Dehydro Palonosetron
Dehydro Palonosetron (RS 42358-197) is a potent, seslective and orally active 5-HT3 receptor antagonist. Dehydro Palonosetron has no effect on the activities of 5-HT1 receptors, 5-HT2 receptors or 5-HT4 receptors.
For research use only. We do not sell to patients.
- CAS No.: 135729-56-5
- Formula: C19H22N2O
- Molecular Weight:294.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
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5-HT3 Receptor |
In functional experiments in vitro, Dehydro Palonosetron (RS 42358-197) behaves as a competitive antagonist against 5-HT-induced contractions in the guinea pig ileum, yielding a pA2 estimate of 8.1. Dehydro Palonosetron is devoid of any agonistic or antagonistic activity at 5-HT1-like receptors, 5-HT2 receptors or 5-HT4 receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Dehydro Palonosetron (RS 42358-197; 0.01 ng/kg-10 mg/kg; oral administration; once) disinhibits behaviour in the mouse suppressed by the aversive situation of the light/dark test box[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male albino BKW mice (30-35 g)[2]
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Dosage:0.01 ng/kg, 0.1 ng/kg, 1 ng/kg, 100 ng/kg, 1 μg/kg, 100 μg/kg, 1 mg/kg, 10 mg/kg
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Administration:Oral administration; once
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Result:Increased the proportion of time mice spent and the number of rearings and line crossings in the light area of the test chamber.
Chemical Information
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CAS No. 135729-56-5
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Molecular Weight 294.39
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Formula C19H22N2O
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SMILES
O=C1N([C@@H]2CN3CCC2CC3)C=C4C5=C1C=CC=C5CCC4
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Synonyms
RS 42358-197
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. R M Eglen, et al. RS 42358-197, a novel and potent 5-HT3 receptor antagonist, in vitro and in vivo. J Pharmacol Exp Ther. 1993 Aug;266(2):535-43. [Content Brief]
[2]. B Costall, et al. The effect of the 5-HT3 receptor antagonist, RS-42358-197, in animal models of anxiety. Eur J Pharmacol. 1993 Mar 30;234(1):91-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dehydro Palonosetron Related Classifications
HY-44132 Related Classifications
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