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Results for "

APP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (5) Adrenergic Receptor (3) Akt (2) Aldehyde Dehydrogenase (ALDH) (1) Amine N-methyltransferase (1) Amino Acid Derivatives (3) Aminoacyl-tRNA Synthetase (2) Aminopeptidase (2) Amyloid-β (46) Antibiotic (1) AP-1 (1) Apolipoprotein (1) Apoptosis (14) Atg8/LC3 (1) Autophagy (6) Bacterial (2) Bcl-2 Family (2) BCRP (1) Beta-secretase (13) Biochemical Assay Reagents (1) Btk (1) Calcium Channel (1) Cannabinoid Receptor (1) Caspase (3) Cathepsin (2) CDK (1) Cholinesterase (ChE) (4) Deubiquitinase (1) Dihydroorotate Dehydrogenase (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (3) Dopamine Transporter (1) Drug Derivative (3) Drug Intermediate (1) Drug Isomer (1) Endogenous Metabolite (1) Enteropeptidase (1) Ferrochelatase (1) Ferroptosis (2) Fluorescent Dye (3) G Protein-coupled Receptor Kinase (GRK) (1) Glutathione Peroxidase (2) GPR39 (1) GSK-3 (2) HDAC (1) Histamine Receptor (3) Histone Methyltransferase (1) IAP (1) IFNAR (1) IMPDH (1) Interleukin Related (2) IRE1 (1) JAK (1) JNK (1) Kinesin (3) MAP3K (2) MAPKAPK2 (MK2) (1) MEK (1) mGluR (1) Mitochondrial Metabolism (1) Monoamine Oxidase (1) nAChR (2) NADPH Oxidase (1) NF-κB (3) OGA (1) p97 (1) Parasite (1) Phosphatase (4) PI3K (1) PI4K (1) PPAR (1) Ras (1) Reactive Oxygen Species (ROS) (3) Reference Standards (3) RIP kinase (2) RUNX (1) Small Interfering RNA (siRNA) (3) Src (1) STAT (1) Survivin (1) Tau Protein (2) TGF-β Receptor (1) Thrombin (3) TMV (1) TRP Channel (1) Tyrosinase (1) VEGFR (1) α-synuclein (3) γ-secretase (7)
By Research Areas:	Cancer (22) Cardiovascular Disease (11) Endocrinology (4) Infection (13) Inflammation/Immunology (18) Metabolic Disease (3) Neurological Disease (78)
Click Chemistry:	Alkynes (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) siRNA drugs (2) Human Pre-designed siRNA Sets (1) siRNAs (5)

132

Inhibitors & Agonists

Fluorescent Dye

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Inhibitory Antibodies

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10254

Mirdametinib Maximum Cited Publications 155 Publications Verification PD0325901; PD325901	MEK Autophagy Apoptosis	Cancer
Mirdametinib (PD0325901) is an orally active, selective and non-ATP-competitive MEK inhibitor with an IC₅₀ of 0.33 nM. Mirdametinib exhibits a K_i ^app of 1 nM against activated MEK1 and MEK2. Mirdametinib suppresses the expression of p-ERK1/2 and induces apoptosis. Mirdametinib has anti-cancer activity for a broad spectrum of human tumor xenografts .

HY-50759

Ispinesib 5+ Cited Publications SB-715992; CK-0238273	Kinesin Apoptosis	Cancer
Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a K_{i app} of 1.7 nM.

HY-N0192

Arbutin 3 Publications Verification β-Arbutin	Tyrosinase Endogenous Metabolite	Cancer
Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with K_i ^app values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents . Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties .

HY-106005

MMV390048 3 Publications Verification	Parasite PI4K	Infection
MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (K_d ^app=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent .

HY-129430

N-Methylprotoporphyrin IX 1 Publications Verification	Ferrochelatase	Metabolic Disease
N-Methylprotoporphyrin IX is a Ferrochelatase inhibitor with a K_i ^app value of 3 nM. N-methylprotoporphyrin IX dimethyl ester potently inhibits the synthesis of phycocyanin and chlorophyll a. N-Methylprotoporphyrin IX can be used for the research of haem deficiency-associated disorders .

HY-15294

CZC24832	PI3K	Inflammation/Immunology Cancer
CZC24832 is a highly selective and potent PI3Kγ inhibitor (IC₅₀=27 nM) with apparent dissociation constants (K_d ^app) of 19 nM.

HY-50883

BMS 299897	γ-secretase	Neurological Disease
BMS 299897 is a sulfonamide γ-secretase inhibitor with an IC₅₀ of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).

HY-P99185

Bapineuzumab AAB-001	Amyloid-β	Neurological Disease
Bapineuzumab is an anti-β-amyloid protein (APP) monoclonal antibody. Bapineuzumab is a humanized IgG1 that recognizes the N terminus of Aβ cleared plaques from the brains. Bapineuzumab can be used for the research of Alzheimer’s disease (AD) .

HY-13769A

TPT-260 Dihydrochloride 2 Publications Verification NSC55712; TPU-260 Dihydrochloride	Drug Derivative Amyloid-β Beta-secretase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
TPT-260 Dihydrochloride (NSC55712), a thiophene thiourea derivative, is a retromer complex stabilizer against thermal denaturation (K_d = ~5 µM). TPT-260 Dihydrochloride increases the levels of retromer proteins, shifts amyloid-precursor protein (APP) away from the endosome, and decreases the pathogenic processing of APP. TPT-260 Dihydrochloride inhibits TLR4 upregulation, IKKβ phosphorylation, NF-κB p65 nuclear translocation, and NLRP3 inflammasome formation. TPT-260 Dihydrochloride improves retromer-mediated cargo trafficking, reduces brain infarct area, and decreases amyloid plaque deposition. TPT-260 Dihydrochloride exhibits minimal cytotoxicity to primary microglia at tested concentrations. TPT-260 Dihydrochloride can be used for the research of inflammatory bowel disease, ischemic stroke and Alzheimer's disease .

HY-114174

Fmoc-Ala-Glu-Asn-Lys-NH2 3 Publications Verification	Amyloid-β	Neurological Disease
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing .

HY-124832

δ-Secretase inhibitor 11 1 Publications Verification	Caspase Amyloid-β	Neurological Disease
δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC₅₀ of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research .

HY-129096

IDT307 2 Publications Verification	Fluorescent Dye	Others
IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+) .

HY-128464

LL320	Amine N-methyltransferase	Metabolic Disease
LL320 is a selective NNMT inhibitor with a *K_i,app* of 6.8 nM. LL320 exhibits interactions with RNMT, DPH₅, and SAHH .

HY-14537

Latrepirdine dihydrochloride Dimebolin dihydrochloride	Amyloid-β Histamine Receptor Adrenergic Receptor 5-HT Receptor Autophagy	Neurological Disease Endocrinology
Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.

HY-128585

GNE684	RIP kinase	Inflammation/Immunology Cancer
GNE684 is a potent inhibitor of potent receptor interacting protein 1 (RIP1), with mean K_i ^app values of 21 nM, 189 nM and 691 nM for human mouse and rat RIP1, respectively .

HY-109536B

Ammonium polyphosphate, n<20, water solubility>90 g/100 mL	Biochemical Assay Reagents	Others
Ammonium polyphosphate, n<20, water solubility>90 g/100 mL, a low-polymerization-degree ammonium polyphosphate (APP), is an important raw material in chelated, and controlled-release fertilizers .

HY-103374

Phenserine (-)-Eseroline phenylcarbamate; (-)-Phenserine	Cholinesterase (ChE) Amyloid-β	Neurological Disease
Phenserine ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine (HY-N6608) and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine improves cognitive performance and attenuates the progression of Alzheimer's disease .

HY-P6365B

APP-018 D-4F	Apolipoprotein	Cardiovascular Disease
APP-018 (D-4F) is 18 D-amino acids peptide that mimics apolipoprotein A-I (apoA-I). APP-018 improves the anti-inflammatory activity of high-density lipoprotein (HDL). APP-018 can be used in researches of cardiovascular diseases .

HY-18292

ARN2966	Amyloid-β	Neurological Disease
ARN2966 is a potent, orally active and cross the blood-brain barrier *amyloid precursor protein (APP) translation* modulator.

HY-108643

CMPD1	MAPKAPK2 (MK2)	Cancer
CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with apparent K_i (K_i ^app) of 330 nM .

HY-14862

Latrepirdine Dimebolin; Dimebone	Amyloid-β Histamine Receptor Adrenergic Receptor 5-HT Receptor Autophagy	Endocrinology
Latrepirdine is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.

HY-12989

LDN-91946	Deubiquitinase	Neurological Disease Cancer
LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a K_{i app} of 2.8 μM .

HY-161110

APP degrader-1	Amyloid-β	Neurological Disease
APP degrader-1 (Compound 0152) is an orally active amyloid precursor protein (APP) degrader that induces *APP* degradation and reduces the extracellular release of Aβ42. APP degrader-1 can bind to both CAPRIN1 and *APP, and enhances their interaction as well as CAPRIN1-mediated APP* degradation through the endosome-lysosome pathway .

HY-12856

GSK503 5+ Cited Publications	Histone Methyltransferase	Cancer
GSK503 is a potent and specific inhibitor of EZH2 methyltransferase with K_i ^app values of 3 to 27 nM.

HY-153986

AEP-IN-2	Cathepsin	Neurological Disease
AEP-IN-2 is an asparagine endopeptidase (AEP) inhibitor via block AEP cleavage of APP and Tau. AEP-IN-2 has oral activity and decreases Aβ40 and Aβ42 and p-Tau levels .

HY-P1378A

β-Amyloid (1-43)(human) TFA	Amyloid-β	Neurological Disease
β-Amyloid (1-43)(human) TFA is more prone to aggregation and has higher toxic properties than the long-known Aβ1-42. β-Amyloid (1-43)(human) TFA shows a correlation with both sAPPα and sAPPβ. β-Amyloid (1-43)(human) TFA could be considered an added Alzheimer's disease (AD) biomarker together with the others already in use .

HY-117924

AUTEN-67 Autophagy enhancer-67	Autophagy	Neurological Disease
AUTEN-67 (Autophagy enhancer-67) is an orally active autophagy enhancer and MTMR14 inhibitor. AUTEN-67 has anti-aging and neuroprotective effects. AUTEN-67 protects neurons from stress-induced cell death. AUTEN-67 also restores nesting behavior in a mice model of Alzheimer disease .

HY-171347

gamma-secretase modulator 6	γ-secretase Amyloid-β	Neurological Disease
gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. gamma-secretase modulator 6 inhibits Aβ42 secretion in HEK cell line stably expressing APP (Aβ amyloid precursor protein) (pIC₅₀: 8.1). gamma-secretase modulator 6 can be used for research of Alzheimer's disease .

HY-RS00863

APP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
APP Human Pre-designed siRNA Set A contains three designed siRNAs for APP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

APP Human Pre-designed siRNA Set A APP Human Pre-designed siRNA Set A

HY-128090A

Apstatin TFA	Aminopeptidase	Cardiovascular Disease
Apstatin TFA is a potent aminopeptidase P (APP) inhibitor with K_i values of 2.6, 0.64 µM for rat and human APP, respectively. Apstatin TFA shows cardioprotection .

HY-50882

ELN318463	γ-secretase	Neurological Disease
ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC₅₀s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN318463 is 51-fold more selective for PS1 .

HY-136499

DI-82	DNA/RNA Synthesis	Cancer
DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC₅₀ ^app of 27.8 nM and K_i ^app of 9.2 nM. DI-82 has antitumor activity .

HY-139973

OAB-14	Amyloid-β	Neurological Disease
OAB-14, is a Bexarotene (HY-14171) derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice. OAB-14 effectively ameliorates the dysfunction of the endosomal-autophagic-lysosomal pathway in APP/PS1 transgenic mice .

HY-107164

Thiomarinol A 4-Hydroxythiomarinol C	Antibiotic Bacterial	Infection
Thiomarinol A (4-Hydroxythiomarinol C) is a potent antibiotic. Thiomarinol A is a hybrid of dithiolopyrrolone and marinolic acid. Thiomarinol A shows antimicrobial activity. Thiomarinol A inhibits MRSA IleRS in a dose-dependent with a K_i ^app value of 19 nM .

HY-P4885

Glp-amyloid-β (3-40) peptide (human) AβpE3-40	Amyloid-β	Neurological Disease
Glp-Amyloid-β (3-40) Peptide (human) (AβpE3-40) is a minor amounts of pyroglutamate-modified Aβ isolated from from 24-month-old Amyloid precursor protein (APP) transgenic Mice .

HY-108966

Kushenol C	Beta-secretase	Inflammation/Immunology
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits *BACE1 (β-site APP* cleaving enzyme 1) with an IC₅₀** of 5.45 µM .

HY-176749

HUP-46	α-synuclein Atg8/LC3 Autophagy	Neurological Disease
HUP-46 is a BBB-penatrable modulator of αSyn dimerization and autophagy. HUP-46 reduces the ratio of pPP2A/PP2A, increases the autophagy marker LC3BII levels, and decreases αSyn dimerization. HUP-46 can be used for research of neurodegenerative diseases .

HY-169296

IMPDH2-IN-4	IMPDH	Cancer
IMPDH2-IN-4 (Compound 2d) is a selective IMPDH2 inhibitor with a *K_i,app* value of 1.8 μM. IMPDH2-IN-4 exhibits anti-cancer activity against osteosarcoma. IMPDH2-IN-4 can be used in research related to osteosarcoma .

HY-N1414A

3′,6-Disinapoylsucrose 2 Publications Verification	Bcl-2 Family Apoptosis	Neurological Disease
3′,6-Disinapoylsucrose is a type of oligosaccharide that's effective when taken orally, and it has antidepressant, anti-anxiety, and antioxidant properties. 3′,6-Disinapoylsucrose inhibits neuronal apoptosis by lowering the ratio of Bax to Bcl-2 in hippocampal neurons, and it enhances cognitive function in APP/PS1 transgenic mice by activating the CREB/BDNF signaling pathway .

HY-177646

Mivelsiran ALN-APP	Amyloid-β	Neurological Disease
Mivelsiran is a siRNA targeted to amyloid-beta precursor protein (APP). It is used for the study of Alzheimer's disease.

HY-P991130

Dalidnetug	Amyloid-β	Neurological Disease
Dalidnetug is a humanized monoclonal antibody targeting human amyloid-beta precursor protein (APP). Dalidnetug specifically binds to *APP* to reduce the production of amyloid-beta (Aβ), thus exerting the activity of clearing amyloid-beta. Dalidnetug is promising for research of Alzheimer's disease .

HY-P1894

β-Amyloid Protein Precursor 770 (135-155)	Amyloid-β	Neurological Disease
β-Amyloid Protein Precursor 770 (135-155) is a peptide of amyloid precursor protein isoform (APP 770). APP 770 produces Aβ40/42 .

HY-149397

FXIIa-IN-2	Thrombin	Cardiovascular Disease
FXIIa-IN-1-IN-2 (Compound 21) is a Factor XIIa inhibitor (K_i ^app: 62.2 nM). FXIIa-IN-1-IN-2 can be used for research of thrombosis .

HY-144741

BACE1-IN-9	Beta-secretase	Neurological Disease
BACE1-IN-9 (compound 82b) is a potent BACE1 (β-site APP cleaving enzyme 1) inhibitor, with an IC₅₀ of 1.2 µM .

HY-121817

Sulfiram	Aldehyde Dehydrogenase (ALDH) Drug Intermediate Amyloid-β	Infection Neurological Disease
Sulfiram is a very weak aldehyde dehydrogenase (ALDH) inhibitor, with an IC₅₀ value of 413 μM against Saccharomyces cerevisiae ALDH. As a photochemical precursor, Sulfiram undergoes photoconversion to form Disulfiram (HY-B0240), a potent ALDH inhibitor. Sulfiram inhibits the dimerization of the extracellular domain fragment (amino acid residues 230-624) of amyloid precursor protein (APP), alters the monomer-dimer equilibrium, induces conformational changes in the fragment, and enhances the production of sAPPα via α-cleavage of APP. Sulfiram can be used in research related to scabies and Alzheimer's disease .

HY-P1378

β-Amyloid (1-43)(human)	Amyloid-β	Neurological Disease
β-Amyloid (1-43)(human) is more prone to aggregation and has higher toxic properties than the long-known Aβ1-42. β-Amyloid (1-43)(human) shows a correlation with both sAPPα and sAPPβ. β-Amyloid (1-43)(human) could be considered an added Alzheimer's disease (AD) biomarker together with the others already in use .

HY-176271

MAO-B-IN-45	Ferroptosis Monoamine Oxidase Glutathione Peroxidase Reactive Oxygen Species (ROS) Tau Protein Amyloid-β	Neurological Disease
MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. MAO-B-IN-45 shows selectivity towards MAO-B with an IC₅₀ of 87.47 nM and selectivity exceeding 229-fold for MAO-B over MAO-A. MAO-B-IN-45 has excellent antiferroptosis activity through modulation of the iron metabolic pathway and GSH-GPX4 axis in vitro. MAO-B-IN-45 improves cognitive and behavioral impairments in 3×Tg (APP/Tau/Ps1) AD mouse and significantly reduced the levels of ferritin heavy chain 1 (FTH1), APP, and Tau phosphorylation (p-Tau) proteins in the brain.

HY-P3779

Amyloid 17-42 Aβ(17-42)	Apoptosis	Neurological Disease
Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway .

HY-18010

PCI 29732 3 Publications Verification	Btk BCRP	Inflammation/Immunology
PCI 29732 is a potent, orally active, reversible BTK inhibitor with K_i ^app values of 8.2, 4.6, and 2.5 nM for BTK, Lck and Lyn, respectively. PCI 29732 shows only modest inhibitory activity against Itk, another Tec family kinase. PCI 29732 inhibits the function of ABCG2 by competitively binding to the ATP-binding site of ABCG2 .

HY-177646A

Mivelsiran sodium ALN-APP sodium	Amyloid-β	Neurological Disease
Mivelsiran sodium is a siRNA targeted to amyloid-beta precursor protein (APP). It is used for the study of Alzheimer's disease.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0192

Arbutin 3 Publications Verification β-Arbutin	Bergenia purpurascens (Hook. f. et Thoms.) Engl. Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Phenols Saxifragaceae Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Tyrosinase Endogenous Metabolite
Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with K_i ^app values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents . Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties .

HY-N1472

Levistolide A 5 Publications Verification	Natural Products Classification of Application Fields Dicerothamnus rhinocerotis Umbelliferae Plants Disease Research Fields Source Classification Cancer	Apoptosis Reactive Oxygen Species (ROS) PPAR GSK-3 Tau Protein Ras TGF-β Receptor
Levistolide A is an apoptosis inducer and a PEDV virus inhibitor. Levistolide A can induce apoptosis in colon cancer cells and suppress the replication of porcine epidemic diarrhea virus (PEDV) by promoting ROS generation. Levistolide A activates peroxisome proliferator-activated receptor γ (PPARγ) in N2a/APP695swe cells and reduces excessive phosphorylation of tau through the GSK3α/β pathway, improving symptoms in Alzheimer’s mice. Levistolide A improves kidney damage in 5/6 nephrectomy (Nx) mice by inhibiting the RAS,TGF-β1/Smad, and MAPK pathways .

HY-N3001

Isolinderalactone 1 Publications Verification	Classification of Application Fields Terpenoids Sesquiterpenes Plants Lauraceae Lindera aggregata (Sims) Kosterm. Disease Research Fields Source Classification Cancer	STAT VEGFR Bcl-2 Family Survivin IAP NF-κB Apoptosis Caspase
Isolinderalactone is a sesquiterpene that exhibits anti-cancer, anti-inflammatory, and neuroprotective effects. Isolinderalactone inhibits VEGF expression and tyrosine phosphorylation of VEGFR2. Isolinderalactone decreases viability and induces apoptosis in U-87 glioblastoma (GBM) cells and colorectal cancer (CRC) cells. Isolinderalactone induces G2/M phase cell cycle arrest, ROS generation, pJNK/p38 MAPK activation, in colorectal cancer (CRC) cells. Isolinderalactone blocks LPS (HY-D1056)-induced NF-κB activation while activating Nrf2-HMOX1 signaling in RAW264.7 macrophages. Isolinderalactone improves cognitive dysfunction in APP/PS1 mice. Isolinderalactone can be used for the study of Glioblastoma multiforme (GBM), colorectal cancer, Alzheimer’s disease and acute lung injury .

HY-107164

Thiomarinol A 4-Hydroxythiomarinol C	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial
Thiomarinol A (4-Hydroxythiomarinol C) is a potent antibiotic. Thiomarinol A is a hybrid of dithiolopyrrolone and marinolic acid. Thiomarinol A shows antimicrobial activity. Thiomarinol A inhibits MRSA IleRS in a dose-dependent with a K_i ^app value of 19 nM .

HY-108966

Kushenol C	Flavonols Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology Source Classification	Beta-secretase
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits *BACE1 (β-site APP* cleaving enzyme 1) with an IC₅₀** of 5.45 µM .

HY-N1414A

3′,6-Disinapoylsucrose 2 Publications Verification	Natural Products Polymer products Plants Brassicaceae Raphanus sativus Linn.	Bcl-2 Family Apoptosis
3′,6-Disinapoylsucrose is a type of oligosaccharide that's effective when taken orally, and it has antidepressant, anti-anxiety, and antioxidant properties. 3′,6-Disinapoylsucrose inhibits neuronal apoptosis by lowering the ratio of Bax to Bcl-2 in hippocampal neurons, and it enhances cognitive function in APP/PS1 transgenic mice by activating the CREB/BDNF signaling pathway .

HY-N12249

7-Deoxy-trans-dihydronarciclasine	Hosta plantaginea (Lam.) Aschers. Alkaloids Quinoline Alkaloids Plants Source Classification Asparagaceae Juss.	Amyloid-β TMV
7-Deoxy-trans-dihydronarciclasine, an alkaloid, is a tobacco mosaic virus (TMV) inhibitor (IC₅₀: 1.80 μM). 7-Deoxy-trans-dihydronarciclasine is an anti-neuroinflammatory agent. 7-Deoxy-trans-dihydronarciclasine decreases the Aβ and *APP* levels in the cerebral cortex of Tg2576 mice .

HY-129133

cis-Miyabenol C	Vitis vinifera cv. Zalema Phenols Plants Vitaceae Source Classification	Drug Isomer
cis-Miyabenol C is an isomer of the resveratrol trimer Miyabenol C, which can be isolated from grape herbs. Miyabenol C is an inhibitor of β-amyloid (Aβ) and amyloid β precursor protein (APP) in Alzheimer's disease model mice, and inhibit β-secretase activity without changing the protein level of β-secretase BACE1 .

HY-N13064

2,2′,4,4′-Tetrahydroxychalcone	Structural Classification Phenols Polyphenols Morus alba L. Plants Moraceae Source Classification	Drug Derivative Beta-secretase Amyloid-β
2,2′,4,4′-Tetrahydroxychalcone (Compound 18) is a selective and potent BACE1 inhibitor with an IC₅₀ of 0.62 μM. 2,2′,4,4′-Tetrahydroxychalcone is a derivative of Isoliquiritigenin (HY-N0102) found in Glycyrrhiza uralensis. 2,2′,4,4′-Tetrahydroxychalcone can block the β-cutting step of amyloid precursor protein (APP), thereby reducing the production of β-amyloid (Aβ) peptide. 2,2′,4,4′-Tetrahydroxychalcone can be used for research of Alzheimer’s disease .

Cat. No.	Product Name	Chemical Structure

HY-126242S

Tyk2-IN-7

Tyk2-IN-7 is an orally active TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC₅₀ and K_i.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 can inhibit the IL-23 and IFN-α signaling pathways. Tyk2-IN-7 is commonly used in the study of inflammatory conditions such as colitis .

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