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Isoforms Recommended:	Bcl-xL

Results for "

Bcl-xL

" in MedChemExpress (MCE) Product Catalog:

標的別:	Bcl-2 Family (119) Akt (9) Amylases (1) Androgen Receptor (1) Apoptosis (85) Atg7 (1) Atg8/LC3 (1) Autophagy (18) Beta-lactamase (2) Biochemical Assay Reagents (3) c-Myc (1) Cadherin (2) Caspase (19) CDK (4) COX (3) DNA/RNA Synthesis (1) Drug Derivative (1) Drug Intermediate (1) E1/E2/E3 Enzyme (1) E3 Ligase Ligand-Linker Conjugates (7) Endogenous Metabolite (5) Environmental Pollutants (1) ERK (6) Eukaryotic Initiation Factor (eIF) (1) FAK (2) Fatty Acid Synthase (FASN) (3) FLT3 (2) Fungal (1) HDAC (4) IAP (1) Interleukin Related (1) Isotope-Labeled Compounds (3) JNK (6) Ligands for E3 Ligase (2) Ligands for Target Protein for PROTAC (5) MAP4K (1) MDM-2/p53 (5) MEK (2) Microtubule/Tubulin (7) Mitochondrial Metabolism (4) Mitophagy (1) MMP (3) mTOR (2) NF-κB (2) NO Synthase (1) P-glycoprotein (2) p38 MAPK (7) PARP (11) PDHK (2) Phosphatase (1) Phosphodiesterase (PDE) (1) PI3K (8) PIKfyve (1) PKC (4) PPAR (3) PROTAC Linkers (1) PROTACs (13) Protease Activated Receptor (PAR) (1) Raf (2) RAR/RXR (2) Reactive Oxygen Species (ROS) (9) Reference Standards (13) ROS Kinase (1) Small Interfering RNA (siRNA) (2) SRPK (1) STAT (7) Survivin (4) Thrombopoietin Receptor (2) TNF Receptor (1) TRP Channel (3) VEGFR (4) Virus Protease (1) WDR5 (2) β-catenin (1)
研究分野別:	Cancer (149) Cardiovascular Disease (5) Endocrinology (1) Infection (4) Inflammation/Immunology (27) Metabolic Disease (12) Neurological Disease (12)
クリックケミストリー:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) siRNAs (2)

167

阻害剤およびアゴニスト

生化学アッセイ試薬

ペプチド

阻害性抗体

天然物

組換えタンパク質

同位体標識化合物

抗体

クリックケミストリー

オリゴヌクレオチド

Targets Recommended: Bcl-2 Family BCL6

製品番号	製品名	Target	研究分野	構造式

HY-10087

Navitoclax 145+ Cited Publications ABT-263	Bcl-2 Family	Cancer
Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-x_L, Bcl-2 and Bcl-w, with a K_i of less than 1 nM .

HY-B0011

Docetaxel Maximum Cited Publications 158 Publications Verification RP-56976	Microtubule/Tubulin Apoptosis Endogenous Metabolite	Cancer
Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and *bcl-xL* gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-19741

A-1331852 50+ Cited Publications	Bcl-2 Family	Cancer
A-1331852 is an orally available *BCL-XL* selective inhibitor with a K_i of less than 10 pM.

HY-130604

DT2216 2 Publications Verification	Bcl-2 Family PROTACs Apoptosis	Cancer
DT2216 is a potent and selective *BCL-XL* (Bcl-2 family member) degrader based on PROTAC technology. DT2216 causes effective degradation of BCL-XL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets. DT2216 is composed of the Bcl-2 family protein inhibitor Navitoclax-piperazine (HY-44432), a linker, and a VHL E3 ubiquitin ligase (Pink: Navitoclax-piperazine; Blue: VHL ligand; Black: linker) .

HY-13407

Gossypol 5+ Cited Publications BL 193	Bcl-2 Family	Cancer
Gossypol binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-12048

Chelerythrine chloride 15+ Cited Publications	PKC Bcl-2 Family Apoptosis Autophagy	Metabolic Disease Inflammation/Immunology Cancer
Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC₅₀ of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.

HY-17510

Gossypol (acetic acid) 5+ Cited Publications (±)-Gossypol-acetic acid; BL-193 (acetic acid)	Bcl-2 Family	Cancer
Gossypol acetic acid ((±)-Gossypol-acetic acid) binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-19725

A-1155463 20+ Cited Publications	Bcl-2 Family	Cancer
A-1155463, a chemical probe, is a highly potent and selective *BCL-XL* inhibitor with an EC₅₀ of 70 nM in Molt-4 cell. A-1155463 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N2897

Dihydrokaempferol 5+ Cited Publications	Apoptosis Bcl-2 Family	Inflammation/Immunology
Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic agents .

HY-129179

Lisaftoclax 1 Publications Verification APG-2575; Bcl-2/Bcl-xL inhibitor 1	Bcl-2 Family	Cancer
Lisaftoclax (compound 6) is a dual *Bcl-2* and *Bcl-xl* inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Lisaftoclax exhibits IC₅₀ values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively .

HY-15607A

WEHI-539 hydrochloride 25+ Cited Publications	Bcl-2 Family	Cancer
WEHI-539 hydrochloride is a selective inhibitor of *Bcl-XL* with an IC₅₀ of 1.1 nM.

HY-15191

Sabutoclax 1 Publications Verification BI-97C1	Bcl-2 Family	Cancer
Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC₅₀s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively. Sabutoclax increases Bax, Bim, PUMA and survivin expression .

HY-44432

Navitoclax-piperazine ABT-263-piperazine	Ligands for Target Protein for PROTAC Bcl-2 Family	Cancer
Navitoclax-piperazine (ABT-263-piperazine) is a Navitoclax (HY-10087) analog and *BCL-XL* inhibitor. Navitoclax-piperazine is the ligand for target protein of PROTAC DT2216 (HY-130604). Navitodax-pperaie and E3 ubiquitin ligase VHL ligand can be used to synthesize PROTAC DT2216 (HY-130604) .

HY-109185

Pelcitoclax 1 Publications Verification APG-1252	Bcl-2 Family Apoptosis	Cancer
Pelcitoclax (APG-1252) is a potent *Bcl-2/Bcl-xl* inhibitor with antineoplastic and pro-apoptotic effects .

HY-133799

Pomalidomide-C7-COOH	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-C7-COOH is a synthesized E3 ligase cereblon ligand-linker conjugate. Pomalidomide-C7-COOH is an intermediate for the synthesis of PROTAC BCL-XL degraders .

HY-150069

UBX1325	Bcl-2 Family Apoptosis	Metabolic Disease
UBX1325 is an *Bcl-xL* inhibitor that promotes apoptosis in senescent cells. UBX1325 is a potent anti-aging agent that can be used in studies of age-related eye diseases such as diabetic macular oedema (DME), age-related macular degeneration (AMD) and diabetic retinopathy (DR) .

HY-133557

XZ739 1 Publications Verification	PROTACs Bcl-2 Family Apoptosis	Cancer
XZ739, a Cereblon-dependent PROTAC *BCL-XL* (Bcl-2 family member) degrader with a DC₅₀ value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis .

HY-139309

*PROTAC Bcl-xL* degrader-2**	Bcl-2 Family PROTACs	Cancer
PROTAC Bcl-xL degrader-2 is a potent *Bcl-xL* (Bcl-2 family member) degrader based on von Hippel-Lindau ligand, with an IC₅₀ of 0.6 nM.

HY-132997

*PROTAC Bcl-xL* degrader-3**	PROTACs Bcl-2 Family	Cancer
PROTAC Bcl-xL degrader-3 is a potent PROTAC Bcl-xL degrader. PROTAC Bcl-xL degrader-3 forms ternary complexes with the VHL-complex and BCL-XL. PROTAC Bcl-xL degrader-3 can be used in research on acute lymphoblastic leukemia .

HY-12020

TW-37 4 Publications Verification	Bcl-2 Family	Cancer
TW-37 is a potent *Bcl-2* inhibitor with K_i values of 260, 290 and 1110 nM for Mcl-1, *Bcl-2* and *Bcl-xL*, respectively.

HY-15613

Maritoclax 5+ Cited Publications Marinopyrrole A	Bcl-2 Family	Cancer
Maritoclax (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor with an IC₅₀ value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC₅₀ > 80 μM).

HY-115718

PZ703b 4 Publications Verification	PROTACs Bcl-2 Family	Cancer
PZ703b is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b can be used for the research of bladder cancer research .

HY-12011

HA14-1 2 Publications Verification	Bcl-2 Family	Cancer
HA14-1 is a *Bcl-2/Bcl-X_L* antagonist. HA14-1 binds the designated pocket on Bcl-2 with the IC₅₀ of ≈9 μM in competing with the Bcl-2 binding of Flu-BakBH3, and inhibits its function.

HY-12908

Bcl-xL antagonist 2	Bcl-2 Family Apoptosis	Cancer
Bcl-xL antagonist 2 is a potent, selective, and orally active antagonist of *BCL-X_L* with an IC₅₀ and K_i of 0.091 μM and 65 nM, respectively. Bcl-xL antagonist 2 promotes the apoptosis of cancer cells. Bcl-xL antagonist 2 has the potential for the research of the chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL) .

HY-120882

BM-1197 UBX1967	Bcl-2 Family	Cancer
BM-1197 (UBX1967) is a potent and selective inhibitor of dual *Bcl-2/Bcl-xL, with IC₅₀s of 3.5 nM and 5.2 nM for Bcl-2 and Bcl-xL*, respectively. BM-1197 exhibits antitumor effects both in vitro and in vivo .

HY-16014

A-385358	Bcl-2 Family	Cancer
A-385358 is a selective inhibitor of *Bcl-X_L* with K_is of 0.80 and 67 nM for *Bcl-X_L* and *Bcl-2*, respectively.

HY-174876

PZ671	PROTACs Bcl-2 Family Apoptosis	Cancer
PZ671 is a potent Bcl-xL PROTAC degrader with an IC₅₀ of 1.3 nM (MOLT-4 cells) and a DC₅₀ of 0.9 nM (Bcl-xL). PZ671 induces apoptosis in MOLT-4 cells. PZ671 effectively inhibits tumor growth and rapidly reverses transient platelet counts reduction in MOLT-4 xenograft mice. PZ671 can be used for the research of cancer, such as small cell lung cancer (SCLC) . (Structure Note: Pink: Bcl-xL ligand (HY-174878); Blue: CRBN Ligand (HY-138793); Black: linker; E3-linker (HY-174879))

HY-161410

WH244	PROTACs Apoptosis Bcl-2 Family	Cancer
WH244 is a second generation *BCL-2* and *BCL-xL* dual depressant (PROTAC). The primary activity of WH244 is the specific degradation of *BCL-2* and *BCL-xL* proteins (BCL-xL: DC₅₀=0.6 nM, BCL-2: DC₅₀=7.4 nM). WH244 promotes their ubiquitination and subsequent proteasome degradation by targeting these proteins, thereby restoring the cell's apoptosis pathway. WH244 has good antitumor activity. (Pink: BCL-2/BCL-xL ligand (HY-161415); Blue: E3 ligase ligand (HY-112078); Black: linker) .

HY-15464

(R)-(-)-Gossypol 3 Publications Verification AT-101; R-(-)-gossypol acetic acid	Bcl-2 Family Autophagy	Cancer
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to *Bcl-2, Mcl-1* and *Bcl-xL* proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-15464A

(R)-(-)-Gossypol acetic acid 5+ Cited Publications AT-101 (acetic acid); (-)-Gossypol acetic acid; (R)-Gossypol acetic acid	Bcl-2 Family Autophagy	Cancer
(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to *Bcl-2, Mcl-1* and *Bcl-xL* proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-100383

BH3I-1 BHI1	Bcl-2 Family MDM-2/p53 E1/E2/E3 Enzyme	Cancer
BH3I-1 is a Bcl-2 family antagonist, which inhibits the binding of the Bak BH3 peptide to *Bcl-xL* with a K_i of 2.4±0.2 μM in FP assay. BH3I-1 has a K_d of 5.3 μM against the p53/MDM2 pair.

HY-138697

S65487 VOB560	Bcl-2 Family Apoptosis	Cancer
S65487 (VOB560), a potent and selective *BCL-2* inhibitor, is a proagent of S55746. S65487 is also active on BCL-2 mutations, such as G101V and D103Y. S65487 has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 induces apoptosis and has anticaner activities .

HY-B0011S

Docetaxel-d9 RP-56976-d₉	Microtubule/Tubulin Apoptosis Endogenous Metabolite	Cancer
Docetaxel-d₉ is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule?depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of?bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-P3560

Edratide TV 4710	Apoptosis	Inflammation/Immunology
Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. Edratide reduces the rates of apoptosis (Apoptosis) and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL. Edratide has the potential for the research of systemic lupus erythematosus (SLE) .

HY-15464D

(S)-Gossypol (acetic acid) 4 Publications Verification (S)-(+)-Gossypol acetic acid	Bcl-2 Family	Cancer
(S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of *Bcl-xL* and *Bcl-2* proteins with high affinity.

HY-139304

*PROTAC Bcl-xL* ligand-1**	Ligands for Target Protein for PROTAC Bcl-2 Family	Cancer
PROTAC Bcl-xL ligand-1 is a ligand for Bcl-xL that can be used in the synthesis of PROTACs .

HY-13408

(+)-Apogossypol Apogossypol; NSC736630	Bcl-2 Family	Cancer
(+)-Apogossypol is a *pan-BCL-2* antagonist. (+)-Apogossypol binds to Mcl-1, *Bcl-2* and *Bcl-xL* with EC₅₀s of 2.6, 2.8 and 3.69 µM, respectively.

HY-131188

*PROTAC Bcl-xL* degrader-1**	PROTACs Bcl-2 Family	Cancer
PROTAC Bcl-xL degrader-1 is a PROTAC that comprises a *Bcl-xL* (Bcl-2 family member) ligand binding group, a linker and an IAP E3 ligases binding group. PROTAC Bcl-xL degrader-1 is a potent *Bcl-xL* degrader, and shows toxicity for human platelets and MyLa 1929 cells with IC₅₀ values of 62 nM and 8.5 μM, respectively .

HY-10087R

Navitoclax (Standard) ABT-263 (Standard)	Reference Standards Bcl-2 Family	Cancer
Navitoclax (Standard) is the analytical standard of Navitoclax. This product is intended for research and analytical applications. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .

HY-B0011R

Docetaxel (Standard) RP-56976 (Standard)	Reference Standards Microtubule/Tubulin Apoptosis Endogenous Metabolite	Cancer
Docetaxel (Standard) is the analytical standard of Docetaxel. This product is intended for research and analytical applications. Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and *bcl-xL* gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-131232

Desmorpholinyl Navitoclax-NH-Me Desmorpholinyl ABT-263-NH-Me	Bcl-2 Family Ligands for Target Protein for PROTAC	Cancer
Desmorpholinyl Navitoclax-NH-Me is a *Bcl-xL* inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739 (HY-133557) .

HY-15607

WEHI-539	Bcl-2 Family	Cancer
WEHI-539 is a selective inhibitor of *Bcl-XL* with an IC₅₀ of 1.1 nM.

HY-19551

Apogossypolone ApoG2	Bcl-2 Family Apoptosis Autophagy Fungal ROS Kinase	Infection Cancer
Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with K_i values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-X_L, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis and autophagy . Apogossypolone also has antifungal activity .

HY-170406

BCL-XL-IN-3	Bcl-2 Family	Cancer
BCL-XL-IN-3 (Compound 11) is an inhibitor for *BCL-XL* with a K_i < 0.01 nM. BCL-XL-IN-3 inhibits the cell viability in normal Molt-4 and Digitonin (HY-N4000)-permeabilized Molt-4 with EC₅₀ of 77.8 nM and 0.07 nM. BCL-XL-IN-3 can be used as ADC toxin for synthesis of Clezutoclax (HY-137774) .

HY-P99119

Anti-Mouse 4-1BB/CD137 Antibody (3H3)	TNF Receptor Bcl-2 Family	Inflammation/Immunology Cancer
Anti-Mouse 4-1BB/CD137 Antibody (3H3) is an anti-mouse 4-1BB/CD137 IgG2a monoclonal antibody. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can effectively activate memory T cells and inhibit tumors by increasing *Bcl-xL* and granzyme B levels. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can be used for research on cancer such as lymphoma and colon cancer .

HY-P2343

BH3 hydrochloride	Apoptosis	Cancer
BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian .

HY-176740

*PROTAC Bcl-xL* degrader-4**	PROTACs Bcl-2 Family p38 MAPK Reactive Oxygen Species (ROS) Mitochondrial Metabolism Apoptosis ERK JNK	Cancer
PROTAC Bcl-xL degrader-4 (Compound 2-38-III) is a *Bcl-xL* PROTAC degrader. PROTAC Bcl-xL degrader-4 has strong anti-tumor activity against HepG2 cells and HUVEC cells. PROTAC Bcl-xL degrader-4 induces cells apoptosis by decreasing mitochondrial membrane potential and activating the MAPK signaling pathway. PROTAC Bcl-xL degrader-4 significantly inhibits tumor growth in xenograft tumor mouse models . Pink: MAPK ligand (HY-176741); Blue: CRBN ligase ligand (HY-10984); Black: linker (HY-W017440)

HY-174878

BCL-xL ligand 2	Ligands for Target Protein for PROTAC Bcl-2 Family	Cancer
BCL-xL ligand 2 is a ligand for BCL-xL. BCL-xL ligand 2 can be conjugated with E3 ligase Ligand (HY-138793) and linker to synthesize Bcl-xL PROTAC degrader PZ671 (HY-174876) .

HY-135275

BCL-XL-IN-4	Bcl-2 Family	Cancer
BCL-XL-IN-4 (compound 10) is a potent and selective *BCL-XL* inhibitor with K_i values of 0.042, 170 nM for BCL-XL, BCL-2, respectively. BCL-XL-IN-4 shows cytotoxicity .

HY-P2499A

BAD (103-127) (human), FAM-labeled TFA	Bcl-2 Family	Cancer
BAD (103-127) (human), FAM-labeled TFA is a FAM-labeled human BAD (103-127) (HY-P2468). BAD (103-127) (human) TFA, the 25-mer Bad peptide, is derived from the BH3 domain of BAD and can antagonize the function of *Bcl-xL* .

製品番号	製品名	Type

HY-159059

Ganoderma Lucidum/Reishi Extract

生化学アッセイ試薬

Ganoderma Lucidum/Reishi Extract is a Ganoderma lucidum extract. Ganoderma Lucidum/Reishi Extract reduces the expression of c-Myc, BCL-2, BCL-XL, TERT, PDGFB, eIF4G, Survivin, β-catenin, and eIF4E. Ganoderma Lucidum/Reishi Extract downregulates the gene expression of MMP-9. Ganoderma Lucidum/Reishi Extract upregulates the expression of IL8. Ganoderma Lucidum/Reishi Extract is applicable to the research of inflammatory breast cancer. Ganoderma Lucidum is used in the research of various diseases, such as allergy, arthritis, hypertension, neurasthenia, inflammation, and cancer .

HY-Y0396

N-Hydroxyphthalimide

生化学アッセイ試薬

N-Hydroxyphthalimide is a blocking agent and catalyst. N-Hydroxyphthalimide promotes oxidation reactions by generating PINO free radicals and activating hydrogen atom transfer processes. N-Hydroxyphthalimide reduces the expression of anti-apoptotic proteins Survivin and Bcl-xL and activates caspase 9 and caspase 3. N-Hydroxyphthalimide induces Apoptosis. N-Hydroxyphthalimide inhibits the phosphorylation of mTOR (Ser2448, Ser2481) and Akt (Ser473). N-Hydroxyphthalimide has anticancer effects against breast and colon cancer .

HY-Y0396R

N-Hydroxyphthalimide (Standard)

生化学アッセイ試薬

N-Hydroxyphthalimide (Standard) is the analytical standard of N-Hydroxyphthalimide (HY-Y0396). This product is intended for research and analytical applications. N-Hydroxyphthalimide is a blocking agent and catalyst. N-Hydroxyphthalimide promotes oxidation reactions by generating PINO free radicals and activating hydrogen atom transfer processes. N-Hydroxyphthalimide reduces the expression of anti-apoptotic proteins Survivin and Bcl-xL and activates caspase 9 and caspase 3. N-Hydroxyphthalimide induces Apoptosis. N-Hydroxyphthalimide inhibits the phosphorylation of mTOR (Ser2448, Ser2481) and Akt (Ser473). N-Hydroxyphthalimide has anticancer effects against breast and colon cancer .

製品番号	製品名	Target	研究分野

HY-P3560

Edratide TV 4710	Apoptosis	Inflammation/Immunology
Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. Edratide reduces the rates of apoptosis (Apoptosis) and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL. Edratide has the potential for the research of systemic lupus erythematosus (SLE) .

HY-P2343

BH3 hydrochloride	Apoptosis	Cancer
BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian .

HY-P2499A

BAD (103-127) (human), FAM-labeled TFA	Bcl-2 Family	Cancer
BAD (103-127) (human), FAM-labeled TFA is a FAM-labeled human BAD (103-127) (HY-P2468). BAD (103-127) (human) TFA, the 25-mer Bad peptide, is derived from the BH3 domain of BAD and can antagonize the function of *Bcl-xL* .

HY-P2468

BAD (103-127) (human) BADBH3 103-127 (human); BADBH3 (human)	Bcl-2 Family	Cancer
BAD (103-127) (human), the 25-mer Bad peptide, is derived from the BH3 domain of BAD, can antagonize the function of *Bcl-xL. BAD (103-127) (human) is reported to have almost 800-fold higher affinity for Bcl-XL* than the 16-mer peptide .

HY-P5320

*TAT-BH4 (Bcl-xL)*	Apoptosis	Others
TAT-BH4 (Bcl-xL) localized mainly at the mitochondria, prevents apoptotic cell death. TAT-BH4 (Bcl-xL) is a fusion peptide that combines the N-terminal cysteine conjugated protein transduction domain of HIV TAT protein (amino acids 49 to 57) with the Bcl-xL BH4 peptide. TAT-BH4 can be used for research of diseases caused by accelerated apoptosis .

HY-P0300

Bak BH3	Bcl-2 Family	Cancer
Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of *Bcl-xL* in cells.

HY-P5320A

*TAT-BH4 (Bcl-xL) TFA*	Apoptosis	Others
TAT-BH4 (Bcl-xL) TFA is localized mainly at the mitochondria, prevents apoptotic cell death. TAT-BH4 (Bcl-xL) is a fusion peptide that combines the N-terminal cysteine conjugated protein transduction domain of HIV TAT protein (amino acids 49 to 57) with the Bcl-xL BH4 peptide. TAT-BH4 TFA can be used for research of diseases caused by accelerated apoptosis .

HY-P2499

BAD (103-127) (human), FAM-labeled	Bcl-2 Family	Cancer
BAD (103-127) (human), FAM-labeled is a FAM-labeled human BAD (103-127) (HY-P2468). BAD (103-127) (human), the 25-mer Bad peptide, is derived from the BH3 domain of BAD and can antagonize the function of *Bcl-xL* .

製品番号	製品名	Target	研究分野	Image

HY-P99119

Anti-Mouse 4-1BB/CD137 Antibody (3H3)	TNF Receptor Bcl-2 Family	Inflammation/Immunology Cancer
Anti-Mouse 4-1BB/CD137 Antibody (3H3) is an anti-mouse 4-1BB/CD137 IgG2a monoclonal antibody. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can effectively activate memory T cells and inhibit tumors by increasing *Bcl-xL* and granzyme B levels. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can be used for research on cancer such as lymphoma and colon cancer .

製品番号	製品名	Category	Target	構造式

HY-B0011

Docetaxel Maximum Cited Publications 158 Publications Verification RP-56976	Structural Classification Classification of Application Fields Terpenoids Diterpenoids Endogenous metabolite Disease Research Fields Source Classification Cancer	Microtubule/Tubulin Apoptosis Endogenous Metabolite
Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and *bcl-xL* gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-15128

9-cis-Retinoic acid 5 Publications Verification Alitretinoin	Classification of Application Fields Terpenoids Diterpenoids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	RAR/RXR Apoptosis Endogenous Metabolite
9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities .

HY-13407

Gossypol 5+ Cited Publications BL 193	Malvaceae Classification of Application Fields Phenols Polyphenols Gossypium herbaceum Linn. Plants Disease Research Fields Source Classification Cancer	Bcl-2 Family
Gossypol binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-N0087

Gambogic Acid 5+ Cited Publications Beta-Guttiferrin	天然物 Classification of Application Fields Guttiferae Plants Garcinia hanburyi Hook. f. Disease Research Fields Cancer	Bcl-2 Family Autophagy
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits *Bcl-X_L, Bcl-2, Bcl-W, Bcl-B, Bfl-1* and Mcl-1 with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-12048

Chelerythrine chloride 15+ Cited Publications	Alkaloids Chelidonium majus Classification of Application Fields Metabolic Disease Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Papaveraceae Source Classification	PKC Bcl-2 Family Apoptosis Autophagy
Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC₅₀ of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.

HY-17510

Gossypol (acetic acid) 5+ Cited Publications (±)-Gossypol-acetic acid; BL-193 (acetic acid)	other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	Bcl-2 Family
Gossypol acetic acid ((±)-Gossypol-acetic acid) binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-N2897

Dihydrokaempferol 5+ Cited Publications	Flavanonols Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Bauhinia championii (Benth.) Benth. Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis Bcl-2 Family
Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic agents .

HY-N0361

Dihydrocapsaicin 4 Publications Verification	Alkaloids Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Other Alkaloids Phenols Metabolic Disease Solanaceae Plants Disease Research Fields Source Classification	Environmental Pollutants Caspase Akt Apoptosis Reactive Oxygen Species (ROS) TRP Channel Bcl-2 Family PI3K
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased *Bcl-2, Bcl-xL* and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-N0763

Angelicin 10+ Cited Publications Isopsoralen	Classification of Application Fields Leguminosae Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields Source Classification Cancer	Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase
Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like *Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9* and caspase-3.

HY-N1983

Caudatin 1 Publications Verification	Structural Classification Classification of Application Fields Asclepiadaceae Cynanchum otophyllum Schneid． Cynanchum auriculatum Royle ex Wight Plants Disease Research Fields Steroids Source Classification Cancer	Apoptosis Autophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism PARP Caspase Bcl-2 Family VEGFR FAK WDR5 p38 MAPK JNK PPAR
Caudatin is an orally active and brain-penetrant C-21 steroidal found in Cynanchum bungei decne with a variety of biological activities. Caudatin can inhibit cell proliferation, migration, invasion, cause cell phase arrest, induce apoptosis, autophagy, ROS prodution and loss of mitochondrial membrane potential. Caudatin activates PARP, caspase-3, -7, -9, upregulates pro-apoptotic Bad and Bax and downregulates anti-apoptotic *Bcl-2* and *Bcl-XL. Caudatin suppresses VEGF, FAK* phosphorylation, upregulates p21, p27, DR5 protein expression, activates the p38 MAPK, JNK and PPARα/TFEB-mediated autophagy-lysosomal signaling pathways. Caudatin can be used for the research of cancer, inflammation and neurological disease, such as glioma and Alzheimer's disease .

HY-N2359

Chelerythrine	Alkaloids Classification of Application Fields Metabolic Disease Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Papaveraceae Source Classification	Beta-lactamase PKC Bcl-2 Family Apoptosis Autophagy
Chelerythrine is a natural alkaloid, acts as a potent and selective Ca ²⁺/phospholopid-dependent PKC antagonist, with an IC₅₀ of 0.7 μM . Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity . Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy .

HY-N0894

Octahydrocurcumin 1 Publications Verification Hexahydrobisdemethoxycurcumin	Structural Classification Classification of Application Fields Other Diseases Phenols Polyphenols Plants Curcuma longa Disease Research Fields Source Classification Zingiberaceae	Apoptosis MAP4K NF-κB COX
Octahydrocurcumin (Hexahydrobisdemethoxycurcumin) is an orally active anticancer and anti-inflammatory agent, and is the final hydrogenated metabolite of Curcumin (HY-N0005) in vivo. Octahydrocurcumin exerts its anti-tumor and anti-inflammatory effects by inducing the mitochondrial apoptosis pathway and inhibiting the TAK1-NF-κB-COX-2 pathway, respectively .

HY-15464

(R)-(-)-Gossypol 3 Publications Verification AT-101; R-(-)-gossypol acetic acid	Malvaceae Classification of Application Fields Gossypium Phenols Plants Disease Research Fields Cancer Source Classification	Bcl-2 Family Autophagy
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to *Bcl-2, Mcl-1* and *Bcl-xL* proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-B0011R

Docetaxel (Standard) RP-56976 (Standard)	Structural Classification 天然物 Endogenous metabolite Source Classification	Reference Standards Microtubule/Tubulin Apoptosis Endogenous Metabolite
Docetaxel (Standard) is the analytical standard of Docetaxel. This product is intended for research and analytical applications. Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and *bcl-xL* gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-N16483

Procyanidin B2-3'-O-gallate	Structural Classification Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae Source Classification	Apoptosis Caspase Bcl-2 Family PARP Androgen Receptor
Procyanidin B2-3'-O-gallate is a mono-gallate ester that can be isolated from grape seed extract. Procyanidin B2-3'-O-gallate has anti-cancer efficacy and reduces the viability of prostate carcinoma LNCaP cells. Furthermore, Procyanidin B2-3'-O-gallate induces apoptosis, and causes caspases-9 and -3 and PARP cleavage, and down-regulates *Bcl-2, Bcl-Xl* and androgen receptor levels .

HY-N12999

Stigmast-5-en-3-ol	Cardiacglycosides Scrophulariaceae Scrophularia takesimensis Plants Lipid Steroids Source Classification	Apoptosis Bcl-2 Family Caspase MDM-2/p53 PARP Amylases
Stigmast-5-en-3-ol induces cancer cell apoptosis and inhibits proliferation by increasing the production of Bax, Caspase-9, p53, and PARP cleavage and reducing *Bcl-xl* expression. Stigmast-5-en-3-ol exhibits potent inhibitory activity against glucoamylase and α-amylase and possesses high antioxidant activity. Stigmast-5-en-3-ol can be used in the research of diseases such as leukemia, breast cancer, type 2 diabetes, and obesity .

HY-N6576

Hellebrigenin	Animals Classification of Application Fields Disease Research Fields Steroids Source Classification Cancer	p38 MAPK ERK JNK IAP PARP Apoptosis Caspase
Hellebrigenin is an inhibitor that selectively targets the MAPK signaling pathway (ERK, p38, JNK) and XIAP, and can inhibit Akt expression and phosphorylation. Hellebrigenin can activate endogenous apoptosis pathways (such as mitochondrial membrane potential disruption, Caspase family activation, PARP cleavage), downregulate anti-apoptotic proteins (Bcl-2, *Bcl-xL) and upregulate pro-apoptotic proteins (Bax, Bak). Hellebrigenin can also induce DNA double-strand breaks to activate the ATM* pathway. Hellebrigenin can inhibit tumor cell proliferation and clone formation, and is mainly used in the study of oral squamous cell carcinoma, liver cancer and other cancers .

HY-N1983R

Caudatin (Standard)	Structural Classification Asclepiadaceae Cynanchum otophyllum Schneid． Cynanchum auriculatum Royle ex Wight Plants Steroids Source Classification	Reference Standards Apoptosis Autophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism PARP Caspase Bcl-2 Family VEGFR FAK WDR5 p38 MAPK JNK PPAR
Caudatin (Standard) is the analytical standard of Caudatin (HY-N1983). This product is intended for research and analytical applications. Caudatin is an orally active and brain-penetrant C-21 steroidal found in Cynanchum bungei decne with a variety of biological activities. Caudatin can inhibit cell proliferation, migration, invasion, cause cell phase arrest, induce apoptosis, autophagy, ROS prodution and loss of mitochondrial membrane potential. Caudatin activates PARP, caspase-3, -7, -9, upregulates pro-apoptotic Bad and Bax and downregulates anti-apoptotic *Bcl-2* and *Bcl-XL. Caudatin suppresses VEGF, FAK* phosphorylation, upregulates p21, p27, DR5 protein expression, activates the p38 MAPK, JNK and PPARα/TFEB-mediated autophagy-lysosomal signaling pathways. Caudatin can be used for the research of cancer, inflammation and neurological disease, such as glioma and Alzheimer's disease .

HY-13407R

Gossypol (Standard) BL 193 (Standard)	Malvaceae Structural Classification Phenols Polyphenols Gossypium herbaceum Linn. Plants Source Classification	Reference Standards Bcl-2 Family
Gossypol (Standard) is the analytical standard of Gossypol. This product is intended for research and analytical applications. Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-17510R

Gossypol (acetic acid) (Standard) (±)-Gossypol-acetic acid (Standard); BL-193 (acetic acid) (Standard)	Structural Classification other families Phenols Polyphenols Plants Source Classification	Reference Standards Bcl-2 Family
Gossypol (acetic acid) (Standard) is the analytical standard of Gossypol (acetic acid). This product is intended for research and analytical applications. Gossypol acetic acid ((±)-Gossypol-acetic acid) binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-N0361R

Dihydrocapsaicin (Standard)	Alkaloids Structural Classification Monophenols Capsicum annuum L. Other Alkaloids Phenols Solanaceae Plants Source Classification	Reference Standards TRP Channel Reactive Oxygen Species (ROS) Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin (Standard) is the analytical standard of Dihydrocapsaicin. This product is intended for research and analytical applications. Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-N17676

3-Tridecylphenol	Structural Classification Monophenols Ginkgoaceae Phenols Plants Ginkgo biloba Source Classification	Bcl-2 Family
3-Tridecylphenol is a cardanol. 3-Tridecylphenol can be isolated from K. hookeriana. 3-Tridecylphenol shows K_i values of >23 μM and >33 μM in *BclxL/Bak* and Mcl-1/Bid displacement assays, respectively. 3-Tridecylphenol can be used in cancer research .

HY-12048R

Chelerythrine chloride (Standard)	Alkaloids Structural Classification Chelidonium majus Plants Isoquinoline Alkaloids Papaveraceae Source Classification	Reference Standards PKC Bcl-2 Family Apoptosis Autophagy
Chelerythrine (chloride) (Standard) is the analytical standard of Chelerythrine (chloride). This product is intended for research and analytical applications. Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC₅₀ of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.

HY-N2897R

Dihydrokaempferol (Standard)	Flavanonols Structural Classification Flavonoids Leguminosae Phenols Polyphenols Bauhinia championii (Benth.) Benth. Plants Source Classification	Reference Standards Apoptosis Bcl-2 Family
Dihydrokaempferol (Standard) is the analytical standard of Dihydrokaempferol. This product is intended for research and analytical applications. Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic agents .

HY-N0087R

Gambogic Acid (Standard) Beta-Guttiferrin (Standard)	Structural Classification 天然物 Guttiferae Plants Garcinia hanburyi Hook. f.	Reference Standards Bcl-2 Family Autophagy
Gambogic Acid (Standard) is the analytical standard of Gambogic Acid. This product is intended for research and analytical applications. Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-15128R

9-cis-Retinoic acid (Standard) Alitretinoin (Standard)	Structural Classification Terpenoids Diterpenoids Endogenous metabolite Source Classification	Reference Standards RAR/RXR Apoptosis Endogenous Metabolite
9-cis-Retinoic acid (Standard) is the analytical standard of 9-cis-Retinoic acid. This product is intended for research and analytical applications. 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities[1][2][3][4][5].

HY-N7917

Tenacigenoside A	Apocynaceae Structural Classification Tetracyclic Triterpenoids Terpenoids Plants Source Classification	P-glycoprotein Apoptosis Bcl-2 Family
Tenacigenoside A is a multidrug resistance reversal agent and apoptosis inducer that selectively acts on P-glycoprotein and apoptosis-related proteins (BCL2, *BCL-XL, BID*). Tenacigenoside A exerts its key activity by regulating the expression of apoptosis-related proteins and inhibiting P-gp function, thereby inhibiting tumor cell proliferation, inducing tumor cell apoptosis, and reversing multidrug resistance in tumors. Tenacigenoside A can be used in research on malignant tumors such as lymphoma .

HY-N9826

Icterogenin	Structural Classification Terpenoids Verbenaceae Plants Pentacyclic Triterpenoids Lantana camaraLinn. Source Classification	Bcl-2 Family
Icterogenin is a selective inhibitor targeting the Bcl-XL/Bak BH3 domain peptide interaction and exhibits anti-leukemic activity. Icterogenin regulates protein interactions and affects tumor cell survival. Icterogenin is an oleanane-type triterpenoid compound that can be isolated from Lantana camara and is useful in the field of anti-tumor drug development .

HY-N17617

S-Petasin	Structural Classification 天然物 Plants Petasites hybridus (L.) G.Gaertn., B.Mey. & Schreb. Compositae Source Classification	Phosphodiesterase (PDE) Apoptosis NO Synthase Caspase PPAR Bcl-2 Family PARP
S-Petasin is a phosphodiesterase (PDE) inhibitor with IC₅₀ values of 25.5 μM and 17.5 μM for PDE3 and PDE4, respectively. S-Petasin inhibits cholesterol side-chain cleavage enzyme, 11β-hydroxylase, PPAR-γ, and iNOS induction at RNA and protein levels. S-Petasin induces apoptosis, activates caspases, cleaves PARP, modulates mitochondrial membrane permeability, and regulates *BCL2/BAX*, p53, *Bcl-XL, MMP-2, MMP-9, p21, CDK4, and cyclin D1* expression. S-Petasin reduces inflammatory cell accumulation, cytokine and IgE levels, and enhances serum IgG2a levels. S-Petasin relaxes isolated sensitized guinea pig trachealis and exhibits gastrointestinal anti-spasmodic activity. S-Petasin reduces tonsillitis severity and asthmatic attack frequency. S-Petasin can be used for the research of prostate cancer, obesity, melanoma, allergic asthma, asthma, and peritonitis .

Species:	Human (1) Mouse (2)
Tag:	His (3)
Source:	E. coli (3)

製品番号	Compare	製品名	Species	Source	Image

HY-P72846

	Bcl-XL Protein, Mouse (His, solution) Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X; Bclx	Mouse	E. coli
	Bcl-XL protein forms heterodimers with BAX, BAK, or BCL2, but its antiapoptotic activity does not require heterodimerization with BAX. Bcl-XL Protein, Mouse (His, solution) is the recombinant mouse-derived Bcl-XL protein, expressed by E. coli , with C-His labeled tag.

HY-P72846A

	Bcl-XL Protein, Mouse (C-His) Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X; Bclx	Mouse	E. coli
	Bcl-XL protein forms heterodimers with BAX, BAK, or BCL2, but its antiapoptotic activity does not require heterodimerization with BAX. Bcl-XL Protein, Mouse (C-His) is the recombinant mouse-derived Bcl-XL, expressed by E. coli , with C-6*His labeled tag.

HY-P702869

	PGAM5 Protein, Human (His) Bcl-xL-binding protein v68; Phosphoglycerate mutase family member 5	Human	E. coli
	PGAM5 Protein, Human (His) is the recombinant human-derived PGAM5, expressed by E. coli , with C-6*His labeled tag. ,

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Source
Tag
Accession
Gene ID
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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / 在庫あり - + カートに追加お問い合わせ

製品番号	製品名	構造式

HY-B0011S

Docetaxel-d9
Docetaxel-d₉ is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule?depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of?bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-10087S

Navitoclax-d8 1 Publications Verification
Navitoclax-d₈ is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .

HY-B0011AS

Docetaxel-d5 trihydrate

Docetaxel-d₅ (trihydrate) is the deuterium labeled Docetaxel (Trihydrate). Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule?depolymerization with an IC₅₀ value of 0.2 μM . Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of?bcl-2?and?bcl-xL?gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis .

HY-N0361S

Dihydrocapsaicin-d3

Dihydrocapsaicin-d₃ is the deuterium labeled Dihydrocapsaicin (HY-N0361) . Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-50907S

ABT-737-d8

ABT 737-d₈ is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research .

HY-N2359S

Chelerythrine-d6 chloride

Chelerythrine-d₆ is the deuterium labeled Chelerythrine (HY-N2359). Chelerythrine is a natural alkaloid, acts as a potent and selective Ca ²⁺/phospholopid-dependent PKC antagonist, with an IC₅₀ of 0.7 μM . Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity . Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with an IC₅₀ of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine triggers apoptosis and autophagy .

Host:	Rabbit (7)
Reactivity:	Human (7) Rat (4) Mouse (4)
Application:	IHC-P (4) ICC/IF (4) IP (5) WB (6) FC (3) ELISA (3)
Isotype:	IgG (7)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (7) Recombinant (5)
Modification:	Phosphorylated (1) Unmodified (6)

製品番号	Compare	製品名	Application	Reactivity	Image

HY-P80030

	Bcl-XL Antibody (YA588) 1 Publications Verification	WB, ICC/IF, IHC-P, FC, IP	Human
	Bcl-XL Antibody (YA588) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-XL.

HY-P80030A

	Bcl-XL Antibody (YA588)(PBS only)	WB, ICC/IF, IHC-P, FC, IP	Human
	Bcl-XL Antibody (YA588)(PBS only) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-XL.

HY-P81614

	Bcl-XL Antibody (YA1359) Bcl2L1; Bcl2L; BclX; Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X	FC, ELISA	Human
	Bcl-XL Antibody (YA1359) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-XL.

HY-P86554

	Bcl-XL Antibody (YA6246) Bcl2L1; Bcl2L; BclX; Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Bcl-XL Antibody (YA6246) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-XL.

HY-P86533

	Bad Antibody (YA6225) BAD; BBC6; Bcl2L8; Bcl2 antagonist of cell death; BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-xL/Bcl-2-associated death promoter	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Bad Antibody (YA6225) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bad.

HY-P83354

	Phospho-Bad (Ser112) Antibody (YA3099) BAD; BBC6; Bcl2L8; Bcl2 antagonist of cell death; BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-xL/Bcl-2-associated death promoter	WB, IP	Human, Mouse, Rat
	Phospho-Bad (Ser112) Antibody (YA3099) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Bad (Ser112).

HY-P87008

	PGAM5 Antibody (YA6701) Bcl-xL-binding protein v68 antibody; BxLBv68 antibody; MGC5352 antibody; mitochondrial antibody; PGAM5 antibody; PGAM5_HUMAN antibody; Phosphoglycerate mutase family member 5 antibody; Serine/threonine protein phosphatase PGAM5 mitochondrial antibody; Serine/threonine-protein phosphatase PGAM5 antibody;	WB	Human, Mouse, Rat
	PGAM5 Antibody (YA6701) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PGAM5.

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製品番号	製品名		Classification

HY-178067

Phthalimidinoglutarimide-5-piperazine-COC2-alkynes		Alkynes
Phthalimidinoglutarimide-5-piperazine-COC2-alkynes is a synthesized E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC BCL-xL/BCL-w Degrader 1 (HY-178066). PROTAC BCL-xL/BCL-w Degrader 1 is a potent BCL-xL/BCL-w PROTAC degrader with anti-cancer activity .

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