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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
8-oxo-dG
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "8-oxo-dG" in MCE Product Catalog:
17
17 Cited Publications
Cat. No.: HY-P81140
Synonyms: 8-hydroxy-2'-deoxyguanosine; 2'-Deoxy-8-oxoguanosine; 7,8-Dihydro-8-oxo-2'-deoxyguanosine; 8-oxo-7,8-dihydro-2'-deoxyguanosine; 8-oxo-7,8-dihydrodeoxyguanosine; 2'-Deoxy-8-oxo-D-guanosine; 8-oxo-7,8-dihydro-2μ-deoxyguanosine,8-oxo-dG; 2'-Deoxy-8-hydroxyguanosine;
Cat. No.: HY-171230
CAS No.: 2803422-60-6
Target:
Research Areas:
MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. MTH1 activator-1 can be used to probe the cellular and biological effects of upregulated oxidative damage repair in nucleotide pools and to delay or abrogate tumorigenesis .
Cat. No.: HY-W1121772
CAS No.: 1850359-96-4
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8-Oxo-dG(dmf)phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
Cat. No.: HY-12814A
CAS No.: 1640282-30-9
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Research Areas:
TH588 hydrochloride is a highly selective human MTH1 inhibitor (IC50=5 nM) with additional microtubule-targeting properties. TH588 hydrochloride interferes with mitotic progression, induces genomic 8-oxodG formation, DNA damage and cell cycle arrest, and exhibits significant cytotoxicity. Combined with phenethyl isothiocyanate, TH588 hydrochloride enhances ROS-mediated effects and effectively inhibits the growth of visceral metastases of malignant melanoma in mice. TH588 hydrochloride is widely applicable to research related to cancers, pancreatic cancer, leukemia, lymphoma, malignant melanoma and lung cancer .
Cat. No.: HY-W854193
CAS No.: 143060-53-1
Target:
Research Areas:
Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-7,8-dihydro-N-(2-methyl-1-oxopropyl)-8-oxo-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] is a phosphoramidite that can be used in the synthesis of oligonucleotides.
Cat. No.: HY-132974
CAS No.: 165179-35-1
Synonyms: NSC-686288
Target:
Aryl Hydrocarbon Receptor Reactive Oxygen Species (ROS) DNA Alkylator/Crosslinker DNA/RNA Synthesis Caspase Apoptosis HIF/HIF Prolyl-Hydroxylase
Research Areas:
Aminoflavone is an anti-tumor agent. Aminoflavone inhibits the expression of ITGA6/SOX2 by activating the AhR-miR-125b-2-3p axis, thereby targeting breast cancer stem cells. Aminoflavone induces an increase in intracellular ROS, increases the level of oxidative DNA damage marker 8-oxodG and DNA-protein cross-links. Aminoflavone causes S-phase arrest, activates caspase-3/8/9 and induces apoptosis (apoptosis). Aminoflavone inhibits HIF-1α expression in a manner independent of AhR. Aminoflavone can be used for the study of breast cancer .
Cat. No.: HY-P811649
Synonyms: 8-hydroxy-2'-deoxyguanosine; 2'-Deoxy-8-oxoguanosine; 7,8-Dihydro-8-oxo-2'-deoxyguanosine; 8-oxo-7,8-dihydro-2'-deoxyguanosine; 8-oxo-7,8-dihydrodeoxyguanosine; 2'-Deoxy-8-oxo-D-guanosine; 8-oxo-7,8-dihydro-2μ-deoxyguanosine,8-oxo-dG; 2'-Deoxy-8-hydroxyguanosine;
Cat. No.: HY-180404
CAS No.: 2598151-90-5
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Research Areas:
SU0383 is a dual MTH1 and OGG1 inhibitor with IC50 values of 0.034 μM and 0.49 μM, respectively. SU0383 induces cytotoxicity in cancer cells and increases sensitivity of tumor cells to oxidative stress, and showing low toxicity in normal cells. SU0383 can be used for cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
