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No matches for "

BRL 42359

" within the MedChemExpress (MCE) catalog. Here are the results you might be looking for.

10

Inhibitors & Agonists

2

Recombinant Proteins

12

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-153356
    MRT-2359

    		Molecular Glues Apoptosis Inflammation/Immunology Cancer
    MRT-2359 is an orally active and selective GSPT1 molecular glue degrader, with a DC50 of 5 nM. MRT-2359 induces CRBN/GSPT1 ternary complex formation to drive CRBN- and degron-dependent proteasomal GSPT1 degradation, with selectivity for wild-type GSPT1 over the GSPT1G575N mutant. MRT-2359 disrupts protein translation, induces ribosome stalling, downregulates MYC family proteins and their transcriptional output, reduces proliferation, and induces apoptosis in cancer cells. MRT-2359 can be used for the research of non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), neuroendocrine lung cancer, high grade neuroendocrine cancers, diffuse large B-cell lymphoma, prostate cancer, and MYC-driven solid tumors .
    MRT-2359
  • HY-12192
    A-423579

    		Histamine Receptor Metabolic Disease
    A-423579 is an orally active non-imidazole histamine H3 receptor antagonist. A-423579 exhibits high affinity and good selectivity for human and rat H3 receptors, and possesses both antagonistic and inverse agonistic activities. A-423579 can effectively reduce body weight in obese rodents, with concomitant decreases in fat content, plasma leptin levels, and triglycerides. A-423579 possesses anti-obesity activity and can be used in the research of obesity and related metabolic disorders .
    A-423579
  • HY-106975
    SCH-42354

    		Neprilysin Cardiovascular Disease
    SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the proagent SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity .
    SCH-42354
  • HY-44132A
    Dehydro Palonosetron hydrochloride

    RS 42358-197 hydrochloride

    		 5-HT Receptor Cancer
    Dehydro Palonosetron hydrochloride (RS 42358-197 hydrochloride) is a 5-HT3 receptor antagonist. Dehydro Palonosetron hydrochloride has an antiemetic effect .
    Dehydro Palonosetron hydrochloride
  • HY-44132
    Dehydro Palonosetron

    RS 42358-197

    		 5-HT Receptor Neurological Disease
    Dehydro Palonosetron (RS 42358-197) is a potent, seslective and orally active 5-HT3 receptor antagonist. Dehydro Palonosetron has no effect on the activities of 5-HT1 receptors, 5-HT2 receptors or 5-HT4 receptors .
    Dehydro Palonosetron
  • HY-RI00938
    hsa-miR-4259 inhibitor

    		MicroRNA Cancer
    hsa-miR-4259 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    hsa-miR-4259 inhibitor
    hsa-miR-4259 inhibitor
  • HY-R00938A
    hsa-miR-4259 agomir

    		MicroRNA Cancer
    hsa-miR-4259 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-4259 agomir
    hsa-miR-4259 agomir
  • HY-R00938
    hsa-miR-4259 mimic

    		MicroRNA Cancer
    hsa-miR-4259 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    hsa-miR-4259 mimic
    hsa-miR-4259 mimic
  • HY-44132AR
    Dehydro Palonosetron hydrochloride (Standard)

    RS 42358-197 hydrochloride (Standard)

    		 Reference Standards 5-HT Receptor Cancer
    Dehydro Palonosetron (hydrochloride) (Standard) is the analytical standard of Dehydro Palonosetron (hydrochloride). This product is intended for research and analytical applications. Dehydro Palonosetron hydrochloride (RS 42358-197 hydrochloride) is a 5-HT3 receptor antagonist. Dehydro Palonosetron hydrochloride has an antiemetic effect .
    Dehydro Palonosetron hydrochloride (Standard)
  • HY-RI00938A
    hsa-miR-4259 antagomir

    		MicroRNA Cancer
    hsa-miR-4259 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-4259 antagomir
    hsa-miR-4259 antagomir

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