2598151-90-5
Chemical Structure
SU0383
- CAS No.: 2598151-90-5
- Formula:C33H34N6O5S
- Molecular Weight:626.73
IUPAC Name: N-(2-((2-amino-5-methylpyrimidin-4-yl)oxy)ethyl)-4'-(N-(1-(cyclopropanecarbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)sulfamoyl)-[1,1'-biphenyl]-3-carboxamide
InChIKey: KIUIIVGLTWYGNU-UHFFFAOYSA-N
SMILES: O=C(NCCOC1=NC(=NC=C1C)N)C=2C=CC=C(C2)C=3C=CC(=CC3)S(=O)(=O)NC4=CC=C5C(=C4)N(C(=O)C6CC6)CCC5
Biological Activity: SU0383 is a dual MTH1 and OGG1 inhibitor with IC50 values of 0.034 μM and 0.49 μM, respectively. SU0383 induces cytotoxicity in cancer cells and increases sensitivity of tumor cells to oxidative stress, and showing low toxicity in normal cells. SU0383 can be used for cancer research[1][2].
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SU0383 | SU0383 is a dual MTH1 and OGG1 inhibitor with IC50 values of 0.034 μM and 0.49 μM, respectively. SU0383 induces cytotoxicity in cancer cells and increases sensitivity of tumor cells to oxidative stress, and showing low toxicity in normal cells. SU0383 can be used for cancer research. | |||||||||||||||||||||
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Keywords
