103192-46-7
Chemical Structure
Guanosine triphosphate tritris solution (100 mM)
Synonym(s): GTP tritris solution (100 mM)
- CAS No.: 103192-46-7
- Formula:C22H49N8O23P3
- Molecular Weight:886.59
IUPAC Name: tris(2-amino-2-(hydroxymethyl)propane-1,3-diol) ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate
InChIKey: UXNOYHQEVMMTDK-CYCLDIHTSA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O.OCC(CO)(N)CO.OCC(CO)(N)CO.OCC(CO)(N)CO
Biological Activity:
Guanosine triphosphate (GTP) tritris solution (100 mM) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate tritris solution (100 mM) promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate tritris solution (100 mM) links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate tritris solution (100 mM) accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate tritris solution (100 mM) is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism[1][2][3].
The product specifications provided below indicate the total amount only; they do not represent the actual content of Guanosine triphosphate tritris.
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Guanosine triphosphate tritris solution (100 mM) | 99.40% | Guanosine triphosphate (GTP) tritris solution (100 mM) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate tritris solution (100 mM) promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate tritris solution (100 mM) links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate tritris solution (100 mM) accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate tritris solution (100 mM) is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism. The product specifications provided below indicate the total amount only; they do not represent the actual content of Guanosine triphosphate tritris. |
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References
- [1]. Huang F, et al. Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer. J Clin Invest. 2021;131(1):e139929. [Content Brief]
- [2]. Li G, et al. Prolonged depletion of guanosine triphosphate induces death of insulin-secreting cells by apoptosis. Endocrinology. 1998;139(9):3752-3762. [Content Brief]
- [3]. Bolin C, et al. Assessing biomarkers of oxidative stress: analysis of guanosine and oxidized guanosine nucleotide triphosphates by high performance liquid chromatography with electrochemical detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;856(1-2):121-130. [Content Brief]
