Methylophiopogonone A (Standard)
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Cat. No.: HY-N2441R
CAS No.: 74805-90-6
Category:  

Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Flavonoids Phenols Polyphenols Plants Other Flavonoids

Target:  

Reference Standards NO Synthase Collagen p38 MAPK

Methylophiopogonone A (Standard) is the analytical standard of Methylophiopogonone A (HY-N2441). This product is intended for research and analytical applications. Methylophiopogonone A is a homoisoflavonoid compound found in the tuberous roots of Ophiopogon japonicus. Methylophiopogonone A inhibits lipopolysaccharide-induced NO production in mouse microglia with an IC50 of 19.2 μM. Methylophiopogonone A blocks the proliferation of LX-2 hepatic stellate cells and downregulates TGF-β1-induced expressions of type I collagen and α-SMA. Methylophiopogonone A blocks RELA/EGFR-mediated hepatic stellate cell activation, inhibits the MAPK12 pathway to reduce extracellular matrix accumulation, and simultaneously suppresses inflammatory signal transduction. Methylophiopogonone A can be used in studies related to chronic hepatitis B-associated hepatic fibrosis and neuroinflammation .
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