461045-17-0
Chemical Structure
A-423579
- CAS No.: 461045-17-0
- Formula:C22H25F2N3O
- Molecular Weight:385.45
IUPAC Name: (R)-4'-(3-(3-(dimethylamino)pyrrolidin-1-yl)propoxy)-3',5'-difluoro-[1,1'-biphenyl]-4-carbonitrile
InChIKey: DJXFZKXYKKBTDR-LJQANCHMSA-N
SMILES: CN([C@@H]1CCN(CCCOC2=C(F)C=C(C3=CC=C(C#N)C=C3)C=C2F)C1)C
Biological Activity: A-423579 is an orally active non-imidazole histamine H3 receptor antagonist. A-423579 exhibits high affinity and good selectivity for human and rat H3 receptors, and possesses both antagonistic and inverse agonistic activities. A-423579 can effectively reduce body weight in obese rodents, with concomitant decreases in fat content, plasma leptin levels, and triglycerides. A-423579 possesses anti-obesity activity and can be used in the research of obesity and related metabolic disorders[1][2].
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A-423579 | A-423579 is an orally active non-imidazole histamine H3 receptor antagonist. A-423579 exhibits high affinity and good selectivity for human and rat H3 receptors, and possesses both antagonistic and inverse agonistic activities. A-423579 can effectively reduce body weight in obese rodents, with concomitant decreases in fat content, plasma leptin levels, and triglycerides. A-423579 possesses anti-obesity activity and can be used in the research of obesity and related metabolic disorders. | |||||||||||||||||||||
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- [1]. Hancock AA, et al. Antiobesity evaluation of histamine H3 receptor (H3R) antagonist analogs of A-331440 with improved safety and efficacy. Inflamm Res. 2005 Apr;54 Suppl 1:S27-9. [Content Brief]
- [2]. Masaki T, et al. Therapeutic approach of histamine H3 receptors in obesity. Recent Pat CNS Drug Discov. 2007 Nov;2(3):238-40. [Content Brief]
Keywords
