1 Result for "

ASIC1a antagonist-1

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "ASIC1a antagonist-1" in MCE Product Catalog:

Cat. No.: HY-176550
CAS No.: 1787243-08-6
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

ASIC1a antagonist-1 (Compound 5b) is an orthosteric noncompetitive Acid sensing ion channels 1a (ASIC1a) antagonist with an IC50 of 27 nM (pH 6.7). ASIC1a antagonist-1 shifts pH dependence of ASIC1a activation and inhibits its maximal evoked response. ASIC1a antagonist-1 completely inhibits long-term potentiation (LTP) induction in CA3-CA1 pathway. ASIC1a antagonist-1 can be used for brain diseases and pathologies research [1].
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