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Antifibrinolytic activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (2) Bacterial (1) Endogenous Metabolite (1) Isotope-Labeled Compounds (1) MMP (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Infection (1) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-B1258

4-(Aminomethyl)benzoic acid 1 Publications Verification Aminomethylbenzoic acid; α-Amino-p-toluic acid	Amino Acid Derivatives	Cancer
4-(Aminomethyl)benzoic acid is a competitive inhibitor of PepT1 and has antifibrinolytic activity .

HY-117464

CM-352	MMP	Cardiovascular Disease
CM-352 (compound 5) is an inhibitor of matrix metalloproteinases (MMPs) (MMP-3: IC₅₀=15 nM; MMP-10: IC₅₀=12 nM). CM-352 has significant antifibrinolytic activity (EC₅₀=0.7 nM) and can significantly prolong blood coagulation time. CM-352 can be used in anti-bleeding research .

HY-B1258S

Intermediate of tranexamic Acid-13C2,15N Aminomethylbenzoic acid-¹³C₂,¹⁵N_{; α-Amino-p-toluic acid-¹³C₂,¹⁵N}	Isotope-Labeled Compounds Amino Acid Derivatives	Cancer
Intermediate of tranexamic Acid- ¹³C₂, ¹⁵N (Aminomethylbenzoic acid- ¹³C₂, ¹⁵N) is ¹³C and ¹⁵N labeled 4-(Aminomethyl)benzoic acid. 4-(Aminomethyl)benzoic acid is a competitive inhibitor of PepT1 and has antifibrinolytic activity .

HY-167934

Isomer-CM 352	Endogenous Metabolite	Neurological Disease
Isomer-CM 352 is a new antifibrinolytic agent with inhibitory activity against matrix metalloproteinases. Isomer-CM 352 effectively reduced hematoma expansion and promoted functional and neurological recovery in a model of intracerebral hemorrhage. Isomer-CM 352 improved neurological function by preventing hematoma growth and showed potential in the suppression of acute neurological diseases .

HY-180734

Beta-alanyl-L-lysine	Bacterial	Infection
Beta-alanyl-L-lysine, a L-lysine dipeptide, is an endogenous metabolite found in tibetan sheep . Beta-alanyl-L-lysine (compound 2) shows antistaphylococcal and antifibrinolytic activities .

Art. -Nr.	Produktname	Category	Target	Chemical Structure

HY-180734

Beta-alanyl-L-lysine	Structural Classification Amino acids Endogenous metabolite Source Classification	Bacterial
Beta-alanyl-L-lysine, a L-lysine dipeptide, is an endogenous metabolite found in tibetan sheep . Beta-alanyl-L-lysine (compound 2) shows antistaphylococcal and antifibrinolytic activities .

Art. -Nr.	Produktname	Chemical Structure

HY-B1258S

Intermediate of tranexamic Acid-13C2,15N
Intermediate of tranexamic Acid- ¹³C₂, ¹⁵N (Aminomethylbenzoic acid- ¹³C₂, ¹⁵N) is ¹³C and ¹⁵N labeled 4-(Aminomethyl)benzoic acid. 4-(Aminomethyl)benzoic acid is a competitive inhibitor of PepT1 and has antifibrinolytic activity .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Antifibrinolytic activity

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products