Frizzled 5 Antibody (YA4239)
(Synonyms: HFZ5; C2orf31; MGC129692; DKFZp434E2135)Frizzled 5 Antibody (YA4239) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Frizzled 5.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:400 | 1:10000 |
Product Details
Frizzled 5 Antibody (YA4239) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Frizzled 5.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 65-70 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 65 kDa
Purified recombinant fragment of human FZD5 (AA:151-217) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Frizzled 5 receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling. In neurons, activation by WNT7A promotes formation of synapses. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization. Plays a role in ocular development[1][2][3][4].
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Subcellular Localization
Cell membrane; Multi-pass membrane protein; Golgi apparatus membrane; Multi-pass membrane protein; Synapse; Perikaryon; Cell projection, dendrite; Cell projection, axon
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Subunit
Binding of unsaturated fatty acid molecules (via FZ domain) promotes homodimerization (PubMed:28377511). Interacts with WNT2B (PubMed:12490564). Interacts with WNT3A (PubMed:26908622).
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SwissProt ID
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Synonyms
HFZ5; C2orf31; MGC129692; DKFZp434E2135
Documentation
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