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Biosynthetic precursor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin-converting Enzyme (ACE) (1) Antibiotic (2) Apoptosis (1) Aryl Hydrocarbon Receptor (1) Bacterial (8) Biochemical Assay Reagents (2) COX (1) Cytochrome P450 (3) Drug Derivative (1) Drug Intermediate (13) Endogenous Metabolite (18) Exosomes (1) Ferroptosis (1) Fungal (3) Herbicide (1) Isotope-Labeled Compounds (4) Lipoxygenase (1) MDM-2/p53 (1) NF-κB (1) p38 MAPK (1) Parasite (2) Reference Standards (7) SARS-CoV (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Endocrinology (1) Infection (16) Inflammation/Immunology (4) Metabolic Disease (12) Neurological Disease (7)

By Targets:

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (2)

Apoptosis (1)

Aryl Hydrocarbon Receptor (1)

Bacterial (8)

Biochemical Assay Reagents (2)

COX (1)

Cytochrome P450 (3)

Drug Derivative (1)

Drug Intermediate (13)

Endogenous Metabolite (18)

Exosomes (1)

Ferroptosis (1)

Fungal (3)

Herbicide (1)

Isotope-Labeled Compounds (4)

Lipoxygenase (1)

MDM-2/p53 (1)

NF-κB (1)

p38 MAPK (1)

Parasite (2)

Reference Standards (7)

SARS-CoV (1)

By Research Areas:

Cancer (4)

Cardiovascular Disease (1)

Endocrinology (1)

Infection (16)

Inflammation/Immunology (4)

Metabolic Disease (12)

Neurological Disease (7)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113279

7-Dehydrocholesterol Maximum Cited Publications 7 Publications Verification	Endogenous Metabolite	Others
7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D₃.

HY-118660

Anhydrotetracycline hydrochloride 2 Publications Verification	Antibiotic Bacterial	Infection
Anhydrotetracycline hydrochloride, a tetracycline biosynthetic precursor, is a potent competitive broad-spectrum tetracycline destructase enzymes inhibitor. Anhydrotetracycline hydrochloride is an effector for tetracycline controlled gene expression systems in eukaryotic cells .

HY-126050

(R)-Pantetheine 2 Publications Verification Pantetheine	Endogenous Metabolite	Metabolic Disease
(R)-Pantetheine is the biosynthetic precursor to CoA. (R)-Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA). (R)-Pantetheine has high toxicity .

HY-119663

Averantin	Fungal	Infection
Averantin is the minor metabolite of the fungus Cercospora arachidicola . Averantin is an aflatoxin B1 precursor that can be used in the biosynthetic pathway .

HY-W090292

Olivetolic acid	Drug Intermediate	Neurological Disease
Olivetolic acid is a biosynthetic precursor of cannabinol acid (CBGA). Olivetolic acid exhibits a modest anticonvulsant effect in a mouse model of Dravet syndrome. Olivetolic acid can be used for the study of convulsion .

HY-N9960

α-Isopropylmalate α-IPM	Drug Intermediate	Others
α-Isopropylmalate (α-IPM) is the leucine biosynthetic precursor in Yeast .

HY-W018758

1-Phenylpropane-1,2-dione	SARS-CoV	Others Metabolic Disease
1-Phenylpropane-1,2-dione, isolated from young Ephedra sinica Stapf (Ephedraceae), is biosynthetic precursors of the ephedrine alkaloids .

HY-W001963

Pyrrole-2-carboxylic acid	Endogenous Metabolite	Others
Pyrrole-2-carboxylic acid is a natural alkaloid from the marine bacterium Pelomonas puraquae sp. Nov. Pyrrole-2-carboxylic acid is a biological form of pyrrole that is often encountered in natural compounds. Pyrrole-2-carboxylic acid serves as a precursor for various pyrrole derivatives like clorobiocin, coumermycin A1, pyoluteorin, leupyrrins, and undecylprodigiosin in biosynthetic processes .

HY-113279S

7-Dehydrocholesterol-d7	Endogenous Metabolite	Others
7-Dehydrocholesterol-d₇ is the deuterium labeled 7-Dehydrocholesterol. 7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3 .

HY-113206

D-Sedoheptulose 7-phosphate	Endogenous Metabolite	Metabolic Disease
D-Sedoheptulose 7-phosphate is a common *precursor* for the heptoses of septacidin (group III) and hygromycin B (group IV). D-Sedoheptulose 7-phosphate can be converted to NDP-heptoses through similar biosynthetic pathways in those compounds .

HY-113206A

D-Sedoheptulose-7-phosphate barium 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
D-Sedoheptulose-7-phosphate barium is a common *precursor* for the heptoses of septacidin (group III) and hygromycin B (group IV). D-Sedoheptulose-7-phosphate barium can be converted to NDP-heptoses through similar biosynthetic pathways in those compounds .

HY-33893

Indole-3-methanamine 2 Publications Verification	Drug Derivative Drug Intermediate	Infection
Indole-3-methanamine is an indole derivative, stress-related metabolite, and also a biosynthetic precursor of Gramine (HY-N0166). The accumulation level of Indole-3-methanamine increases in susceptible barley varieties infected with Bipolaris sorokiniana. Indole-3-methanamine can be used in studies related to barley spot blotch .

HY-W017167

Pyrrolidin-2-yl-acetic acid hydrochloride	Drug Intermediate	Neurological Disease
Pyrrolidin-2-yl-acetic acid hydrochloride is the precursor for the biosynthesis of Tussilagine (HY-N1388) and Isotussilagine. Pyrrolidin-2-yl-acetic acid hydrochloride can be used in neurological research .

HY-N4106

Dihydroartemisinic acid Dihydroqinghao acid	Parasite Ferroptosis	Infection
Dihydroartemisinic acid (Dihydroqinghao acid) is a biosynthetic precursor to the antimalarial agent Artemisinin (HY-B0094) .

HY-W476434

meso-2,6-Diaminopimelic acid	Bacterial	Others
Meso-2,6-Diaminopimelic acid serves as the penultimate biosynthetic precursor for the essential amino acid L-lysine and is an important component of peptidoglycan found in the cell walls of numerous bacterial species.

HY-N1356A

(R)-Reticuline	Cytochrome P450	Inflammation/Immunology
(R)-Reticuline is a key intermediate and precursor in the biosynthetic pathway of morphinan alkaloids. (R)-Reticuline plays a central role in the metabolism of opium poppy (Papaver somniferum). (R)-Reticuline can either undergo O-methylation catalyzed by PSOMT1, or be converted to (+)-Salutaridine via regioselective and stereoselective oxidative coupling under the action of salutaridine synthase (CYP719B1). (R)-Reticuline serves as a direct precursor for the synthesis of important alkaloids such as morphine, codeine and thebaine .

HY-W077634

3-Amino-5-hydroxybenzoic acid AHBA	Drug Intermediate	Infection
3-Amino-5-hydroxybenzoic acid is a biosynthetic precursor of the mC7N unit of ansamycin antibiotics, including ansatrienin A and geldanamycin, as well as the antitumor antibiotic mitomycin C. 3-Amino-5-hydroxybenzoic acid may be an early intermediate in the shikimic acid pathway from glucose .

HY-113279R

7-Dehydrocholesterol (Standard)	Endogenous Metabolite Reference Standards	Others
7-Dehydrocholesterol (Standard) is the analytical standard of 7-Dehydrocholesterol. This product is intended for research and analytical applications.7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3.

HY-16304

Mannose 1-phosphate	Endogenous Metabolite	Metabolic Disease
Mannose 1-phosphate is a phosphorylated mannose that serves as a precursor of GDP-mannose, a constituent unit of glycosylation biosynthetic pathways. Mannose 1-phosphate increases intracellular GDP-mannose concentration, promotes normalization of lipid-linked oligosaccharide structures, and enhances the formation of mature N-glycans on cellular proteins. Mannose 1-phosphate can be used in studies related to glycosylation disorders .

HY-128425A

N-Carbamoyl-L-aspartic acid 1 Publications Verification L-Ureidosuccinic acid	Fungal	Infection
N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura ⁺ strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura ^- strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of Saccharomyces cerevisiae by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase .

HY-60252

(±)-Homoproline 2-Pyrrolidineacetic acid	Others	Neurological Disease
(±)-Homoproline (2-Pyrrolidineacetic acid) is the precursor for the biosynthesis of Tussilagine (HY-N1388) and Isotussilagine. (±)-Homoproline can be used in neurological research .

HY-151631

MRV03-070	Bacterial	Infection
MRV03-070 is an inhibitor of colibactin-activating peptidase ClbP with an IC₅₀ value of 69 nM, acts like biosynthetic precursor precolibactin .

HY-N9551

Eriodictyol chalcone	Cytochrome P450 Parasite COX Lipoxygenase	Infection Neurological Disease Cancer
Eriodictyol chalcone is an antioxidant that inhibits multiple key enzymes including 5-LOX (IC₅₀=0.043 μM), aromatase/CYP19A1 (IC₅₀=2.8 μM), PTPase 1B (IC₅₀=1.26 μM), and COX (IC₅₀=34 μM). Eriodictyol chalcone exhibits excellent free radical scavenging activity. Eriodictyol chalcone not only inhibits the growth of plasmodia and enhances the efficacy of Artemisinin (HY-B0094), but also reduces depression-like behaviors in animal models. Eriodictyol chalcone serves as a biosynthetic precursor for Aureusidin (HY-N9834). Eriodictyol chalcone is a potential dietary supplement and herbicide, and it can be applied to research on malaria, depression, breast cancer and other related diseases .

HY-N5110

Marmesinin (-)-Marmesinin; Ammijin	Others	Neurological Disease
Marmesinin ((-)-Marmesinin), a natural coumarin, is a biosynthetic precursor of psoralen and linear furanocoumarins. Marmesinin exhibits significant neuroprotective activities against glutamate-induced toxicity .

HY-151626

MRV03-037	Bacterial	Infection
MRV03-037 is a selective colibactin-activated peptidase (ClbP) inhibitor that blocks the genotoxic effect of Colibactin (HY-145930) on eukaryotic cells. MRV03-037 prevents gut bacterial genotoxin production .

HY-W587751

Arteannuic alcohol Amorpha-4,11-diene-12-ol	Drug Intermediate	Infection
Arteannuic alcohol (Amorpha-4,11-diene-12-ol) is a precursor substance in the biosynthetic pathway of Artemisinin (HY-B0094). Alcohol dehydrogenase catalyzes the dehydrogenation reaction of chlorogenic alcohol to produce artemisinic aldehyde .

HY-129247

Versicolorin A	MDM-2/p53 Aryl Hydrocarbon Receptor Cytochrome P450	Cancer
Versicolorin A is a biosynthetic precursor of Aflatoxin B1 (HY-N6615). Versicolorin A induces phosphorylation of p53. Versicolorin A activates the aryl hydrocarbon receptor AhR and significantly induces the expression of CYP1A1. Versicolorin A exerts genotoxic and cytotoxic effects. Versicolorin A enhances the genotoxicity of aflatoxin B1 in cells by promoting CYP450-mediated bioactivation of aflatoxin B1. Versicolorin A can be used in research related to colorectal cancer and hepatocellular carcinoma .

HY-W717654

1-Deoxy-D-xylulose 5-phosphate	Endogenous Metabolite	Metabolic Disease
1-Deoxy-D-xylulose 5-phosphate (DXP) is a biosynthetic precursor to isoprenoids, thiamin (vitamin B1), and pyridoxol (vitamin B6). 1-Deoxy-D-xylulose 5-phosphate can be utilized in metabolic research .

HY-W715783

Divarinic acid Divaric acid; Divarinolic acid; Varinolic acid	Biochemical Assay Reagents	Others
Divarinic acid (also known as Divaric acid, Divarinolic acid, or Varinolic acid) serves as an intermediate in the biosynthetic pathway of phytocannabinoids, and can be used to synthesize the cannabinoid precursor CBGVA .

HY-W018758R

1-Phenylpropane-1,2-dione (Standard)	Reference Standards Others	Others Metabolic Disease
1-Phenylpropane-1,2-dione, isolated from young Ephedra sinica Stapf (Ephedraceae), is biosynthetic precursors of the ephedrine alkaloids .

HY-111661

6,7-Dimethyl-8-ribityllumazine	Drug Intermediate	Others
6,7-Dimethyl-8-ribityllumazine is a direct biosynthetic precursor of Riboflavin (RBF; HY-B0456). 6,7-Dimethyl-8-ribityllumazine is a noncovalently bound fluorophore of Lumazine protein (LumP), which is a fluorescent accessory protein .

HY-121858

Nicotianamine	Angiotensin-converting Enzyme (ACE)	Metabolic Disease
Nicotianamine can be isolated from the leaves of Nicotiana Tabacum L.. Nicotianamine is a key biosynthetic precursor of phytosiderophores. Nicotianamine is an iron chelating agent and can promote the transport of iron. Nicotianamine is an angiotensin-converting enzyme (ACE) inhibitor with IC₅₀ values of 76 nM and 59 nM for rhACE2 and rhACE, respectively. Nicotianamine is vital in metal nutrition and metal homeostasis of flowering plants .

HY-113225B

Guanosine triphosphate tritris GTP tritris	Endogenous Metabolite Exosomes	Cancer
Guanosine triphosphate tritris (GTP tritris) serves as a vital enhancer of myogenic cell differentiation and plays a critical role in modulating miRNA-myogenic regulator factors. It also facilitates the release of exosomes enriched with guanosine and guanosine-derived molecules, and is regarded as an activated precursor for RNA synthesis. In mitochondrial function, GTP participates in the import of proteins into the matrix, which is essential for various regulated pathways, and is involved in initiating peptide synthesis through the binding of formylmethionyl-tRNA to the ribosome, as well as polypeptide chain elongation. Additionally, GTP acts as a phosphate and pyrophosphate carrier that channels chemical energy into specific biosynthetic pathways. It activates signal transducing G proteins that regulate cellular processes such as proliferation and differentiation, and its hydrolysis by small GTPases, including Ras and Rho, is integral to both proliferation and apoptosis. Furthermore, the small GTPase Rab is instrumental in vesicle docking, fusion, and formation. Beyond signal transduction, GTP is an energy-rich precursor in the enzymatic biosynthesis of DNA and RNA.

HY-N8400

Roridin L2	Endogenous Metabolite	Others
Roridin L2, a fungal metabolite, is a biosynthetic precursor of Satratoxin G. Roridin L2 possesses little in vitro or in vivo toxic activity .

HY-N15013

7-Deoxyloganin	Biochemical Assay Reagents	Others
7-Deoxyloganin serves as a biosynthetic precursor of Loganin (HY-N0512). 7-Deoxyloganin undergoes hydroxylation catalyzed by 7-deoxyloganin 7-hydroxylase, a cytochrome P450-dependent monooxygenase, to produce Loganin .

HY-126574

Pantothenoylcysteine	Endogenous Metabolite	Others
Pantothenoylcysteine is the biosynthetic precursor of CoA. Pantothenoylcysteine can be used to study microbial metabolism .

HY-125538

Deoxybrevianamide E	Endogenous Metabolite	Inflammation/Immunology
Deoxybrevianamide E, an indole alkaloid, is a biosynthetic precursor for advanced metabolites isolated from the marine-derived Aspergillus sp. .

HY-N2139

Protopseudohypericin	Others	Others
Protopseudohypericin, a naturally occurring naphthodianthrone, is isolated from H. perforatum. Protopseudohypericin is considered to be the biosynthetic precursor of Pseudohypericin .

HY-126050S

(R)-Pantetheine-15N Pantetheine-¹⁵N	Isotope-Labeled Compounds	Others
(R)-Pantetheine- ¹⁵N (Pantetheine- ¹⁵N) is the ¹⁵N labeled (R)-Pantetheine (HY-126050). (R)-Pantetheine is the biosynthetic precursor to CoA .

HY-W722128

Olivetolic acid-d9	Isotope-Labeled Compounds Drug Intermediate	Neurological Disease
Olivetolic acid-d₉ is the deuterium labeled Olivetolic acid (HY-W090292). Olivetolic acid is a biosynthetic precursor of cannabinol acid (CBGA). Olivetolic acid has anticonvulsant activity .

HY-126634

Lyngbyatoxin B	Others	Infection
Lyngbyatoxin B is a complex compound in a versatile biosynthetic pathway from the marine cyanobacterium Moorea producens. By heterologously expressing the lyngbyatoxin biosynthetic pathway in Escherichia coli, lyngbyatoxin A (25.6 mg/L) and its precursor indolactam-V (150 mg/L) were successfully produced. This approach confirmed the biosynthetic route of lyngbyatoxin and laid a chemical foundation for future pathway engineering. In addition, the successful production of lyngbyatoxin A in E. coli opens the possibility for heterologous expression and characterization of other cyanobacterial natural products.

HY-N9960R

α-Isopropylmalate (Standard) α-IPM (Standard)	Reference Standards Others	Others
α-Isopropylmalate (Standard) is the analytical standard of α-Isopropylmalate. This product is intended for research and analytical applications. α-Isopropylmalate (α-IPM) is the leucine biosynthetic precursor in Yeast .

HY-118660R

Anhydrotetracycline hydrochloride (Standard)	Reference Standards Antibiotic Bacterial	Infection
Anhydrotetracycline (hydrochloride) (Standard) is the analytical standard of Anhydrotetracycline (hydrochloride). This product is intended for research and analytical applications. Anhydrotetracycline hydrochloride, a tetracycline biosynthetic precursor, is a potent competitive broad-spectrum tetracycline destructase enzymes inhibitor. Anhydrotetracycline hydrochloride is an effector for tetracycline controlled gene expression systems in eukaryotic cells .

HY-N15014

Deoxyradicinin	Bacterial	Others
Deoxyradicinin is a biosynthetic precursor of Radicinin (HY-113816). Deoxyradicinin exhibits inhibitory activity against Xylella fastidiosa and Liberibacter crescens. With a MIC value of 3.5 μg/mL against Liberibacter crescens, Deoxyradicinin shows potential for research into controlling plant diseases caused by these pathogens .

HY-126050R

(R)-Pantetheine (Standard) Pantetheine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
(R)-Pantetheine (Standard) is the analytical standard of (R)-Pantetheine. This product is intended for research and analytical applications. (R)-Pantetheine is the biosynthetic precursor to CoA. (R)-Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA). (R)-Pantetheine has high toxicity .

HY-W719281

(R)-Pantetheine-d4 Pantetheine-d₄	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
(R)-Pantetheine-d₄ (Pantetheine-d₄) is the deuterium labeled (R)-Pantetheine (HY-126050). (R)-Pantetheine is the biosynthetic precursor to CoA. (R)-Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA). (R)-Pantetheine has high toxicity .

HY-16304A

Mannose 1-phosphate sodium	Endogenous Metabolite	Metabolic Disease
Mannose 1-phosphate sodium is a phosphorylated mannose that serves as a precursor of GDP-mannose, a constituent unit of glycosylation biosynthetic pathways. Mannose 1-phosphate sodium increases intracellular GDP-mannose concentration, promotes normalization of lipid-linked oligosaccharide structures, and enhances the formation of mature N-glycans on cellular proteins. Mannose 1-phosphate sodium can be used in studies related to glycosylation disorders .

HY-N7241

Saudin	Others	Endocrinology
Saudin, derived from Clutia lanceolata, is a hypoglycemic compound that significantly enhances glucose-triggered insulin release from murine pancreatic islets. It belongs to a group of new diterpenoids with a distinct tetracyclic core, suggesting potential as a therapeutic agent for diabetes treatment. Proposed biosynthetic pathways outline alternative cyclization routes from a common precursor, with Lanceolide P (16) identified as a promising lead compound for further development in managing diabetes .

HY-W016628R

L-Gulono-1,4-lactone (Standard) L-Gulonolactone (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
L-Gulono-1,4-lactone (L-Gulonolactone) (Standard) is the analytical standard of L-Gulono-1,4-lactone. This product is intended for research and analytical applications. L-Gulono-1,4-lactone is a biosynthetic precursor of L-Ascorbic acid (Vitamin C) (HY-B0166). L-Gulono-1,4-lactone can be enzymatically converted to L-Ascorbic acid via the animal uronic acid pathway, while species such as humans lack the key oxidase that catalyzes this step, resulting in the disruption of this pathway and the necessity to obtain Vitamin C from diet. L-Gulono-1,4-lactone is a putative intermediate in an alternative biosynthetic pathway of L-Ascorbic acid in Arabidopsis thaliana.

HY-W001963R

Pyrrole-2-carboxylic acid (Standard)	Reference Standards Bacterial Drug Intermediate	Infection
Pyrrole-2-carboxylic acid (Standard) is the analytical standard of Pyrrole-2-carboxylic acid (HY-W001963). This product is intended for research and analytical applications. sp. Nov. Pyrrole-2-carboxylic acid shows antibacterial activity and inhibits biofilm formation. Pyrrole-2-carboxylic acid serves as a precursor for various pyrrole derivatives like Clorobiocin (HY-123515), Coumermycin A1 (HY-N7452) in biosynthetic processes .

Cat. No.	Product Name

HY-L064

Glutamine Metabolism Compound Library

1,690 compounds

Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH.

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment.

MCE owns a unique collection of 1,690 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113279

7-Dehydrocholesterol Maximum Cited Publications 7 Publications Verification	Human Gut Microbiota Metabolites Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D₃.

HY-126050

(R)-Pantetheine 2 Publications Verification Pantetheine	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
(R)-Pantetheine is the biosynthetic precursor to CoA. (R)-Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA). (R)-Pantetheine has high toxicity .

HY-119663

Averantin	Infection Quinones Microorganisms Classification of Application Fields Anthraquinones Disease Research Fields Source Classification	Fungal
Averantin is the minor metabolite of the fungus Cercospora arachidicola . Averantin is an aflatoxin B1 precursor that can be used in the biosynthetic pathway .

HY-N9960

α-Isopropylmalate α-IPM	Microorganisms Animals Ketones, Aldehydes, Acids Source Classification	Drug Intermediate
α-Isopropylmalate (α-IPM) is the leucine biosynthetic precursor in Yeast .

HY-W018758

1-Phenylpropane-1,2-dione	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Ephedraceae Other Diseases Plants Disease Research Fields Ephedra sinica Stapf Source Classification	SARS-CoV
1-Phenylpropane-1,2-dione, isolated from young Ephedra sinica Stapf (Ephedraceae), is biosynthetic precursors of the ephedrine alkaloids .

HY-W001963

Pyrrole-2-carboxylic acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Marine natural products Other Diseases Endogenous metabolite Marine microorganism Disease Research Fields Source Classification	Endogenous Metabolite
Pyrrole-2-carboxylic acid is a natural alkaloid from the marine bacterium Pelomonas puraquae sp. Nov. Pyrrole-2-carboxylic acid is a biological form of pyrrole that is often encountered in natural compounds. Pyrrole-2-carboxylic acid serves as a precursor for various pyrrole derivatives like clorobiocin, coumermycin A1, pyoluteorin, leupyrrins, and undecylprodigiosin in biosynthetic processes .

HY-113206

D-Sedoheptulose 7-phosphate	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
D-Sedoheptulose 7-phosphate is a common *precursor* for the heptoses of septacidin (group III) and hygromycin B (group IV). D-Sedoheptulose 7-phosphate can be converted to NDP-heptoses through similar biosynthetic pathways in those compounds .

HY-33893

Indole-3-methanamine 2 Publications Verification	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Drug Derivative Drug Intermediate
Indole-3-methanamine is an indole derivative, stress-related metabolite, and also a biosynthetic precursor of Gramine (HY-N0166). The accumulation level of Indole-3-methanamine increases in susceptible barley varieties infected with Bipolaris sorokiniana. Indole-3-methanamine can be used in studies related to barley spot blotch .

HY-W017167

Pyrrolidin-2-yl-acetic acid hydrochloride	Structural Classification Alkaloids Pyrrole Alkaloids Melampodium divaricatum (Rich.) DC. Plants Compositae Source Classification	Drug Intermediate
Pyrrolidin-2-yl-acetic acid hydrochloride is the precursor for the biosynthesis of Tussilagine (HY-N1388) and Isotussilagine. Pyrrolidin-2-yl-acetic acid hydrochloride can be used in neurological research .

HY-N4106

Dihydroartemisinic acid Dihydroqinghao acid	Infection other families Classification of Application Fields Terpenoids Sesquiterpenes Plants Disease Research Fields Source Classification	Parasite Ferroptosis
Dihydroartemisinic acid (Dihydroqinghao acid) is a biosynthetic precursor to the antimalarial agent Artemisinin (HY-B0094) .

HY-N1356A

(R)-Reticuline	Structural Classification Alkaloids Plants Lauraceae Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm. Source Classification	Cytochrome P450
(R)-Reticuline is a key intermediate and precursor in the biosynthetic pathway of morphinan alkaloids. (R)-Reticuline plays a central role in the metabolism of opium poppy (Papaver somniferum). (R)-Reticuline can either undergo O-methylation catalyzed by PSOMT1, or be converted to (+)-Salutaridine via regioselective and stereoselective oxidative coupling under the action of salutaridine synthase (CYP719B1). (R)-Reticuline serves as a direct precursor for the synthesis of important alkaloids such as morphine, codeine and thebaine .

HY-113279R

7-Dehydrocholesterol (Standard)	Microorganisms Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite Reference Standards
7-Dehydrocholesterol (Standard) is the analytical standard of 7-Dehydrocholesterol. This product is intended for research and analytical applications.7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3.

HY-16304

Mannose 1-phosphate	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Mannose 1-phosphate is a phosphorylated mannose that serves as a precursor of GDP-mannose, a constituent unit of glycosylation biosynthetic pathways. Mannose 1-phosphate increases intracellular GDP-mannose concentration, promotes normalization of lipid-linked oligosaccharide structures, and enhances the formation of mature N-glycans on cellular proteins. Mannose 1-phosphate can be used in studies related to glycosylation disorders .

HY-128425A

N-Carbamoyl-L-aspartic acid 1 Publications Verification L-Ureidosuccinic acid	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Fungal
N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura ⁺ strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura ^- strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of Saccharomyces cerevisiae by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase .

HY-60252

(±)-Homoproline 2-Pyrrolidineacetic acid	Structural Classification Alkaloids Pyrrole Alkaloids Melampodium divaricatum (Rich.) DC. Plants Compositae Source Classification	Others
(±)-Homoproline (2-Pyrrolidineacetic acid) is the precursor for the biosynthesis of Tussilagine (HY-N1388) and Isotussilagine. (±)-Homoproline can be used in neurological research .

HY-N9551

Eriodictyol chalcone	Structural Classification Chalcones Flavonoids Classification of Application Fields Phenols Polyphenols Metabolic Disease Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Umbelliferae Plants Disease Research Fields Source Classification	Cytochrome P450 Parasite COX Lipoxygenase
Eriodictyol chalcone is an antioxidant that inhibits multiple key enzymes including 5-LOX (IC₅₀=0.043 μM), aromatase/CYP19A1 (IC₅₀=2.8 μM), PTPase 1B (IC₅₀=1.26 μM), and COX (IC₅₀=34 μM). Eriodictyol chalcone exhibits excellent free radical scavenging activity. Eriodictyol chalcone not only inhibits the growth of plasmodia and enhances the efficacy of Artemisinin (HY-B0094), but also reduces depression-like behaviors in animal models. Eriodictyol chalcone serves as a biosynthetic precursor for Aureusidin (HY-N9834). Eriodictyol chalcone is a potential dietary supplement and herbicide, and it can be applied to research on malaria, depression, breast cancer and other related diseases .

HY-N5110

Marmesinin (-)-Marmesinin; Ammijin	Pseudognaphalium affine (D. Don) Anderberg Coumarins Phenylpropanoids Plants Umbelliferae Source Classification	Others
Marmesinin ((-)-Marmesinin), a natural coumarin, is a biosynthetic precursor of psoralen and linear furanocoumarins. Marmesinin exhibits significant neuroprotective activities against glutamate-induced toxicity .

HY-129247

Versicolorin A	Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Other Diseases Disease Research Fields Source Classification	MDM-2/p53 Aryl Hydrocarbon Receptor Cytochrome P450
Versicolorin A is a biosynthetic precursor of Aflatoxin B1 (HY-N6615). Versicolorin A induces phosphorylation of p53. Versicolorin A activates the aryl hydrocarbon receptor AhR and significantly induces the expression of CYP1A1. Versicolorin A exerts genotoxic and cytotoxic effects. Versicolorin A enhances the genotoxicity of aflatoxin B1 in cells by promoting CYP450-mediated bioactivation of aflatoxin B1. Versicolorin A can be used in research related to colorectal cancer and hepatocellular carcinoma .

HY-W018758R

1-Phenylpropane-1,2-dione (Standard)	Structural Classification Ketones, Aldehydes, Acids Ephedraceae Plants Ephedra sinica Stapf Source Classification	Reference Standards Others
1-Phenylpropane-1,2-dione, isolated from young Ephedra sinica Stapf (Ephedraceae), is biosynthetic precursors of the ephedrine alkaloids .

HY-121858

Nicotianamine	Nicotiana tabacum L. Ketones, Aldehydes, Acids Solanaceae Plants Source Classification	Angiotensin-converting Enzyme (ACE)
Nicotianamine can be isolated from the leaves of Nicotiana Tabacum L.. Nicotianamine is a key biosynthetic precursor of phytosiderophores. Nicotianamine is an iron chelating agent and can promote the transport of iron. Nicotianamine is an angiotensin-converting enzyme (ACE) inhibitor with IC₅₀ values of 76 nM and 59 nM for rhACE2 and rhACE, respectively. Nicotianamine is vital in metal nutrition and metal homeostasis of flowering plants .

HY-N8400

Roridin L2	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Disease Research Fields Source Classification	Endogenous Metabolite
Roridin L2, a fungal metabolite, is a biosynthetic precursor of Satratoxin G. Roridin L2 possesses little in vitro or in vivo toxic activity .

HY-N15013

7-Deoxyloganin	Structural Classification Caprifoliaceae Iridoids Lonicera japonica Thunb. Terpenoids Plants Source Classification	Biochemical Assay Reagents
7-Deoxyloganin serves as a biosynthetic precursor of Loganin (HY-N0512). 7-Deoxyloganin undergoes hydroxylation catalyzed by 7-deoxyloganin 7-hydroxylase, a cytochrome P450-dependent monooxygenase, to produce Loganin .

HY-125538

Deoxybrevianamide E	Alkaloids Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Marine natural products Endogenous metabolite Marine microorganism Inflammation/Immunology Disease Research Fields Indole Alkaloids Source Classification	Endogenous Metabolite
Deoxybrevianamide E, an indole alkaloid, is a biosynthetic precursor for advanced metabolites isolated from the marine-derived Aspergillus sp. .

HY-N2139

Protopseudohypericin	Quinones Structural Classification Hypericum perforatum Linn. Classification of Application Fields Anthraquinones Guttiferae Other Diseases Plants Disease Research Fields Source Classification	Others
Protopseudohypericin, a naturally occurring naphthodianthrone, is isolated from H. perforatum. Protopseudohypericin is considered to be the biosynthetic precursor of Pseudohypericin .

HY-126634

Lyngbyatoxin B	Structural Classification Alkaloids other families Plants Lyngbya majuscule Indole Alkaloids Source Classification	Others
Lyngbyatoxin B is a complex compound in a versatile biosynthetic pathway from the marine cyanobacterium Moorea producens. By heterologously expressing the lyngbyatoxin biosynthetic pathway in Escherichia coli, lyngbyatoxin A (25.6 mg/L) and its precursor indolactam-V (150 mg/L) were successfully produced. This approach confirmed the biosynthetic route of lyngbyatoxin and laid a chemical foundation for future pathway engineering. In addition, the successful production of lyngbyatoxin A in E. coli opens the possibility for heterologous expression and characterization of other cyanobacterial natural products.

HY-N9960R

α-Isopropylmalate (Standard) α-IPM (Standard)	Microorganisms Animals Ketones, Aldehydes, Acids Source Classification	Reference Standards Others
α-Isopropylmalate (Standard) is the analytical standard of α-Isopropylmalate. This product is intended for research and analytical applications. α-Isopropylmalate (α-IPM) is the leucine biosynthetic precursor in Yeast .

HY-N15014

Deoxyradicinin	Natural Products Microorganisms Source Classification	Bacterial
Deoxyradicinin is a biosynthetic precursor of Radicinin (HY-113816). Deoxyradicinin exhibits inhibitory activity against Xylella fastidiosa and Liberibacter crescens. With a MIC value of 3.5 μg/mL against Liberibacter crescens, Deoxyradicinin shows potential for research into controlling plant diseases caused by these pathogens .

HY-126050R

(R)-Pantetheine (Standard) Pantetheine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
(R)-Pantetheine (Standard) is the analytical standard of (R)-Pantetheine. This product is intended for research and analytical applications. (R)-Pantetheine is the biosynthetic precursor to CoA. (R)-Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA). (R)-Pantetheine has high toxicity .

HY-N7241

Saudin	Clutia lanceolata Forssk. Other Monoterpenes Terpenoids Euphorbiaceae Plants Source Classification	Others
Saudin, derived from Clutia lanceolata, is a hypoglycemic compound that significantly enhances glucose-triggered insulin release from murine pancreatic islets. It belongs to a group of new diterpenoids with a distinct tetracyclic core, suggesting potential as a therapeutic agent for diabetes treatment. Proposed biosynthetic pathways outline alternative cyclization routes from a common precursor, with Lanceolide P (16) identified as a promising lead compound for further development in managing diabetes .

HY-W016628R

L-Gulono-1,4-lactone (Standard) L-Gulonolactone (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Saccharides Source Classification	Reference Standards Endogenous Metabolite
L-Gulono-1,4-lactone (L-Gulonolactone) (Standard) is the analytical standard of L-Gulono-1,4-lactone. This product is intended for research and analytical applications. L-Gulono-1,4-lactone is a biosynthetic precursor of L-Ascorbic acid (Vitamin C) (HY-B0166). L-Gulono-1,4-lactone can be enzymatically converted to L-Ascorbic acid via the animal uronic acid pathway, while species such as humans lack the key oxidase that catalyzes this step, resulting in the disruption of this pathway and the necessity to obtain Vitamin C from diet. L-Gulono-1,4-lactone is a putative intermediate in an alternative biosynthetic pathway of L-Ascorbic acid in Arabidopsis thaliana.

HY-W001963R

Pyrrole-2-carboxylic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Marine natural products Endogenous metabolite Marine microorganism Source Classification	Reference Standards Bacterial Drug Intermediate
Pyrrole-2-carboxylic acid (Standard) is the analytical standard of Pyrrole-2-carboxylic acid (HY-W001963). This product is intended for research and analytical applications. sp. Nov. Pyrrole-2-carboxylic acid shows antibacterial activity and inhibits biofilm formation. Pyrrole-2-carboxylic acid serves as a precursor for various pyrrole derivatives like Clorobiocin (HY-123515), Coumermycin A1 (HY-N7452) in biosynthetic processes .

HY-N19310

Stemmadenine	Apocynaceae Structural Classification Alkaloids Tabernaemontana litoralis Kunth Plants Indole Alkaloids Source Classification	Drug Intermediate
Stemmadenine is a strychnos-type monoterpenoid indole alkaloid that serves as a biosynthetic precursor of the monoterpenoid indole alkaloid skeleton .

HY-107296

1-Acetyltrichilinin	Terpenoids Diterpenoids Melia volkensii Gürke Plants Meliaceae Munronia unifoliolata Oliv. Source Classification	Others
1-Acetyltrichilinin is a limonoid that can be isolated from the fruit of Melia toosendan and is a biosynthetic precursor of voltagenin .

HY-N13283

Glyceollidin I	Structural Classification Natural Products Leguminosae Glycine max (L.) merr Lignans Phenylpropanoids Plants Source Classification	Drug Intermediate
Glyceollidin I is an isoflavonoid derivative present in soybean (Glycine max) tissues. Glyceollidin I is produced in soybean tissues in response to biotic or abiotic factors, and serves as a biosynthetic precursor of Glyceollin I (HY-N11785) .

HY-171664

ent-Copalyl diphosphate ent-CPP	Structural Classification Acanthaceae Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Source Classification	Endogenous Metabolite
ent-Copalyl diphosphate (ent-CPP) is a terpenoid precursor and metabolite involved in plant biosynthetic pathways. ent-Copalyl diphosphate participates in metabolism of natural products including phytoalexins in rice and maize, and steviol glycoside in Stevia rebaudiana .

HY-N17022

Methyl pechueloate	Structural Classification Terpenoids Sesquiterpenes Asteraceae Plants Pechuel-loeschea leubnitziae (Kuntze) O.Hoffm. Source Classification	Others
Methyl pechueloate is a guaiane-type sesquiterpene ester compound, a potential precursor of xerantholide, and is used in the structural analysis and biosynthetic pathway research of sesquiterpenoid compounds. Methyl pechueloate can be naturally extracted from the aerial parts of Pechuel-Loeschea leibnitziae (Kuntze) O. Hoffm .

HY-N9715

4-Chloropinselin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Herbicide
4-Chloropinselin is a chlorine-containing xanthone herbicide that can be isolated from Alternaria sonchi. 4-Chloropinselin is a biosynthetic precursor or degradation product of chloromonilicin and exhibits phytotoxic and antimicrobial activity. 4-Chloropinselin can inhibit the growth of weeds such as field sowthistle and suppress the proliferation of certain microorganisms .

HY-N13282

Glyceocarpin	Structural Classification Natural Products Leguminosae Glycine max (L.) merr Phenols Polyphenols Plants Source Classification	Bacterial Fungal
Glyceocarpin is a phytoalexin and antibacterial agent naturally occurring in Glycine max, with weak antifungal activity. Glyceocarpin serves as the biosynthetic precursor of Glyceollins II (HY-N18032) and Glyceollins III. Glyceocarpin can be biosynthesized by the prenyltransferase and subsequent modification by cytochrome P450 enzymes. Glyceocarpin can be used for the study of soybean root and stem rot caused by Phytophthora sojae .

HY-N2423B

(E/Z)-Sinigrin free base (E/Z)-Allyl-glucosinolate free base; (E/Z)-2-Propenyl-glucosinolate free base	Structural Classification Glucosinolates Plants Brassicaceae Source Classification Mutarda nigra (L.) Bernh.	NF-κB p38 MAPK Apoptosis
(E/Z)-Sinigrin ((E/Z)-Allyl-glucosinolate; (E/Z)-2-Propenyl-glucosinolate) free base is an orally active aliphatic thioglucoside anti-leukemia compound. Allyl isothiocyanate, produced by the hydrolysis of (E/Z)-sinigrin free base by myrosinase, has an IC₅₀ of 2.71 μM against HL60 leukemia cells. The hydrolysis products of (E/Z)-sinigrin free base can further activate apoptosis pathways, inhibit NF-κB and MAPK signaling pathways, and induce phase II metabolic enzyme activity, thus exhibiting anti-cancer, anti-inflammatory, antibacterial, antioxidant, and wound healing activities. (E/Z)-Sinigrin free base can be used in research on cancer, inflammation-related diseases (such as atherosclerosis), and infectious diseases. (E/Z)-Sinigrin free base can be naturally extracted from the seeds of Brassica nigra, Brassica juncea, and other Brassicaceae plants such as broccoli and Brussels sprouts. Methyl pechueloate is a guaiane-type sesquiterpene ester compound and a potential precursor of xerantholide. It is useful in the structural elucidation and biosynthetic pathway studies of sesquiterpenoids. Methyl pechueloate can be naturally extracted from the aerial parts of Pechuel-Loeschea leibnitziae (Kuntze) O. Hoffm .

Cat. No.	Product Name	Chemical Structure

HY-113279S

7-Dehydrocholesterol-d7
7-Dehydrocholesterol-d₇ is the deuterium labeled 7-Dehydrocholesterol. 7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3 .

HY-126050S

(R)-Pantetheine-15N
(R)-Pantetheine- ¹⁵N (Pantetheine- ¹⁵N) is the ¹⁵N labeled (R)-Pantetheine (HY-126050). (R)-Pantetheine is the biosynthetic precursor to CoA .

HY-W722128

Olivetolic acid-d9
Olivetolic acid-d₉ is the deuterium labeled Olivetolic acid (HY-W090292). Olivetolic acid is a biosynthetic precursor of cannabinol acid (CBGA). Olivetolic acid has anticonvulsant activity .

HY-W719281

(R)-Pantetheine-d4
(R)-Pantetheine-d₄ (Pantetheine-d₄) is the deuterium labeled (R)-Pantetheine (HY-126050). (R)-Pantetheine is the biosynthetic precursor to CoA. (R)-Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA). (R)-Pantetheine has high toxicity .

HY-178299S

3-Amino-5-hydroxybenzoic acid-13C

3-Amino-5-hydroxybenzoic acid- ¹³C is the ¹³C-labeled 3-Amino-5-hydroxybenzoic acid (HY-W077634). 3-Amino-5-hydroxybenzoic acid is a biosynthetic precursor of the mC7N unit of ansamycin antibiotics, including ansatrienin A and geldanamycin, as well as the antitumor antibiotic mitomycin C. 3-Amino-5-hydroxybenzoic acid may be an early intermediate in the shikimic acid pathway from glucose .

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