1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor
  3. Dehydro Palonosetron

Dehydro Palonosetron  (Synonyms: RS 42358-197)

Cat. No.: HY-44132
Handling Instructions

Dehydro Palonosetron (RS 42358-197) is a potent, seslective and orally active 5-HT3 receptor antagonist. Dehydro Palonosetron has no effect on the activities of 5-HT1 receptors, 5-HT2 receptors or 5-HT4 receptors.

For research use only. We do not sell to patients.

Dehydro Palonosetron Chemical Structure

Dehydro Palonosetron Chemical Structure

CAS No. : 135729-56-5

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Description

Dehydro Palonosetron (RS 42358-197) is a potent, seslective and orally active 5-HT3 receptor antagonist. Dehydro Palonosetron has no effect on the activities of 5-HT1 receptors, 5-HT2 receptors or 5-HT4 receptors[1].

IC50 & Target[1]

5-HT3 Receptor

 

In Vitro

In functional experiments in vitro, Dehydro Palonosetron (RS 42358-197) behaves as a competitive antagonist against 5-HT-induced contractions in the guinea pig ileum, yielding a pA2 estimate of 8.1. Dehydro Palonosetron is devoid of any agonistic or antagonistic activity at 5-HT1-like receptors, 5-HT2 receptors or 5-HT4 receptors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In anesthetized rats, Dehydro Palonosetron (RS 42358-197), administered by the intravenous, intraduodenal or transdermal route, dose-dependently inhibited the Bezold-Jarisch reflex induced by 2-methyl 5-HT (ID50:0.05 μg/kg; i.v., 5.7 μg/kg; i.d., and 11.6 μg/chamber, respectively)[1].
Dehydro Palonosetron (RS 42358-197; 0.01 ng/kg-10 mg/kg; oral administration; once) disinhibits behaviour in the mouse suppressed by the aversive situation of the light/dark test box[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male albino BKW mice (30-35 g)[2]
Dosage: 0.01 ng/kg, 0.1 ng/kg, 1 ng/kg, 100 ng/kg, 1 μg/kg, 100 μg/kg, 1 mg/kg, 10 mg/kg
Administration: Oral administration; once
Result: Increased the proportion of time mice spent and the number of rearings and line crossings in the light area of the test chamber.
Molecular Weight

294.39

Formula

C19H22N2O

CAS No.
SMILES

O=C1N([C@@H]2CN3CCC2CC3)C=C4C5=C1C=CC=C5CCC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Dehydro Palonosetron Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Dehydro Palonosetron
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HY-44132
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