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BSJ-04-146

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-179512
    BSJ-04-146

    		PROTACs FAK Cancer
    BSJ-04-146 is a highly efficient and selective PROTAC targeting focal adhesion kinase (FAK) inhibitor(IC50 = 26 nM). BSJ-04-146 achieves rapid and potent FAK degradation with high proteome-wide specificity in cancer cells and induces durable degradation in mice. BSJ-04-146 binds FAK and requires the ubiquitin-proteasome machinery to achieve FAK degradation. BSJ-04-146 can be used for the study of pancreatic cancer and triple-negative breast cancer .
    BSJ-04-146
  • HY-151010
    FAK ligand-2

    		Ligands for Target Protein for PROTAC FAK Cancer
    FAK ligand-2 is a FAK ligand and a ligand for the target protein of PROTAC (FAK). FAK ligand-2 can be used to synthesize BSJ-04-146 (HY-179512) .
    FAK ligand-2
  • HY-179515
    FAK ligand-2-C6-amine

    		Target Protein Ligand-Linker Conjugates Cancer
    FAK ligand-2-C6-amine is a target protein ligand linker conjugate that contains a FAK ligand (HY-151010) and a PROTAC linker (HY-W011561), which can recruit E3 ligases. FAK ligand-2-C6-amine can be used for synthesis of BSJ-04-146 (HY-179512) .
    FAK ligand-2-C6-amine

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