FZD5 - frizzled class receptor 5 Gene

Also Known as HFZ5; C2orf31

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7855

About FZD5

Cytogenetic location: 2q33.3 Genomic coordinates (GRCh38): 2:207,762,598-207,769,906 (from NCBI)

This gene has 1 transcript (splice variant), 144 orthologues, 15 paralogues and is associated with 7 phenotypes. Broad expression in colon (RPKM 15.4), duodenum (RPKM 10.5) and 19 other tissues.

Summary

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008]

FZD5 Products (1)

mRNA	Protein	Name
NM_003468.4	NP_003459.2	frizzled-5 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Wnt receptor activity	IDA IDA: Inferred from direct assay	15459103	GOA
enables Wnt-protein binding	IDA IDA: Inferred from direct assay	26908622	GOA
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	12490564	GOA
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	18234671	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18838381	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19643732	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	18234671	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	22575959	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Spemann organizer formation	IDA IDA: Inferred from direct assay	9054360	GOA
involved in anterior/posterior axis specification, embryo	IDA IDA: Inferred from direct assay	9054360	GOA
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	11029007	GOA
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	9054360	GOA
involved in cellular response to molecule of bacterial origin	IDA IDA: Inferred from direct assay	16601243	GOA
involved in embryonic axis specification	IDA IDA: Inferred from direct assay	12121999	GOA
involved in eye development	IMP IMP: Inferred from mutant phenotype	26908622	GOA
involved in non-canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	26908622	GOA
involved in positive regulation of T cell cytokine production	IDA IDA: Inferred from direct assay	16601243	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12857724	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	10906785	GOA
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	16601243	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	19643732	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15459103	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD5 Protein Structure

Frizzled

0
100
200
300
400
500
585 a.a.

Protein Preferred Names	Protein Names
frizzled-5	Wnt receptor

FZD5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FZD5	Q13467	SCYL2	Homo sapiens	Q6P3W7	Pull Down	19643732
Cross	FZD5	Q13467	tcdB	Clostridium difficile	M4NKV9	Pull Down	29748286

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FZD5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74138	Frizzled-5 Protein, Human (HEK293, His)	Q13467 (A27-P167)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74139	Frizzled-5 Protein, Human (HEK293, Fc)	Q13467 (A27-P167)	≥ 95%, as determined by reducing SDS-PAGE.

FZD5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84542	Frizzled 5 Antibody (YA4239)	WB, FC, ELISA	Human
HY-P84542A	Frizzled 5 Antibody (YA4239)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Coloboma Of Macula	Coloboma Congenital Ocular Coloboma Microphthalmia, Isolated, With Coloboma Agenesis Of Macula Hereditary Macular Coloboma Ocular Coloboma Coloboma Of Eye Macular Coloboma Uveoretinal Coloboma
Coloboma, Ocular, Autosomal Dominant	Coloboma, Ocular Coloboma Of Iris, Choroid, And Retina Coi Coloboma, Uveoretinal COAD Ocular Coloboma Uveoretinal Coloboma Chronic Obstructive Airway Disease
Coloboma Of Eyelid	Eyelid Coloboma
Coloboma Of Eye Lens
Coloboma Of Optic Nerve	Morning Glory Disc Anomaly Coloboma Of Optic Disc Morning Glory Syndrome Ectasic Coloboma Coloboma Of Optic Papilla Congenital Coloboma Of The Optic Nerve Optic Nerve Coloboma Optic Nerve Head Pits, Bilateral Congenital Volubilis Syndrome COLON Coloboma Of Optic Disc, Unspecified Eye Congenital Coloboma Of Optic Disc Optic Disk Coloboma
Retinochoroidal Coloboma	Coloboma Of Choroid And Retina Retinal Coloboma Choroidal Coloboma Chorioretinal Coloboma
Coloboma Of Iris	Iris Coloboma Cleft Iris Congenital Coloboma Of Iris Notched Iris Coloboma Nos Coloboma Of Iris, Choroid And Retina Coloboma Of Eye Congenital Ocular Coloboma Ocular Coloboma
Microphthalmia, Syndromic 6	MCOPS6 Microphthalmia And Pituitary Anomalies Microphthalmia With Brain And Digit Anomalies Microphthalmia With Brain And Digit Developmental Anomalies Syndromic Microphthalmia Type 6 Syndromic Microphthalmia 6 Anophthalmia Clinical With Micrognathia Malformed Ears Digital Anomalies And Abnormal External Genitalia Bakrania-Ragge Syndrome Orofacial Cleft 11 Anophthalmia, Clinical, With Micrognathia, Malformed Ears, Digital Anomalies, And Abnormal External Genitalia Microphthalmia Syndromic 6 Microphthalmia, Syndromic, 6 Clinical Anophthalmia With Micrognathia, Malformed Ears, Digital Anomalies And Abnormal External Genitalia Microphthalmia Syndromic, Type 6
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Persistent Hyperplastic Primary Vitreous	Congenital Retinal Detachment Ncrna Disease Non-Syndromic Congenital Retinal Non-Attachment Pfvs Phpv Persistent Fetal Vasculature Syndrome
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Robinow Syndrome, Autosomal Recessive 1	Robinow Syndrome, Autosomal Recessive Autosomal Recessive Robinow Syndrome Covesdem Syndrome RRS1 Costovertebral Segmentation Defect-Mesomelia Syndrome Rrs Costovertebral Segmentation Defect With Mesomelia, Formerly Covesdem Syndrome, Formerly Costovertebral Segmentation Defect With Mesomelia Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly Robinow, Autosomal Recessive Syndrome, Type 1
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0836	Jervine		99.28%	Unkown
HY-D1474	WNT7A-IN-1 sodium	Inhibitor	98.05%	Unkown
HY-170411	WNT7A-IN-1	Inhibitor	99.66%	Unkown
HY-RS05181	FZD5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N0836A	Jervine hydriodide		/	Unkown
HY-RS18360	Fzd5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24839	Fzd5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992229	Anti-FZD5 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FZD5	RGD	RGD:631406
Mus musculus	FZD5	MGD	MGI:108571
Felis catus	FZD5	VGNC	VGNC:107547
Canis familiaris	FZD5	VGNC	VGNC:41033
Macaca mulatta	FZD5	VGNC	VGNC:104530
Bos taurus	FZD5	VGNC	VGNC:29169
Others	FZD5	NCBI