2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. SU0383

SU0383 is a dual MTH1 and OGG1 inhibitor with IC50 values of 0.034 μM and 0.49 μM, respectively. SU0383 induces cytotoxicity in cancer cells and increases sensitivity of tumor cells to oxidative stress, and showing low toxicity in normal cells. SU0383 can be used for cancer research.

For research use only. We do not sell to patients.

SU0383

SU0383 Chemical Structure

CAS No. : 2598151-90-5

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Description

SU0383 is a dual MTH1 and OGG1 inhibitor with IC50 values of 0.034 μM and 0.49 μM, respectively. SU0383 induces cytotoxicity in cancer cells and increases sensitivity of tumor cells to oxidative stress, and showing low toxicity in normal cells. SU0383 can be used for cancer research[1][2].

IC50 & Target[1]

MTH1

0.034 μM (IC50)

OGG1

0.49 μM (IC50)

In Vitro

SU0383 (5-20 µM; 24-72 h) induces cytotoxicity at 20 μM in A549, H460, and HCT116 cells[1].
SU0383 (0.01-10 μM; 24 h) shows low toxicity in MCF-7 and HeLa cells[2].
SU0383 (10 μM; 16 h) increases the sensitivity of MCF-7 tumor cells to oxidative stress induced by hydrogen peroxide[2].
SU0383 (10 μM) engages native NUDT1 in MCF7 cells and inhibits native OGG1 activity in MCF7 lysate[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SU0383 Related Antibodies

Cell Viability Assay[1]

Cell Line: A549, H460, HCT116
Concentration: 5-20 μM
Incubation Time: 24, 48, 72 h
Result: Induced noticeable cytotoxicity only at 20 μM in A549, H460, and HCT116 cells.
Showed no significant cytotoxicity at lower concentrations.

Cell Cytotoxicity Assay[2]

Cell Line: MCF-7 and HeLa human cell lines
Concentration: 0.01, 0.1, 1, 10 μM
Incubation Time: 24 h
Result: Displayed little or no measurable toxicity in MCF-7 and HeLa cells at concentrations up to 10 μM.
Molecular Weight

626.73

Formula

C33H34N6O5S
CAS No.
SMILES

O=C(NCCOC1=NC(=NC=C1C)N)C=2C=CC=C(C2)C=3C=CC(=CC3)S(=O)(=O)NC4=CC=C5C(=C4)N(C(=O)C6CC6)CCC5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SU0383 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SU03832598151-90-5SU 0383SU-0383DNA/RNA Synthesislung adenocarcinomaMTH1OGG1tumor cellshuman cellsoxidative stressA549cancer cells8-oxo-dGoxidative DNA damageInhibitorinhibitorinhibit

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