(R)-Pantetheine (Synonyms: Pantetheine)

Cat. No.: HY-126050 Purity: 99.72%: FAQs
Data Sheet SDS COA Handling Instructions

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(R)-Pantetheine is the biosynthetic precursor to CoA. (R)-Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA).

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(R)-Pantetheine Chemical Structure

CAS No. : 496-65-1

Size	Price	Stock	Quantity
Solid or liquid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 66	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 66	In-stock	Estimated Time of Arrival: December 31
Solid or liquid
5 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 340	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-Pantetheine:

(R)-Pantetheine-¹⁵N Get quote

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Biological Activity
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Description

(R)-Pantetheine is the biosynthetic precursor to CoA. (R)-Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA)^[1].

IC₅₀ & Target

Human Endogenous Metabolite

Molecular Weight

278.37

Formula

C₁₁H₂₂N₂O₄S

CAS No.

496-65-1

Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C([C@@H](C(C)(CO)C)O)NCCC(NCCS)=O

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (359.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 62.5 mg/mL (224.52 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5923 mL	17.9617 mL	35.9234 mL
5 mM	0.7185 mL	3.5923 mL	7.1847 mL
10 mM	0.3592 mL	1.7962 mL	3.5923 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.98 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.98 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.98 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.72%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (243 KB) HNMR (391 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Rothmann M, et al. Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A. J Am Chem Soc. 2013 Apr 24;135(16):5962-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.5923 mL	17.9617 mL	35.9234 mL	89.8085 mL
	5 mM	0.7185 mL	3.5923 mL	7.1847 mL	17.9617 mL
	10 mM	0.3592 mL	1.7962 mL	3.5923 mL	8.9809 mL
	15 mM	0.2395 mL	1.1974 mL	2.3949 mL	5.9872 mL
	20 mM	0.1796 mL	0.8981 mL	1.7962 mL	4.4904 mL
	25 mM	0.1437 mL	0.7185 mL	1.4369 mL	3.5923 mL
	30 mM	0.1197 mL	0.5987 mL	1.1974 mL	2.9936 mL
	40 mM	0.0898 mL	0.4490 mL	0.8981 mL	2.2452 mL
	50 mM	0.0718 mL	0.3592 mL	0.7185 mL	1.7962 mL
	60 mM	0.0599 mL	0.2994 mL	0.5987 mL	1.4968 mL
	80 mM	0.0449 mL	0.2245 mL	0.4490 mL	1.1226 mL
	100 mM	0.0359 mL	0.1796 mL	0.3592 mL	0.8981 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

(R)-Pantetheine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Pantetheine496-65-1PantetheineEndogenous MetaboliteInhibitorinhibitorinhibit

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(R)-Pantetheine (Synonyms: Pantetheine)

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Other Forms of (R)-Pantetheine:

(R)-Pantetheine Related Antibodies

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Biological Activity

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References

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Complete Stock Solution Preparation Table

(R)-Pantetheine Related Classifications

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